407 results found
Proctor D, Goodall R, Borsky K, et al., 2023, Trends in the mortality, incidence and disability-adjusted life-years of intestinal obstruction and paralytic ileus: observational study of the Global Burden of Disease database, British Journal of Surgery, Vol: 110, Pages: 1650-1654, ISSN: 0007-1323
Ahmad M, Patel K, Davies A, et al., 2023, Non-invasive optical methods to assess tissue perfusion in patients with peripheral arterial disease and diabetes mellitus - a scoping review and discussion, Journal of Vascular Surgery - Vascular Insights
Gwilym B, Pallmann P, Waldron C, et al., 2023, The PERCEIVE (PrEdiction of Risk and Communication of outcomE following major lower limb amputation: a collaboratIVE) study 1-year outcomes, BJS Open, ISSN: 2474-9842
Stoner R, Ahmad M, Patel S, et al., 2023, A comparison between augmented reality and traditional in-person teaching for vascular anastomotic surgical skills training, Journal of Vascular Surgery, ISSN: 0741-5214
Background : Augmented Reality (AR) superimposes computer generated content to a real-world environment through multitudinous devices, and is used across multiple training fora. Its use in vascular surgery education is yet to be formally investigated. The aim is to assess feasibility and effectiveness of remote teaching of vascular anastomosis skills enhanced by AR in the form of the HoloLens2TM Head Mounted Display technology with traditional in-person skills teaching. A remote trainer used video, gestures and images superimposed over participants’ field of vision via the HoloLens2TM to teach the skills. Method: 28 participants underwent a pre-assessment performing an end-to-end vascular anastomosis on an artificial vessel. They were randomly allocated to an AR or in-person group, and underwent two teaching sessions. Individuals were asked to complete a post-session feedback form and assessment (video recorded and anonymised). The videos were marked by two blinded, independent assessors using the Objective Structured Assessment of Technique Skills (OSATS) scoring.Results: There was an overall improvement in both cohorts in OSATS score after the intervention by +7.083 in the in-person group and +8.275 in the AR. Independent T-test was performed and a p-value of 0.422 was obtained - no statistically significant difference in the change in OSATS scores when comparing the skills teaching received in-person with that through AR.Conclusion: Remote teaching enhanced by AR is feasible and effective for the teaching of vascular surgical anastomosis skills, and non-inferior to in-person teaching. There is scope for development of the use of AR in vascular surgical skills training.
Hanbury G, Jani C, Abdallah N, et al., 2023, Geographic and temporal trends in etiology, incidence, and mortality from hepatocellular carcinoma in European Union 15+ countries, Liver Cancer International, ISSN: 2642-3561
Background & Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. This study considers the geographical trends in incidence and mortality from HCC. Methods: Data were obtained for each EU15+ country from the Global Burden of Disease Study database. Age-standardized incidence rates (ASIRs), mortality rates (ASMRs) and disability-adjusted life years (DALYs) were extracted for each year from 1990-2019. Data were subdivided into males and females. Mortality-to-incidence ratios (MIRs) were calculated. All Indices were reported per 100,000 population, and trends were described using Joinpoint regression. Results: ASIRs increased in 17/19 countries in females and 18/19 countries in males between 1990 and 2019. ASMRs increased in all countries except Italy (for both sexes) and Sweden (for females). MIR decreased in all countries except Denmark in males (+8.0) and females (+1.2). Ireland saw the greatest decline in MIR among females (-15.0%) and the United Kingdom for males (-16.4%). DALYs increased in all countries except Italy for males and females and Sweden for females. Conclusions: The incidence of and mortality from hepatocellular carcinoma are increasing in the majority of EU15+ countries. The rise in mortality and fall in MIR may suggest that outcomes from HCC are improving, despite an increased disease burden.
