Imperial College London

ProfessorJohnSeddon

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 5797j.seddon Website

 
 
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Location

 

207EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

201 results found

Zahid IN, Conn CE, Brooks NJ, Seddon JM, Hashim Ret al., 2013, Effects of sugar stereochemistry on lyotropic mesophases of branched-chain synthetic glycolipids, 9th European-Biophysical-Societies-Association Congress, Publisher: SPRINGER, Pages: S132-S132, ISSN: 0175-7571

Conference paper

Seddon JM, 2013, Preface, FARADAY DISCUSSIONS, Vol: 161, Pages: 9-10, ISSN: 1359-6640

Journal article

Kulkarni CV, Ces O, Templer RH, Seddon JMet al., 2013, Pressure effects on a protein-lipid model membrane, SOFT MATTER, Vol: 9, Pages: 6525-6531, ISSN: 1744-683X

Journal article

Tang TYD, Brooks NJ, Jeworrek C, Ces O, Terrill NJ, Winter R, Templer RH, Seddon JMet al., 2012, Hydrostatic Pressure Effects on the Lamellar to Gyroid Cubic Phase Transition of Monolinolein at Limited Hydration, Langmuir

Journal article

Cook AG, Wardell JL, Brooks NJ, Seddon JM, Martínez-Felipe A, Imrie CTet al., 2012, Non-symmetric liquid crystal dimer containing a carbohydrate-based moiety, Carbohydrate Research, Vol: 360, Pages: 78-83

The synthesis and characterisation of a novel non-symmetric liquid crystal dimer, 1-[3-O-(D-glucopyranos-3-yl)]-8-[(4-methoxyazobenzene-40-oxy)]octane is reported. This exhibits glassy behaviour and a highly interdigitated smectic A phase in which the aromatic and alkyl structural fragments overlap. Variable temperature infrared spectroscopy reveals that the strength and extent of hydrogen bonding within the system does not show a marked change at either the glass transition or at the smectic A-isotropic transition. This observation indicates that the smectic A-isotropic transition is driven by changes in the van der Waals interactions between the molecules while hydrogen bonded aggregates persist into the isotropic phase.

Journal article

Sennoga CA, Yeh JSM, Alter J, Stride E, Nihoyannopoulos P, Seddon JM, Haskard DO, Hajnal JV, Tang M-X, Eckersley RJet al., 2012, EVALUATION OF METHODS FOR SIZING AND COUNTING OF ULTRASOUND CONTRAST AGENTS, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 38, Pages: 834-845, ISSN: 0301-5629

Journal article

Charalambous K, Booth PJ, Woscholski R, Seddon JM, Templer RH, Law RV, Barter LMC, Ces Oet al., 2012, Engineering de Novo Membrane-Mediated Protein-Protein Communication Networks, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 134, Pages: 5746-5749, ISSN: 0002-7863

Journal article

Shaw KP, Brooks NJ, Clarke JA, Ces O, Seddon JM, Law RVet al., 2012, Pressure – temperature phase behaviour of natural sphingomyelin extracts, Soft Matter, Vol: 8, Pages: 1070-1078

Sphingomyelin is the only sphingolipid occurring naturally in mammalian cells and can form up to 50% of the total phospholipid content of the myelin sheath which surrounds nerves. Having predominantly long, saturated acyl chains, it has a relatively high chain melting temperature and has been strongly associated with formation of lipid microdomains. Here, the lyotropic phase behaviour of sphingomyelin from three different natural sources (bovine brain, egg yolk and milk) in excess water is studied as a function of temperature and pressure by small- and wide-angle X-ray scattering, and solid state NMR. The different hydrocarbon chain length distributions of the three lipid extracts results in significant differences in their gel phase structure; both the bovine brain and egg yolk sphingomyelins can form a ripple gel phase but milk sphingomyelin forms an interdigitated gel phase due to the high degree of chain mismatch in its longer hydrocarbon chain components.

