Imperial College London
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ProfessorJamesScott

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiovascular Medicine
 
 
 
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j.scott

 
 
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Location

 

Rm. 529ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Teslovich:2010:10.1038/nature09270,
author = {Teslovich, TM and Musunuru, K and Smith, AV and Edmondson, AC and Stylianou, IM and Koseki, M and Pirruccello, JP and Ripatti, S and Chasman, DI and Willer, CJ and Johansen, CT and Fouchier, SW and Isaacs, A and Peloso, GM and Barbalic, M and Ricketts, SL and Bis, JC and Aulchenko, YS and Thorleifsson, G and Feitosa, MF and Chambers, J and Orho-Melander, M and Melander, O and Johnson, T and Li, X and Guo, X and Li, M and Cho, YS and Go, MJ and Kim, YJ and Lee, J-Y and Park, T and Kim, K and Sim, X and Ong, RT-H and Croteau-Chonka, DC and Lange, LA and Smith, JD and Song, K and Zhao, JH and Yuan, X and Luan, J and Lamina, C and Ziegler, A and Zhang, W and Zee, RYL and Wright, AF and Witteman, JCM and Wilson, JF and Willemsen, G and Wichmann, H-E and Whitfield, JB and Waterworth, DM and Wareham, NJ and Waeber, G and Vollenweider, P and Voight, BF and Vitart, V and Uitterlinden, AG and Uda, M and Tuomilehto, J and Thompson, JR and Tanaka, T and Surakka, I and Stringham, HM and Spector, TD},
doi = {10.1038/nature09270},
journal = {Nature},
pages = {707--713},
title = {Biological, clinical and population relevance of 95 loci for blood lipids},
url = {http://dx.doi.org/10.1038/nature09270},
volume = {466},
year = {2010}
}
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TY  - JOUR
AB  - Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 × 10−8), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes—GALNT2, PPP1R3B and TTC39B—with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
AU  - Teslovich,TM
AU  - Musunuru,K
AU  - Smith,AV
AU  - Edmondson,AC
AU  - Stylianou,IM
AU  - Koseki,M
AU  - Pirruccello,JP
AU  - Ripatti,S
AU  - Chasman,DI
AU  - Willer,CJ
AU  - Johansen,CT
AU  - Fouchier,SW
AU  - Isaacs,A
AU  - Peloso,GM
AU  - Barbalic,M
AU  - Ricketts,SL
AU  - Bis,JC
AU  - Aulchenko,YS
AU  - Thorleifsson,G
AU  - Feitosa,MF
AU  - Chambers,J
AU  - Orho-Melander,M
AU  - Melander,O
AU  - Johnson,T
AU  - Li,X
AU  - Guo,X
AU  - Li,M
AU  - Cho,YS
AU  - Go,MJ
AU  - Kim,YJ
AU  - Lee,J-Y
AU  - Park,T
AU  - Kim,K
AU  - Sim,X
AU  - Ong,RT-H
AU  - Croteau-Chonka,DC
AU  - Lange,LA
AU  - Smith,JD
AU  - Song,K
AU  - Zhao,JH
AU  - Yuan,X
AU  - Luan,J
AU  - Lamina,C
AU  - Ziegler,A
AU  - Zhang,W
AU  - Zee,RYL
AU  - Wright,AF
AU  - Witteman,JCM
AU  - Wilson,JF
AU  - Willemsen,G
AU  - Wichmann,H-E
AU  - Whitfield,JB
AU  - Waterworth,DM
AU  - Wareham,NJ
AU  - Waeber,G
AU  - Vollenweider,P
AU  - Voight,BF
AU  - Vitart,V
AU  - Uitterlinden,AG
AU  - Uda,M
AU  - Tuomilehto,J
AU  - Thompson,JR
AU  - Tanaka,T
AU  - Surakka,I
AU  - Stringham,HM
AU  - Spector,TD
AU  - Soranzo,N
AU  - Smit,JH
AU  - Sinisalo,J
AU  - Silander,K
AU  - Sijbrands,EJG
AU  - Scuteri,A
AU  - Scott,J
AU  - Schlessinger,D
AU  - Sanna,S
AU  - Salomaa,V
AU  - Saharinen,J
AU  - Sabatti,C
AU  - Ruokonen,A
AU  - Rudan,I
AU  - Rose,LM
AU  - Roberts,R
AU  - Rieder,M
AU  - Psaty,BM
AU  - Pramstaller,PP
AU  - Pichler,I
AU  - Perola,M
AU  - Penninx,BWJH
AU  - Pedersen,NL
AU  - Pattaro,C
AU  - Parker,AN
AU  - Pare,G
AU  - Oostra,BA
AU  - O'Donnell,CJ
AU  - Nieminen,MS
AU  - Nickerson,DA
AU  - Montgomery,GW
AU  - Meitinger,T
AU  - McPherson,R
AU  - McCarthy,MI
AU  - McArdle,W
AU  - Masson,D
AU  - Martin,NG
AU  - Marroni,F
AU  - Mangino,M
AU  - Magnusson,PKE
AU  - Lucas,G
AU  - Luben,R
AU  - Loos,RJF
AU  - Lokki,M-L
AU  - Lettre,G
AU  - Langenberg,C
AU  - Launer,LJ
AU  - Lakatta,EG
AU  - Laaksonen,R
AU  - Kyvik,KO
AU  - Kronenberg,F
AU  - Koenig,IR
AU  - Khaw,K-T
AU  - Kaprio,J
AU  - Kaplan,LM
AU  - Johansson,A
AU  - Jarvelin,M-R
AU  - Janssens,ACJW
AU  - Ingelsson,E
AU  - Igi,W
AU  - Hovingh,GK
AU  - Hottenga,J-J
AU  - Hofman,A
AU  - Hicks,AA
AU  - Hengstenberg,C
AU  - Heid,IM
AU  - Hayward,C
AU  - Havulinna,AS
AU  - Hastie,ND
AU  - Harris,TB
AU  - Haritunians,T
AU  - Hall,AS
AU  - Gyllensten,U
AU  - Guiducci,C
AU  - Groop,LC
AU  - Gonzalez,E
AU  - Gieger,C
AU  - Freimer,NB
AU  - Ferrucci,L
AU  - Erdmann,J
AU  - Elliott,P
AU  - Ejebe,KG
AU  - Doering,A
AU  - Dominiczak,AF
AU  - Demissie,S
AU  - Deloukas,P
AU  - de,Geus EJC
AU  - de,Faire U
AU  - Crawford,G
AU  - Collins,FS
AU  - Chen,Y-DI
AU  - Caulfield,MJ
AU  - Campbell,H
AU  - Burtt,NP
AU  - Bonnycastle,LL
AU  - Boomsma,DI
AU  - Boekholdt,SM
AU  - Bergman,RN
AU  - Barroso,I
AU  - Bandinelli,S
AU  - Ballantyne,CM
AU  - Assimes,TL
AU  - Quertermous,T
AU  - Altshuler,D
AU  - Seielstad,M
AU  - Wong,TY
AU  - Tai,E
DO  - 10.1038/nature09270
EP  - 713
PY  - 2010///
SN  - 0028-0836
SP  - 707
TI  - Biological, clinical and population relevance of 95 loci for blood lipids
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature09270
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280562500029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://doi.org/10.1038/nature09270
UR  - http://hdl.handle.net/10044/1/86471
VL  - 466
ER  -
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