Nabulsi S, Otunla A, Salciccioli J, et al., 2023, HLA matching between donors and recipients improves clinical liver transplant graft survival, Liver International, ISSN: 1478-3223
Hitchman L, Gwilym B, Al-Saadi N, et al., 2023, The Vascular and Endovascular Research Network (VERN): A multidisciplinary collaborative for vascular surgeons in training, Gefasschirurgie, Vol: 28, Pages: 434-437, ISSN: 0948-7034
The Vascular and Endovascular Research Network (VERN) was set up to promote research, to improve the treatment of vascular diseases and to improve the synthesis and dissemination of evidence. The network represents a particular form of collaboration involving trainee doctors and specialists from a wide variety of medical disciplines. It undertakes multicentre projects, which are mostly observational studies and the data collected are analysed and published in a short period of time. This form of research has several advantages including fostering collaboration between different institutes, countries and researchers with different levels of expertise. It also promotes accelerated delivery of evidence and individual professional development. The network has an executive committee that meets every 2 weeks to discuss projects and the entire committee meets every month. An appointed member of the executive committee coordinates the centres participating in projects. Although there has been some scepticism with respect to research collaboratives, raising concerns over the accountability and the contribution of authors, it is paramount that research conducted by a collaborative maintains the same scientific rigour and ethical standards as research conducted by individual academic units.
Turner BRH, Machin M, Salih M, et al., 2023, An Updated Systematic Review and Meta-Analysis of the Impact of Graduated Compression Stockings in Addition to Pharmacological Thromboprophylaxis for Prevention of Venous Thromboembolism in Surgical Inpatients., Ann Surg
OBJECTIVE: This systematic review and meta-analysis compares the rate of venous thromboembolism (VTE) in surgical inpatients with pharmacological thromboprophylaxis and additional graduated compression stockings (GCS) versus pharmacological thromboprophylaxis alone. SUMMARY BACKGROUND DATA: Surgical inpatients have elevated VTE risk; recent studies cast doubt whether GCS confer additional protection against VTE, compared to pharmacological thromboprophylaxis alone. METHODS: The review followed PRISMA guidelines using a registered protocol (CRD42017062655). The MEDLINE and Embase databases were searched to November 2022. Randomised trials reporting VTE rate after surgical procedures, utilising pharmacological thromboprophylaxis, with or without GCS, were included. The rates of deep venous thrombosis (DVT), pulmonary embolism (PE), VTE-related mortality were pooled via fixed and random effects. RESULTS: In head-to-head meta-analysis, the risk of DVT for GCS and pharmacological thromboprophylaxis was 0.85 (95% CI 0.54-1.36) versus for pharmacological thromboprophylaxis alone (2 studies, 70 events, 2653 participants). The risk of DVT in pooled trial arms for GCS and pharmacological thromboprophylaxis was 0.54 (95% CI 0.23-1.25) versus pharmacological thromboprophylaxis alone (33 trial arms, 1228 events, 14,108 participants). The risk of PE for GCS and pharmacological prophylaxis versus pharmacological prophylaxis alone was 0.71 (95% CI 0.0-30.0) (27 trial arms, 32 events, 11,472 participants). There were no between-group differences in VTE-related mortality (27 trial arms, 3 events, 12,982 participants). CONCLUSIONS: Evidence from head-to-head meta-analysis and pooled trial arms demonstrates no additional benefit for GCS in preventing VTE and VTE-related mortality. GCS confer a risk of skin complications and an economic burden; current evidence does not support their use for surgical inpatients.
