Imperial College London

ProfessorJohnSeddon

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 5797j.seddon Website

 
 
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Location

 

207EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tascini:2019:10.1039/c8cp05706k,
author = {Tascini, AS and Noro, MG and Seddon, JM and Chen, R and Bresme, F},
doi = {10.1039/c8cp05706k},
journal = {Physical Chemistry Chemical Physics},
pages = {1471--1477},
title = {Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides},
url = {http://dx.doi.org/10.1039/c8cp05706k},
volume = {21},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The skin surface, our first barrier against the external environment, is covered by the sebum oil, a lipid film composed of sebaceous and epidermal lipids, which is important in the regulation of the hydration level of our skin. Here, we investigate the pathways leading to the transfer of epidermal lipids from the skin lipid bilayer to the sebum. We show that the sebum triglycerides, a major component of sebum, interact strongly with the epidermal lipids and extract them from the bilayer. Using microsecond time scale molecular dynamics simulations, we identify and quantify the free energy associated with the skin lipid extraction process.
AU - Tascini,AS
AU - Noro,MG
AU - Seddon,JM
AU - Chen,R
AU - Bresme,F
DO - 10.1039/c8cp05706k
EP - 1477
PY - 2019///
SN - 1463-9076
SP - 1471
TI - Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides
T2 - Physical Chemistry Chemical Physics
UR - http://dx.doi.org/10.1039/c8cp05706k
UR - https://www.ncbi.nlm.nih.gov/pubmed/30607404
UR - http://hdl.handle.net/10044/1/66704
VL - 21
ER -