Imperial College London
Alternate

MrJosephShalhoub

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.shalhoub Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khatri:2021:10.3390/jcm10194294,
author = {Khatri, A and Machin, M and Vijay, A and Salim, S and Shalhoub, J and Davies, A},
doi = {10.3390/jcm10194294},
journal = {Journal of Clinical Medicine},
title = {A Review of current and future antithrombotic strategies in surgical patients–leaving the graduated compression stockings behind?},
url = {http://dx.doi.org/10.3390/jcm10194294},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Venous thromboembolism (VTE) remains an important consideration within surgery, with recent evidence looking to refine clinical guidance. This review provides a contemporary update of existing clinical evidence for antithrombotic regimens for surgical patients, providing future directions for prophylaxis regimens and research. For moderate to high VTE risk patients, existing evidence supports the use of heparins for prophylaxis. Direct oral anticoagulants (DOACs) have been validated within orthopaedic surgery, although there remain few completed randomised controlled trials in other surgical specialties. Recent trials have also cast doubt on the efficacy of mechanical prophylaxis, especially when adjuvant to pharmacological prophylaxis. Despite the ongoing uncertainty in higher VTE risk patients, there remains a lack of evidence for mechanical prophylaxis in low VTE risk patients, with a recent systematic search failing to identify high-quality evidence. Future research on rigorously developed and validated risk assessment models will allow the better stratification of patients for clinical and academic use. Mechanical prophylaxis’ role in modern practice remains uncertain, requiring high-quality trials to investigate select populations in which it may hold benefit and to explore whether intermittent pneumatic compression is more effective. The validation of DOACs and aspirin in wider specialties may permit pharmacological thromboprophylactic regimens that are easier to administer.
AU  - Khatri,A
AU  - Machin,M
AU  - Vijay,A
AU  - Salim,S
AU  - Shalhoub,J
AU  - Davies,A
DO  - 10.3390/jcm10194294
PY  - 2021///
SN  - 2077-0383
TI  - A Review of current and future antithrombotic strategies in surgical patients–leaving the graduated compression stockings behind?
T2  - Journal of Clinical Medicine
UR  - http://dx.doi.org/10.3390/jcm10194294
UR  - http://hdl.handle.net/10044/1/92311
VL  - 10
ER  -
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