Imperial College London

ProfessorJustinStebbing

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Cancer Medicine and Oncology
 
 
 
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Contact

 

j.stebbing Website CV

 
 
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Assistant

 

Mrs Maureen Francis +44 (0)20 7594 2793

 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Summary

Professor of Cancer Medicine and Oncology, Consultant Oncologist, Imperial College and Imperial College Healthcare NHS Trust.

Professor Justin Stebbing specialises in a range of malignancies, their treatment with immunotherapy (breast, GI and lung and clinical trials), having originally trained in medicine at Trinity College Oxford, where he gained a first class degree. After completion of junior doctor posts in Oxford, he undertook training and a residency programme at The Johns Hopkins Hospital in the US, returning to London to continue his career in oncology at The Royal Marsden and then St Bartholomew's Hospitals. Professor Stebbing’s original PhD research investigated the interplay between the immune system and cancer; he was appointed a senior lecturer in 2007, and a Professor in 2009.

Professor Stebbing has published over 600 peer-reviewed papers in journals such as the Lancet, New England Journal, Blood, the Journal of Clinical Oncology, Annals of Internal Medicine, as well as writing regularly for national newspapers and presenting new data on optimal cancer therapies at the major international conferences. His focus at Imperial is on new therapies in cancer, and the systemic management of patients with solid malignancies including a number of new biomarker-based approaches, with an emphasis on circulating tumour cells and cell free DNA. His laboratory work is concentrated on new druggable target discovery and gene regulation examining the role of non-coding RNAs in stem cells. Action Against Cancer logoThe charity Action Against Cancer www.aacancer.org has been set up to support Justin's work which concentrates on drug development and has the ambitious goal of developing cures.

He is a Fellow of the Royal College of Physicians and the Royal College of Pathologists, and sits on the advisory Boards of a number of international cancer committees. He chaired the World Vaccine Congress and the Irish Cancer Society oversight committee and has sat on editorial boards of a number of world leading general medical and cancer journals such as the Journal of Clinical Oncology; he was awarded the Silvia Lawler prize in 2015. Justin's team published in Nature Medicine the discovery of a new cancer-causing gene which we have now implicated in breast, gastro-intestinal, lung and other solid tumours. The National Institute for Health Research (NIHR) awarded Justin Stebbing its first translational research professorship in oncology, aiming to bridge the gap between the laboratory and the patient to ensure therapy is personalised. The focus of this is understanding why some patients with cancer relapse, and developing a program to reverse this and prevent it. With the excellent research record we have at Imperial College London and clinical expertise from Imperial College Healthcare NHS Trust, we believe we are ideally placed to achieve this.

He has an extensive clinical practice and links this to a wide number of translational research studies and immunotherapy trials including recent biosimilar studies. In 2016 Justin was internationally recognised with his appointment as Editor-in-Chief of Oncogene (Springer Nature's foremost cancer journal) and election to the American Society for Clinical Investigation. This year, he has led broad international collaborations to advance COVID-19 research.


Summary of Justin's Covid-19 work 

COVID-19 Work Summary (PDF)

BARICITINIB HITS PRIMARY AND KEY SECONDARY ENDPOINTS IN THE PHASE 3 NIAID ACTT-II TRIAL

DATA ON CYTOKINE SIGNATURES IN STAGES OF COVID PUBLISHED

Data on baricitinib linking AI, the clinic and laboratory published:

Baricitinib for covid-19 taken into large US randomised-controlled trials


NEW TREATMENT STRATEGIES (BARICITINIB) PUBLISHED IN THE LANCET JOURNALS TO TREAT COVID-19


Professor Stebbing discusses the role of biosimilars in the Journal of Clinical Oncology, increasing access to high value drugs

Read more in the Journal of Clinical Oncology

Sir Michael Parkinson meets Professor Justin Stebbing


Sir Michael Parkinson meets Professor Justin Stebbing from Action Against Cancer on Vimeo.

Justin gives a Talk with Pulitzer Prize Winner (For The Emperor Of All Maladies), Dr Siddhartha Mukherjee


Prof Stebbing gives a talk with Pulitzer Prize-winning author Siddhartha Mukherjee who wrote "The Emperor of Maladies"

Selected Publications

Journal Articles

Tabassum N, Cereser B, Stebbing J, 2020, A cell-cycle signature classifier for pan-cancer analysis, Oncogene, ISSN:0950-9232

Magbanua MJM, Hendrix LH, Hyslop T, et al., 2020, Serial analysis of circulating tumor cells in metastatic breast cancer receiving first-line chemotherapy., J Natl Cancer Inst

Stebbing J, Krishnan V, de Bono S, et al., 2020, Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients, EMBO Molecular Medicine, Vol:12, ISSN:1757-4676

Kumleben N, Bhopal R, Czypionka T, et al., 2020, Test, test, test for COVID-19 antibodies: the importance of sensitivity, specificity and predictive powers., Public Health, Vol:185, Pages:88-90

Richardson P, Griffin I, Tucker C, et al., 2020, Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (vol 395, pg e30, 2020), The Lancet, Vol:395, ISSN:0140-6736, Pages:1906-1906

Peng L, Zagorac S, Stebbing J, 2020, Managing patients with cancer in the COVID-19 era, European Journal of Cancer, Vol:132, ISSN:0959-8049, Pages:5-7

Gagliano T, Shah K, Gargani S, et al., 2020, PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression, Journal of Clinical Investigation, Vol:130, ISSN:0021-9738, Pages:3188-3204

