Imperial College London
Alternate

MrJosephShalhoub

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.shalhoub Website

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turner:2023:10.1016/j.jvsv.2022.09.003,
author = {Turner, B and Jasionowska, S and Machin, M and Javed, A and Gwozdz, A and Shalhoub, J and Onida, S and Davies, A},
doi = {10.1016/j.jvsv.2022.09.003},
journal = {Journal of vascular surgery. Venous and lymphatic disorders},
pages = {219--226},
title = {Systematic review and meta-analysis of exercise therapy for venous leg ulcer healing and recurrence},
url = {http://dx.doi.org/10.1016/j.jvsv.2022.09.003},
volume = {11},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective:National guidelines in the United Kingdom have recommended regular exercise for individuals with venous leg ulceration. However, data on the effects of exercise on ulcer healing and recurrence are sparse. In the present study, we aimed to quantify the evidence for exercise regarding venous ulcer healing with respect to the primary outcomes of the proportion of healed ulcers and rate of ulcer recurrence. The secondary outcomes were improvement in ulcer symptoms, ulcer healing time, quality of life, compliance, and adverse events reported.Methods:The review followed PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines using a registered protocol (CRD42021220925). The MEDLINE and Embase databases and Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, European Union Clinical Trials, and International Standard Randomised Controlled Trial Number registries were searched up to April 6, 2022 and included studies comparing exercise therapy and compression vs compression alone. Data for the proportion of healed ulcers were pooled using a fixed effects meta-analysis.Results:After screening 1046 reports, 7 were included, with 121 participants allocated to exercise therapy and 125 to compression alone. All the reports were of randomized controlled trials and had reported ulcer healing at 12 weeks, with a pooled relative risk of ulcer healing of 1.38 for exercise vs compression (95% confidence interval, 1.11-1.71). Only one study had reported on recurrence; thus, data pooling was not performed. No differences between exercise and usual care were demonstrated. Compliance with exercise ranged from 33% to 81%. The included studies demonstrated low enrollment and a high risk of bias. Also, most of the trials had failed to demonstrate any differences in activity completed between the intervention and control arms.Conclusions:A paucity of studies has examined leg ulcer recurrence after exercise programs, with no evidence to s
AU  - Turner,B
AU  - Jasionowska,S
AU  - Machin,M
AU  - Javed,A
AU  - Gwozdz,A
AU  - Shalhoub,J
AU  - Onida,S
AU  - Davies,A
DO  - 10.1016/j.jvsv.2022.09.003
EP  - 226
PY  - 2023///
SN  - 2213-3348
SP  - 219
TI  - Systematic review and meta-analysis of exercise therapy for venous leg ulcer healing and recurrence
T2  - Journal of vascular surgery. Venous and lymphatic disorders
UR  - http://dx.doi.org/10.1016/j.jvsv.2022.09.003
UR  - http://hdl.handle.net/10044/1/102831
VL  - 11
ER  -
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