Burgess L, Babber A, Shalhoub J, et al., 2023, Neuromuscular electrical stimulation for intermittent claudication (NESIC): multicentre, randomised controlled trial, British Journal of Surgery, ISSN: 0007-1323
Jani C, Ahmed A, Singh H, et al., 2023, The burden of acute myeloid leukemia, 1990-2019: estimates from the Global Burden of Disease Study, JCO Global Oncology, ISSN: 2687-8941
Purpose: Acute myeloid leukemia (AML) accounts for 80% of acute leukemia in adults. While progress has been made in treating younger patients in the last two decades, there has been limited improvement for older patients until recently. This study examines the global and EU15+ trends in AML between 1990 and 2019. Methods: We extracted Age-standardized incidence rates (ASIR), age-standardized death rates (ASMR), and DALYs, stratified by sex from the Global Burden of Disease Study database and mortality-to-incidence ratio (MIR) were computed. Trends were compared using Joinpoint regression. Results: The findings show a global increase in AML incidence for both sexes from 1990 to 2019. In the EU15+ countries, most countries exhibited an increase in ASIR for both sexes. Joinpoint revealed that globally for males, ASIR steadily increased until 2010, remained stable until 2015 followed by a decline from till 2019. Similar trends were observed in females. For ASMR, even though there was an increase globally and in most EU15+ countries, there was a statistically significant decrease in mortality rates globally and in the majority of EU15+ countries in recent years. MIR improved in both sexes globally. On age stratification, AML burden was highest among older groups (≥55 years), while the lowest rates were observed in under 20 years old.Conclusion: The findings from our study indicate a global rise in AML incidence and mortality in both sexes and decrease in MIR from 1990 to 2019 suggesting a better survival. However, on Joinpoint analysis there is no change in MIR in women in the last decade and last 4 years in men indicating plateau in survival trends despite recent advances.
Singh H, Jani C, Marshall D, et al., 2023, Cystic fibrosis-related mortality in the United States from 1999 to 2020: an observational analysis of time trends and disparities, Scientific Reports, Vol: 13, ISSN: 2045-2322
Cystic fibrosis transmembrane conductance regulator modulators have revolutionized cystic fibrosis (CF) care in the past decade. This study explores the CF-related mortality trends in the US from 1999 to 2020. We extracted CF-related mortality data from the CDC WONDER database. CF age-standardized mortality rates (ASMRs) were identified by ICD-10 code E84 and were stratified by demographic and geographical variables. Temporal trends were analyzed using Joinpoint modeling. CF-related ASMRs decreased from 1.9 to 1.04 per million population (p = 0.013), with a greater reduction in recent years. This trend was replicated in both sexes. The median age of death increased from 24 to 37 years. CF mortality rates decreased across sex, white race, non-Hispanic ethnicity, census regions, and urbanization status. Incongruent trends were reported in non-white races and Hispanic ethnicity. A lower median age of death was observed in women, non-white races, and Hispanic ethnicity. SARS-CoV-2 infection was the primary cause of death in 1.7% of CF decedents in 2020. The national CF-related mortality rates declined and the median age of death among CF decedents increased significantly indicating better survival in the recent years. The changes were relatively slow during the earlier period of the study, followed by a greater decline lately. We observed patterns of sex, ethnic, racial, and geographical disparities associated with the worsening of the gap between ethnicities, narrowing of the gap between races and rural vs. urban counties, and closing of the gap between sexes over the study period.