Ottaviani S, Stebbing J, What is the best drug to treat COVID-19? The need for randomized controlled trials, Medicine, ISSN:1357-3039

Stebbing J, Mainwaring PN, Curigliano G, et al., 2020, Understanding the Role of Comparative Clinical Studies in the Development of Oncology Biosimilars, Journal of Clinical Oncology, Vol:38, ISSN:0732-183X, Pages:1070-+

Stebbing J, Phelan A, Griffin I, et al., 2020, COVID-19: combining antiviral and anti-inflammatory treatments, Lancet Infectious Diseases, Vol:20, ISSN:1473-3099, Pages:400-402

Richardson P, Griffin I, Tucker C, et al., 2020, Baricitinib as potential treatment for 2019-nCoV acute respiratory disease, The Lancet, Vol:395, ISSN:0140-6736, Pages:E30-E31

Jin Y, Bao H, Le X, et al., 2020, Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation (vol 39, pg 1846, 2020), Oncogene, Vol:39, ISSN:0950-9232, Pages:2027-2027

Bhimani J, Ball K, Stebbing J, 2020, Patient-derived xenograft models-the future of personalised cancer treatment, British Journal of Cancer, Vol:122, ISSN:0007-0920, Pages:601-602

Peng L, Qin B-D, Xiao K, et al., 2020, A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy, Oncoimmunology, Vol:9, ISSN:2162-402X

Chandrasinghe P, Cereser B, Moorghen M, et al., 2017, Role of SMAD proteins in colitis-associated cancer: from known to the unknown., Oncogene, Vol:37, ISSN:0950-9232, Pages:1-7

Harding V, Stebbing J, 2017, Liquorice: a treatment for all sorts?, Lancet Oncology, Vol:18, ISSN:1470-2045, Pages:1155-1155

Wendler F, Favicchio R, Simon T, et al., 2017, Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention, Oncogene, Vol:36, ISSN:0950-9232, Pages:877-884

Zanini E, Louis LS, Antony J, et al., 2017, The tumor suppressor protein OPCML potentiates anti-EGFR and anti-HER2 targeted therapy in HER2-positive ovarian and breast cancer., Molecular Cancer Therapeutics, Vol:16, ISSN:1535-7163, Pages:2246-2256

Stebbing J, Baranau Y, Baryash V, 2017, CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial (vol 18, pg 917, 2017), Lancet Oncology, Vol:18, ISSN:1470-2045, Pages:E433-E433

Craddock C, Cathcart P, Stebbing J, 2017, Chilli-too hot to handle?, Lancet Oncology, Vol:18, ISSN:1470-2045, Pages:1005-1005

Stebbing J, Baranau Y, Baryash V, et al., 2017, CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial, Lancet Oncology, Vol:18, ISSN:1470-2045, Pages:917-928

Cathcart P, Craddock C, Stebbing J, 2017, Fasting: starving cancer., Lancet Oncology, Vol:18, ISSN:1474-5488, Pages:431-431

Esteva FJ, Lee SJ, Stebbing J, et al., 2017, Phase I clinical trial comparing PK and safety of trastuzumab and its biosimilar candidate CT-P6, Breast, Vol:32, ISSN:0960-9776, Pages:S68-S69

Meijer LL, Frampton AE, Garajova I, et al., 2017, Circulating microRNAs as dynamic biomarkers of response to treatment with FOLFIRINOX combination therapy in advanced pancreatic ductal adenocarcinoma, The Lancet, Vol:389, ISSN:0140-6736, Pages:68-68

Boulianne B, Robinson ME, May PC, et al., 2017, Lineage-specific genes are prominent DNA damage hotspots during leukemic transformation of B-cell precursors, Cell Reports, Vol:18, ISSN:2211-1247, Pages:1687-1698

Askari A, Nachiappan S, Currie A, et al., 2017, The relationship between ethnicity, social deprivation and late presentation of colorectal cancerle, Cancer Epidemiology, Vol:47, ISSN:1877-7821, Pages:88-93

Page K, Guttery DS, Fernandez-Garcia D, et al., 2017, Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer, Clinical Chemistry, Vol:63, ISSN:0009-9147, Pages:532-541

Castellano L, Dabrowska A, Pellegrino L, et al., 2017, Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR, Nucleic Acids Research, Vol:45, ISSN:1362-4962, Pages:4401-4412

Balachandran K, Stebbing J, 2016, Turmeric: a spice for life?, Lancet Oncol, Vol:17, Pages:1639-1639

Tree AC, Harding V, Bhangu A, et al., 2016, The need for multidisciplinarity in specialist training to optimize future patient care, Nature Reviews Clinical Oncology, Vol:14, ISSN:1759-4774, Pages:508-517

Nachiappan S, Askari A, Mamidanna R, et al., 2016, Initiation of adjuvant chemotherapy within 8weeks of elective colorectal resection improves overall survival regardless of reoperation, Colorectal Disease, Vol:18, ISSN:1462-8910, Pages:1041-1049

Conference

Malczewska A, Frampton A, Prado MM, et al., 2020, Diagnosis and Assessment of Effectiveness of Surgical Resection of Small Bowel Neuroendocrine Tumours: The Roles of Circulating MicroRNAs, 17th Annual European-Neuroendocrine-Tumor-Society (ENETS) Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease, KARGER, Pages:145-145, ISSN:0028-3835

Pinato DJ, Stebbing J, Ishizuka M, et al., 2012, A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI), Elsevier, Pages:1013-1020, ISSN:1600-0641

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