Imperial College London
Alternate

MrJosephShalhoub

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.shalhoub Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schuster-Bruce:2022,
author = {Schuster-Bruce, J and Jani, C and Goodall, R and Kim, D and Hughes, W and Salciccioli, J and Marshall, D and Shalhoub, J},
journal = {JAMA Otolaryngology-Head and Neck Surgery},
title = {A comparison of the burden of thyroid cancer between the European Union 15  countries, 1990-2019: estimates from the Global Burden of Disease Study},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance:The global incidence of thyroid cancer has been increasing rapidly and this has an attendant burden on health-systems. It is unclear how the burden of this disease differs between nations.Objective:To observe the trends in mortality, incidence and disability-adjusted life years (DALYs) from thyroid cancer between 1990-2019 in European Union (EU) 15+ nations.Design, Setting, Participants:Observational analysis using data obtained from the Global Burden of Disease (GBD) Study database. Countries of the EU15+ were included.Exposure:Thyroid cancer.Main Outcomes and Measures:Age-standarised incidence rates (ASIR), age-standardised mortality rates (ASMR) and disability-adjusted life years (DALYs) were extracted for individual EU15+ countries per sex for each of the years 1990-2019, and mortality-to-incidence indices (MII) were computed. Joinpoint regression analysis was used to describe the trends.Results:Thirteen of 19 countries showed an average annual percentage change (AAPC) increase in ASIR across the study period. Joinpoint regression analysis reveals largely plateauing ASIR trends in recent years across the majority of EU15+ nations since 1990. Australia, Belgium and the US are the only countries with increasing ASMR trends with positive AAPCs, whilst the remaining 16 countries show negative trends. DALYs decreased in all EU15+ countries except Australia, Denmark and the US.  Conclusions and Relevance:Overall, the burden of thyroid cancer across EU15+ countries appears to be reducing, evidenced by plateauing incidence rates and reductions in mortality and DALYs over the 30-year study period. However, the US and Australia demonstrate unfavorable, increasing ASMR and DALY trends. Ongoing observation is required to monitor how changes in international clinical practice guidelines impact upon thyroid cancer DALYs and mortality.
AU  - Schuster-Bruce,J
AU  - Jani,C
AU  - Goodall,R
AU  - Kim,D
AU  - Hughes,W
AU  - Salciccioli,J
AU  - Marshall,D
AU  - Shalhoub,J
PY  - 2022///
SN  - 2168-6181
TI  - A comparison of the burden of thyroid cancer between the European Union 15  countries, 1990-2019: estimates from the Global Burden of Disease Study
T2  - JAMA Otolaryngology-Head and Neck Surgery
ER  -
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