Proctor D, Goodall R, Borsky K, et al., 2023, Trends in the mortality, incidence and disability-adjusted life-years of appendicitis in EU15+ countries: an observational study of the Global Burden of Disease database, 1990-2019, International Journal of Surgery, Vol: 109, Pages: 2608-2613, ISSN: 1743-9159
Background: Appendicitis places a substantial burden on healthcare systems, with acute appendicitis alone being the most common abdominal surgical emergency worldwide. Further characterisation of the disease burden in EU15+ countries may help optimise the distribution of healthcare resources. The aim of this observational study was to assess the trends in mortality, incidence and DALYs of appendicitis across European Union (EU) 15+ countries between the years 1990 and 2019, Supplemental Digital Content 3, https://links.lww.com/JS9/A589.Materials and methods: Age standardised mortality rates (ASMRs), age standardised incidence rates (ASIRs) and disability adjusted life years (DALYs) data for appendicitis in males and females were extracted from the 2019 Global Burden of Disease (GBD) study. Temporal trends within the study period were analysed using Joinpoint regression analysis.Results: The median ASMRs across EU15+ countries in 2019 were 0.08/100,000 and 0.13/100,000 for females and males, respectively. Between 1990 and 2019 the median percentage change in ASMR was −52.12% for females and −53.18% in males. The median ASIRs in 2019 for females and males were 251/100,000 and 278/100,000, respectively, with a median percentage change of +7.22% for females and +3.78% for males during the observation period. Decreasing trends in DALYs were observed over the 30-year study period, with median percentage changes of −23.57% and −33.81% for females and males, respectively, Supplemental Digital Content 3, https://links.lww.com/JS9/A589.Conclusion: Overall, a general trend of decreasing appendicitis ASMRs and DALYs was observed across EU15+ countries, despite small overall increases in appendicitis ASIRs, Supplemental Digital Content 3, https://links.lww.com/JS9/A589. Variations in both diagnostic and management strategies over the study period are likely contributory to the changing trends.
Jani CT, Ahmed A, Singh H, et al., 2023, Burden of AML, 1990-2019: Estimates From the Global Burden of Disease Study., JCO Glob Oncol, Vol: 9
PURPOSE: AML accounts for 80% of acute leukemia in adults. While progress has been made in treating younger patients in the past 2 decades, there has been limited improvement for older patients until recently. This study examines the global and European Union (EU) 15+ trends in AML between 1990 and 2019. METHODS: We extracted age-standardized incidence rates (ASIRs), age-standardized death rates (ASMRs), and disability-adjusted life years, stratified by sex from the Global Burden of Disease Study database, and mortality-to-incidence ratio (MIR) were computed. Trends were compared using Joinpoint regression. RESULTS: The findings show a global increase in AML incidence for both sexes from 1990 to 2019. In the EU15+ countries, most countries exhibited an increase in ASIR for both sexes. Joinpoint revealed that globally for male patients, ASIR steadily increased until 2010, remained stable until 2015 followed by a decline till 2019. Similar trends were observed in female patients. For ASMR, although there was an increase globally and in most EU15+ countries, there was a statistically significant decrease in mortality rates globally and in the majority of EU15+ countries in recent years. MIR improved in both sexes globally. On age stratification, AML burden was highest among older groups (55 years and older), while the lowest rates were observed in younger than 20 years. CONCLUSION: The findings from our study indicate a global rise in AML incidence and mortality in both sexes and decrease in MIR from 1990 to 2019 suggesting a better survival. However, on Joinpoint analysis, there is no change in MIR in women in the past decade and past 4 years in men indicating plateau in survival trends despite recent advances.
Sandford B, Garnham A, 2023, The journey to greener vascular surgery, Journal of Vascular Societies Great Britain & Ireland, Vol: 2, Pages: 197-199, ISSN: 2754-0022
<jats:p>The consequences of climate change pose a significant threat to health and healthcare systems globally. The increase in air pollution, temperatures and natural disasters along with the shift in patterns of infectious disease are leading to an increased disease burden.1,2 Unless urgent action is taken to mitigate climate change, the health consequences are projected to deteriorate further.3 Specific to vascular disease, the fluctuations in temperature and reduction in air quality have been associated with an increased cardiovascular morbidity and mortality.4 Thus, the continued impact of climate change, along with other disease epidemics such as diabetes, has the potential to increase the vascular disease burden. With this in mind, we need to work together as a vascular community to limit our contribution to climate change whilst continuing to manage our individual patients and vascular services.</jats:p>
