Imperial College London

ProfessorJohnSeddon

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemical Physics
 
 
 
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Contact

 

+44 (0)20 7594 5797j.seddon Website

 
 
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Location

 

207EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kluzek:2017:10.1039/c7sm01620d,
author = {Kluzek, M and Tyler, AII and Wang, S and Chen, R and Marques, CM and Thalmann, F and Seddon, JM and Schmutz, M},
doi = {10.1039/c7sm01620d},
journal = {Soft Matter},
pages = {7571--7577},
title = {Influence of a pH-sensitive polymer on the structure of monoolein cubosomes.},
url = {http://dx.doi.org/10.1039/c7sm01620d},
volume = {13},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers. They provide an appealing road towards the practical use of lipid cubic phases for pharmaceutical and cosmetic applications, and efforts are currently being made to control the encapsulation and release properties of these colloidal objects. We overcome in this work the lack of sensitivity of monoolein cubosomes to pH conditions by using a pH sensitive polymer designed to strongly interact with the lipid structure at low pH. Our cryo-transmission electron microscope (cryo-TEM) and small-angle X-ray scattering (SAXS) results show that in the presence of the polymer the cubic phase structure is preserved at neutral pH, albeit with a larger cell size. At pH 5.5, in the presence of the polymer, the nanostructure of the cubosome particles is significantly altered, providing a pathway to design pH-responsive cubosomes for applications in drug delivery.
AU - Kluzek,M
AU - Tyler,AII
AU - Wang,S
AU - Chen,R
AU - Marques,CM
AU - Thalmann,F
AU - Seddon,JM
AU - Schmutz,M
DO - 10.1039/c7sm01620d
EP - 7577
PY - 2017///
SP - 7571
TI - Influence of a pH-sensitive polymer on the structure of monoolein cubosomes.
T2 - Soft Matter
UR - http://dx.doi.org/10.1039/c7sm01620d
UR - https://www.ncbi.nlm.nih.gov/pubmed/28994440
UR - http://hdl.handle.net/10044/1/54032
VL - 13
ER -