Imperial College London
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ProfessorJustinStebbing

Faculty of Medicine, Department of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

j.stebbing Website CV

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Peng:2021:10.3389/fonc.2021.657545,
author = {Peng, L and Liang, W-H and Mu, D-G and Xu, S and Hong, S-D and Stebbing, J and Liang, F and Xia, Y},
doi = {10.3389/fonc.2021.657545},
journal = {Front Oncol},
title = {First-line treatment options for PD-L1-negative non-small cell lung cancer: a Bayesian network meta-analysis},
url = {http://dx.doi.org/10.3389/fonc.2021.657545},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: First-line treatment strategies for programmed death-ligand 1 (PD-L1) negative non-small cell lung cancer (NSCLC) patients include chemotherapy and combination with anti-angiogenesis drugs and/or immune checkpoint inhibitor. We conducted a Bayesian network meta-analysis to evaluate the efficacy of these therapeutic options. Methods: We included phase III randomized controlled trials comparing two or more treatments in the first-line setting for NSCLC, including data in PD-L1-negative patients. First-line strategies were compared and ranked based on the effectiveness in terms of overall survival (OS) and progression-free survival (PFS). A rank was assigned to each treatment after Markov Chain Monte Carlo analyses. Results: Fourteen trials involving 14 regimens matched our eligibility criteria. For OS, none of the treatment were significantly more effective than chemotherapy. Nivolumab plus ipilimumab plus chemotherapy was probably the best option based on analysis of the treatment ranking (probability = 30.1%). For PFS, nivolumab plus chemotherapy plus bevacizumab, atezolizumab plus chemotherapy plus bevacizumab, and atezolizumab plus chemotherapy were statistically superior to chemotherapy in pairwise comparison. Nivolumab plus chemotherapy plus bevacizumab was likely to be the preferred option based on the analysis of the treatment ranking (probability = 72.9%). Conclusions: Nivolumab plus chemotherapy, in combination with angiogenesis inhibition or anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), had maximal benefits for NSCLC patient of PD-L1-negative expression. These findings may facilitate individualized treatment strategies. Safety at an individual patient level should be considered in decision making. Further validation is warranted.
AU  - Peng,L
AU  - Liang,W-H
AU  - Mu,D-G
AU  - Xu,S
AU  - Hong,S-D
AU  - Stebbing,J
AU  - Liang,F
AU  - Xia,Y
DO  - 10.3389/fonc.2021.657545
PY  - 2021///
SN  - 2234-943X
TI  - First-line treatment options for PD-L1-negative non-small cell lung cancer: a Bayesian network meta-analysis
T2  - Front Oncol
UR  - http://dx.doi.org/10.3389/fonc.2021.657545
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34249693
UR  - http://hdl.handle.net/10044/1/90383
VL  - 11
ER  -
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