Laura B, Smith S, Babber A, et al., 2023, Neuromuscular electrical stimulation as an adjunct to standard care in improving walking distances in intermittent claudication patients: the NESIC RCT, Efficacy and Mechanism Evaluation, Vol: 10, Pages: 1-101, ISSN: 2050-4365
BackgroundPeripheral arterial disease is common and associated with increased cardiovascular morbidity and mortality. While patients with peripheral arterial disease are known to benefit from supervised exercise therapy, it is not always available. Neuromuscular electrical stimulation devices may offer a similar benefit. A randomised controlled trial was required to ascertain whether such devices can benefit patients who receive supervised exercise therapy and those who do not.Objective(s)The primary objective was to assess the mean difference in absolute walking distance at 3 months in intermittent claudication patients receiving either a neuromuscular electrical stimulation device and local standard care (intervention), or local standard care alone (control).DesignA pragmatic, multicentre, randomised controlled trial stratified by centre.SettingSecondary-care National Health Service hospitals in the United Kingdom.ParticipantsPatients aged ≥18 years, with a diagnosis of intermittent claudication according to the Edinburgh Claudication Questionnaire and ankle–brachial pressure index (or stress test), without contraindications to neuromuscular electrical stimulation were deemed eligible to partake.InterventionsParticipants were randomised 1 : 1 to either local standard care or local standard care and neuromuscular electrical stimulation. Due to the nature of the intervention, it was unfeasible to blind the research nurse or participant to the study allocation.Main outcome measuresThe primary outcome measure was absolute walking distance measured by treadmill testing at 3 months. Secondary outcomes included change in initial claudication distance, quality of life, compliance with interventions and haemodynamic assessments.ResultsTwo hundred patients underwent randomisation, with 160 patients having analysable primary outcome data for the intention-to-treat analysis intervention (n = 80); control (n = 80). As the data were right-censored, a Tobit regression m
Adisa A, Bahrami-Hessari M, Bhangu A, et al., 2023, Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries, British Journal of Surgery, Vol: 110, Pages: 804-817, ISSN: 0007-1323
BackgroundHealthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.MethodsThis study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.ResultsIn phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.ConclusionThis is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries.
Hanna L, Borsky K, Abdullah AA, et al., 2023, Trends in Hospital Admissions, Operative Approaches, and Mortality Related to Abdominal Aortic Aneurysms in England Between 1998 and 2020., Eur J Vasc Endovasc Surg, Vol: 66, Pages: 68-76
OBJECTIVE: To assess trends in abdominal aortic aneurysm (AAA) hospital admissions, interventions, and aneurysm related mortality in England, and to examine the impact of endovascular repair on mortality for the years 1998 - 2020. METHODS: Hospital admission and operative approach (endovascular aortic aneurysm repair, or open surgical repair [OSR]) using Hospital Episodes Statistics (HES), and aneurysm related mortality data from the Office for National Statistics for England standardised to the 2013 European Standard Population, were analysed using linear regression and Joinpoint regression analyses. Aneurysm related mortality was compared between the pre-endovascular era (1998 - 2010) and the endovascular era (2011 - 2019). RESULTS: A declining trend in hospital admission incidence was observed, mainly due to a decline in ruptured admissions from 34.6 per 100 000 (95% confidence interval [CI] 33.5 - 35.6) to 13.5 per 100 000 (95% CI 12.9 - 14.2; βi = -1.04, r2 = .97, p < .001). Operative interventions have been declining over the last 23 years mainly due to the statistically significant decline in open procedures (41.2 per 100 000 in 2000 [95% CI 40 - 42.3] to 9.6 per 100 000 [95% CI 9.1 - 10.1]; βi = -1.92, r2 = .95; p < .001). There was an increasing trend toward endovascular procedures (5.8 per 100 000 [95% CI 5.3 - 6.2] in 2006 to 16.9 per 100 000 [95% CI 16.2 - 17.5] in 2020; βi = .82, r2 = .30, p = .040). Reductions in aneurysm related mortality due to AAAs were observed for males and females, irrespective of age and rupture status. CONCLUSION: A significant decrease in hospital admissions for AAAs was observed over the last 23 years in England, paralleled by a shift toward endovascular repair and a decline in OSR. Declines in aneurysm related mortality were observed overall, and in the endovascular era irrespective of age, sex, and rupture status.