Journal article

Brooks NJ, Ces O, Templer RH, Seddon JMet al., 2011, Pressure effects on lipid membrane structure and dynamics, CHEMISTRY AND PHYSICS OF LIPIDS, Vol: 164, Pages: 89-98, ISSN: 0009-3084

Journal article

Shearman GC, Brooks NJ, Tiddy GJT, Sztucki M, Templer RH, Law RV, Ces O, Seddon JMet al., 2011, A lyotropic inverse ribbon phase in a branched-chain polyoxyethylene surfactant: pressure effects, SOFT MATTER, Vol: 7, Pages: 4386-4390, ISSN: 1744-683X

Journal article

Tyler AII, Shearman GC, Brooks NJ, Delacroix H, Law RV, Templer RH, Ces O, Seddon JMet al., 2011, Hydrostatic pressure effects on a hydrated lipid inverse micellar Fd3m cubic phase, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 3033-3038, ISSN: 1463-9076

Journal article

Brooks NJ, Hamid HAA, Hashim R, Heidelberg T, Seddon JM, Conn CE, Husseini SMM, Zahid NI, Hussen RSDet al., 2011, Thermotropic and lyotropic liquid crystalline phases of Guerbet branched-chain β-D-glucosides, Liquid Crystals, Vol: 38, Pages: 1725-1734

The effect of chain branching on glycolipid thermotropic and lyotropic phases was investigated for a series ofsynthetic β-D-glucosides derived from Guerbet alcohols, whose total hydrocarbon chain length ranged from C8 toC24. The compounds, which can be viewed as isosteric mimics for glycoglycerolipids, were synthesised in high purityand their liquid crystalline phases were studied using optical polarising microscopy (OPM), and small-angle X-raydiffraction.When dry, the shortest compound (total C8) exhibits a monotropic Lα phase while longer ones (C16 andC20) adopt inverse hexagonal HII phases. The C24 compound forms an ordered lamellar phase at room temperature,but exhibits a metastable HII phase upon cooling. Curiously the intermediate chain length homologue (C12) adoptsan isotropic inverse micellar (L2) phase in the dry state over the range of temperatures studied. Upon hydration,the C8 compound dissolves, and the C12 compound forms a fluid lamellar Lα phase. The C16 Guerbet glucoside (i.e.β-Glc-C10C6) exhibits an inverse bicontinuous cubic phase of space group Ia3d in excess water, never previouslyobserved in branched-chain lipids, and very seldom observed in excess water. The C20 compound remains in theHII phase upon hydrating, with the lattice parameter swelling substantially.

Journal article

Sennoga CA, Mahue V, Loughran J, Casey J, Seddon JM, Tang M, Eckersley RJet al., 2010, ON SIZING AND COUNTING OF MICROBUBBLES USING OPTICAL MICROSCOPY, ULTRASOUND IN MEDICINE AND BIOLOGY, Vol: 36, Pages: 2093-2096, ISSN: 0301-5629

Journal article

Brooks NJ, Gauthe BLLE, Terrill NJ, Rogers SE, Templer RH, Ces O, Seddon JMet al., 2010, Automated high pressure cell for pressure jump x-ray diffraction, REVIEW OF SCIENTIFIC INSTRUMENTS, Vol: 81, ISSN: 0034-6748

Journal article

Sagnella SM, Conn CE, Krodkiewska I, Moghaddam M, Seddon JM, Drummond CJet al., 2010, Ordered Nanostructured Amphiphile Self-Assembly Materials from Endogenous Nonionic Unsaturated Monoethanolamide Lipids in Water, LANGMUIR, Vol: 26, Pages: 3084-3094, ISSN: 0743-7463

Journal article

Mohammad-Aghaie D, Mace E, Sennoga CA, Seddon JM, Bresme Fet al., 2010, Molecular Dynamics Simulations of Liquid Condensed to Liquid Expanded Transitions in DPPC Monolayers, JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 114, Pages: 1325-1335, ISSN: 1520-6106

Journal article

Martin HP, Brooks NJ, Seddon JM, Terrill NJ, Luckham PF, Kowalski AJ, Cabral JTet al., 2010, Complex fluids under microflow probed by SAXS: rapid microfabrication and analysis, 14th International Conference on Small-Angle Scattering (SAS09), Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588

