Imperial College London


Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemical Physics



+44 (0)20 7594 5797j.seddon Website




207EMolecular Sciences Research HubWhite City Campus






BibTex format

author = {Barriga, HMG and Law, RV and Seddon, JM and Ces, O and Brooks, NJ},
doi = {10.1039/C5CP04239A},
journal = {Physical Chemistry Chemical Physics},
title = {The effect of hydrostatic pressure on model membrane domain composition and lateral compressibility},
url = {},
year = {2015}

RIS format (EndNote, RefMan)

AB - Phase separation in ternary model membranes is known to occur over a range of temperatures and compositions and can be induced by increasing hydrostatic pressure. We have used small angle X-ray scattering (SAXS) to study phase separation along pre-determined tie lines in dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC) and cholesterol (CHOL) mixtures. We can unequivocally distinguish the liquid ordered (Lo) and liquid disordered (Ld) phases in diffraction patterns from biphasic mixtures and compare their lateral compressibility. The variation of tie line endpoints with increasing hydrostatic pressure was determined, at atmospheric pressure and up to 100 MPa. We find an extension and shift of the tie lines towards the DOPC rich region of the phase diagram at increased pressure, this behaviour differs slightly from that reported for decreasing temperature.
AU - Barriga,HMG
AU - Law,RV
AU - Seddon,JM
AU - Ces,O
AU - Brooks,NJ
DO - 10.1039/C5CP04239A
PY - 2015///
SN - 1463-9084
TI - The effect of hydrostatic pressure on model membrane domain composition and lateral compressibility
T2 - Physical Chemistry Chemical Physics
UR -
UR -
ER -