Singh H, Agarwal L, Jani C, et al., 2023, Pulmonary hypertension associated mortality in the United States from 2003 to 2020: an observational analysis of time trends and disparities, Journal of Thoracic Disease, Vol: 15, Pages: 1-18, ISSN: 2072-1439
Background: Pulmonary hypertension (PH) is an independent risk factor for morbidity and mortality. In the last two decades, significant advances have been made in management of World Health Organization (WHO) group 1 PH. However, there are no approved targeted pharmacotherapies for PH secondary to left-sided heart diseases or chronic hypoxic lung diseases which are thought to account for more than 70–80% of the disease burden. No recent investigation has analyzed and compared the mortality burden related to WHO group 1 PH with the mortality burden with WHO groups 2–5 PH at the national level in the United States (US). We hypothesize that WHO group 1 PH-related mortality has improved over the last two decades in comparison to WHO groups 2–5 PH.Methods: In this study, we used data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) the underlying cause of death database to study age-standardized mortality rates related to PH in the US from 2003 to 2020.Results: A total of 126,526 deaths were recorded from PH in the US between 2003 and 2020. Across the study period, PH-related ASMR increased from 17.81 per million population in 2003 to 23.89 in 2020 with a percentage change (PC) of +34%. However, there are contrasting mortality trends in WHO group 1 PH when compared to WHO groups 2–5 PH. Data demonstrated a decline in mortality from group 1 PH regardless of gender. In contrast, an increase in mortality from WHO groups 2–5 PH was observed, accounting for the major proportion of the overall PH mortality burden in recent years.Conclusions: PH-related mortality continues to an increase primarily due to increase in mortality attributed to WHO groups 2–5 PH. These findings have notable public health implications. Screening and risk assessment tools for secondary PH, risk factor modification, and novel management strategies are vital to improve outcomes.
Punjwani S, Jaroenlapnopparat A, Jani C, et al., 2023, An estimate of the burden of pancreatic cancer globally and its comparison with different WHO regions using Global Burden of Disease Database: A retrospective population-based analysis, Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0732-183X
Singh H, Rupal A, Al Omari O, et al., 2023, Trends in pulmonary tuberculosis mortality between 1985 and 2018: an observational analysis, BMC Pulmonary Medicine, Vol: 23, Pages: 1-12, ISSN: 1471-2466
BackgroundPulmonary tuberculosis (TB) is a major source of global morbidity and mortality. Latent infection has enabled it to spread to a quarter of the world's population. The late 1980s and early 1990s saw an increase in the number of TB cases related to the HIV epidemic, and the spread of multidrug-resistant TB. Few studies have reported pulmonary TB mortality trends. Our study reports and compares trends in pulmonary TB mortality.MethodsWe utilized the World Health Organization (WHO) mortality database from 1985 through 2018 to analyze TB mortality using the International Classification of Diseases-10 codes. Based on the availability and quality of data, we investigated 33 countries including two countries from the Americas; 28 countries from Europe; and 3 countries from the Western Pacific region. Mortality rates were dichotomized by sex. We computed age-standardized death rates per 100,000 population using the world standard population. Time trends were investigated using joinpoint regression analysis.ResultsWe observed a uniform decrease in mortality in all countries across the study period except the Republic of Moldova, which showed an increase in female mortality (+ 0.12 per 100,000 population). Among all countries, Lithuania had the greatest reduction in male mortality (-12) between 1993–2018, and Hungary had the greatest reduction in female mortality (-1.57) between 1985–2017. For males, Slovenia had the most rapid recent declining trend with an estimated annual percentage change (EAPC) of -47% (2003–2016), whereas Croatia showed the fastest increase (EAPC, + 25.0% [2015–2017]). For females, New Zealand had the most rapid declining trend (EAPC, -47.2% [1985–2015]), whereas Croatia showed a rapid increase (EAPC, + 24.9% [2014–2017]).ConclusionsPulmonary TB mortality is disproportionately higher among Central and Eastern European countries. This communicable disease cannot be eliminated