Conference paper

Kulkarni CV, Tang T-Y, Seddon AM, Seddon JM, Ces O, Templer RHet al., 2010, Engineering bicontinuous cubic structures at the nanoscale-the role of chain splay, SOFT MATTER, Vol: 6, Pages: 3191-3194, ISSN: 1744-683X

Journal article

Tyler AII, Shearman GC, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JMet al., 2010, High Pressure Static and Time-Resolved X-Ray Studies of Inverse Phases in Cholesterol / Lipid Mixtures, BIOPHYSICAL JOURNAL, Vol: 98, Pages: 231A-231A, ISSN: 0006-3495

Journal article

Shearman GC, Tyler AII, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JMet al., 2010, Ordered micellar and inverse micellar lyotropic phases, LIQUID CRYSTALS, Vol: 37, Pages: 679-694, ISSN: 0267-8292

Journal article

Baldwin GS, Brooks NJ, Robson RE, Wynveen A, Goldar A, Leikin S, Seddon JM, Kornyshev AAet al., 2009, DNA Double Helices Recognize Mutual Sequence Homology in a Protein Free Environment, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Vol: 26, Pages: 880-880, ISSN: 0739-1102

Journal article

Shearman GC, Ugazio S, Soubiran L, Hubbard J, Ces O, Seddon JM, Templer RHet al., 2009, The lyotropic phase behaviour of ester quaternary surfactants, JOURNAL OF COLLOID AND INTERFACE SCIENCE, Vol: 331, Pages: 463-469, ISSN: 0021-9797

Journal article

Gauthe BLLE, Heron AJ, Seddon JM, Ces O, Templer RHet al., 2009, A high pressure cell for simultaneous osmotic pressure and x-ray diffraction measurements, REVIEW OF SCIENTIFIC INSTRUMENTS, Vol: 80, ISSN: 0034-6748

Journal article

Shearman GC, Ugazio S, Soubiran L, Hubbard J, Ces O, Seddon JM, Templer RHet al., 2009, Factors Controlling the Stability of a Kinetically Hindered Lamellar-Lamellar Transition, JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 113, Pages: 1948-1953, ISSN: 1520-6106

Journal article

Shearman GC, Tyler AII, Brooks NJ, Templer RH, Ces O, Law RV, Seddon JMet al., 2009, A 3-D Hexagonal Inverse Micellar Lyotropic Phase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 131, Pages: 1678-+, ISSN: 0002-7863

Journal article

Squires AM, Conn CE, Seddon JM, Templer RHet al., 2009, Quantitative model for the kinetics of lyotropic phase transitions involving changes in monolayer curvature, SOFT MATTER, Vol: 5, Pages: 4773-4779, ISSN: 1744-683X

Journal article

Clarke JA, Seddon JM, Law RV, 2009, Cholesterol containing model membranes studied by multinuclear solid state NMR spectroscopy, SOFT MATTER, Vol: 5, Pages: 369-378, ISSN: 1744-683X

Journal article

Shearman GC, Yahioglu G, Kirstein J, Milgrom LR, Seddon JMet al., 2009, Synthesis and phase behaviour of beta-octaalkyl porphyrins, JOURNAL OF MATERIALS CHEMISTRY, Vol: 19, Pages: 598-604, ISSN: 0959-9428

Journal article

Yeh JSM, Sennoga C, Mcconnell E, Eckersley R, Tang M, Hill R, Seddon JM, Haskard DO, Nihoyannopoulos Pet al., 2008, Molecular imaging of the heart using contrast ultrasound: acoustic quantification of molecular expressions, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 21-21, ISSN: 0195-668X

Journal article

Yeh JSM, Sennoga C, McConnell E, Eckersley R, Tang M, Dawson D, Boyle JJ, Seddon JM, Stepney A, Haskard DO, Nihoyannopoulos Pet al., 2008, Echo identification and quantification of inflammatory molecules in the heart, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A21-A22, ISSN: 1355-6037

Conference paper

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