Bhatt PS, Singh H, Jani C, et al., 2023, Trends in Carbon Monoxide Morbidity and Mortality in the United States From 1990 to 2019-an Observational Analysis Using the Global Burden of Disease (GBD) Database, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Hagroo A, Ali R, Goodall R, et al., 2023, Pelvic fracture incidence in EU15+countries: trends over a 30-year period, Publisher: OXFORD UNIV PRESS, ISSN: 0007-1323
Proctor DW, Goodall R, Borsky K, et al., 2023, Trends in the mortality, incidence and disability-adjusted life-years relating to appendicitis in EU15+countries: an observational study of the Global Burden of Disease database, 1990-2019, Publisher: OXFORD UNIV PRESS, Pages: III28-III28, ISSN: 0007-1323
Javed A, Machin M, Gwozdz A, et al., 2023, Meta-analysis of lytic catheter-based intervention for acute proximal deep vein thrombosis in the reduction of post-thrombotic syndrome, Journal of Vascular Surgery: Venous and Lymphatic Disorders, ISSN: 2213-333X
Al Omari O, Jani C, Ahmed A, et al., 2023, Lung Cancer Mortality in the United States between 1999 and 2019: An Observational Analysis of Disparities by Sex and Race, International Conference of the American-Thoracic-Society, Publisher: AMER THORACIC SOC, Pages: 612-616, ISSN: 1546-3222
Picciochi M, Glasbey JC, Li E, et al., 2023, Elective surgical services need to start planning for summer pressures, British Journal of Surgery, Vol: 110, Pages: 508-510, ISSN: 0007-1323
Bergner R, Onida S, Velineni R, et al., 2023, Metabolic profiling reveals changes in serum predictive of venous ulcer healing, Annals of Surgery, Vol: 277, Pages: e467-e474, ISSN: 0003-4932
Objective: The aim of this study was to identify potential biomarkers predictive of healing or failure to heal in a population with venous leg ulceration.Summary Background Data: Venous leg ulceration presents important physical, psychological, social and financial burdens. Compression therapy is the main treatment, but it can be painful and time-consuming, with significant recurrence rates. The identification of a reliable biochemical signature with the ability to identify nonhealing ulcers has important translational applications for disease prognostication, personalized health care and the development of novel therapies.Methods: Twenty-eight patients were assessed at baseline and at 20 weeks. Untargeted metabolic profiling was performed on urine, serum, and ulcer fluid, using mass spectrometry and nuclear magnetic resonance spectroscopy.Results: A differential metabolic phenotype was identified in healing (n = 15) compared to nonhealing (n = 13) venous leg ulcer patients. Analysis of the assigned metabolites found ceramide and carnitine metabolism to be relevant pathways. In this pilot study, only serum biofluids could differentiate between healing and nonhealing patients. The ratio of carnitine to ceramide was able to differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy.Conclusions: This study reports a metabolic signature predictive of healing in venous leg ulceration and presents potential translational applications for disease prognostication and development of targeted therapies.
Bhatt P, Salciccioli I, Singh H, et al., 2023, Asthma Mortality Trends Across EU15+Countries with a Focus on Age Disparities, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB160-AB160, ISSN: 0091-6749
Salciccioli I, Bhatt P, Shalhoub J, et al., 2023, Persistent sex and race disparities in anaphylaxis mortality in the US, 1999 to 2020: an analysis of the CDC Multiple Cause of Death database, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB222-AB222, ISSN: 0091-6749
The Vascular and Endovascular Research Network VERN Executive Committee, Hitchman L, Birmpili P, et al., 2023, The DEFINITE Audit: a prospective audit of diabetic foot debridement in theatre, Journal of Vascular Societies Great Britain and Ireland
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