Emeritus ProfessorJonathanStoye

Stoye JP, Coffin JM, 2000, Reproductive biology - A provirus put to work, NATURE, Vol: 403, Pages: 715-+, ISSN: 0028-0836

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• Citations: 35

Stoye JP, 1999, The pathogenic potential of endogenous retroviruses: a sceptical view, TRENDS IN MICROBIOLOGY, Vol: 7, Pages: 430-430, ISSN: 0966-842X

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• Citations: 14

Cachón-González MB, San-José I, Cano A, Vega JA, García N, Freeman T, Schimmang T, Stoye JPet al., 1999, The <i>hairless</i> gene of the mouse:: Relationship of phenotypic effects with expression profile and genotype, DEVELOPMENTAL DYNAMICS, Vol: 216, Pages: 113-126, ISSN: 1058-8388

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• Citations: 50

Oliver PL, Stoye JP, 1999, Genetic analysis of <i>Gv1</i>, a gene controlling transcription of endogenous murine polytropic proviruses, JOURNAL OF VIROLOGY, Vol: 73, Pages: 8227-8234, ISSN: 0022-538X

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• Citations: 21

Begoña CachónGonzález M, SanJosé I, Cano A, Antonio Vega J, García N, Freeman T, Schimmang T, Stoye JPet al., 1999, The hairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype, Developmental Dynamics, Vol: 216, Pages: 113-126, ISSN: 1058-8388

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Takeuchi Y, Patience C, Magre S, Weiss RA, Banerjee PT, Le Tissier P, Stoye JPet al., 1998, Host range and interference studies of three classes of pig endogenous retrovirus, JOURNAL OF VIROLOGY, Vol: 72, Pages: 9986-9991, ISSN: 0022-538X

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• Citations: 351

Stoye J, 1998, No clear answers on safety of pigs as tissue donor source, LANCET, Vol: 352, Pages: 666-667, ISSN: 0140-6736

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• Citations: 40

Stoye JP, 1998, Fv1, the mouse retrovirus resistance gene, REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES, Vol: 17, Pages: 269-277, ISSN: 0253-1933

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• Citations: 47

Stoye JP, Le Tissier P, Takeuchi Y, Patience C, Weiss RAet al., 1998, Endogenous retroviruses: A potential problem for xenotransplantation?, XENOTRANSPLANTATION, Vol: 862, Pages: 67-74, ISSN: 0077-8923

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• Citations: 21

LeTissier P, Stoye JP, Takeuchi Y, Patience C, Weiss RAet al., 1997, Two sets of human-tropic pig retrovirus, NATURE, Vol: 389, Pages: 681-682, ISSN: 0028-0836

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• Citations: 335

Best S, LeTissier PR, Stoye JP, 1997, Endogenous retroviruses and the evolution of resistance to retroviral infection, TRENDS IN MICROBIOLOGY, Vol: 5, Pages: 313-318, ISSN: 0966-842X

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• Citations: 71

Stoye JP, 1997, Xenotransplantation. Proviruses pose potential problems., Nature, Vol: 386, Pages: 126-127, ISSN: 0028-0836

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Boeke JD, Stoye JP, 1997, Retrotransposons, Endogenous Retroviruses, and the Evolution of Retroelements

The retroelements are as diverse an assemblage of related molecular entities as can be found anywhere. With the exception of the retroviruses themselves, retroelements are genetic parasites that inhabit the genomes of all eukaryotes and many prokaryotes. The infectious retroviruses can be considered a highly evolved pinnacle on the complex phylogenetic tree that makes up the retroelements. The root of this tree is believed by many to be an ancient cellular reverse transcriptase gene, as originally proposed by Temin (1980), although this remains controversial. It is useful to consider the retroelements in comparison to the infectious retroviruses. The retroelement types, summarized in Table 1, include the endogenous retroviruses, the retrotransposons, the “retrotranscripts” (including the Alu-like sequences and the processed pseudogenes), and the prokaryotic retrons (also known as multicopy single-stranded DNAs [msDNAs]). Retroelements are known primarily as mobile DNA species integrated at various positions in the genomes of their host species, although most of them also have important extrachromosomal DNA forms. From the mitochondrial and chloroplast compartments of various organisms, the mobile group II introns (referred to here as retrointrons) and the retroplasmids are recognized as retroelements. Yet another major grouping of retroelements is the “pararetroviruses,” a group of true viruses with DNA genomes that, in a curious permutation of the retroviral life cycle, replicate via a cellular RNA intermediate but do not normally integrate into the host genome.

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Best S, LeTissier P, Towers G, Stoye JPet al., 1996, Positional cloning of the mouse retrovirus restriction gene Fv1, NATURE, Vol: 382, Pages: 826-829, ISSN: 0028-0836

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• Citations: 382

Mock BA, Stoye J, Spence J, Jackson I, Eppig JT, Fiedorek FT, Neumann PEet al., 1996, Mouse Chromosome 4, MAMMALIAN GENOME, Vol: 6, Pages: S73-S96, ISSN: 0938-8990

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• Citations: 12

STOYE JP, COFFIN JM, 1995, THE DANGERS OF XENOTRANSPLANTATION, NATURE MEDICINE, Vol: 1, Pages: 1100-1100, ISSN: 1078-8956

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• Citations: 60

LUSH IE, HORNIGOLD N, KING P, STOYE JPet al., 1995, THE GENETICS OF TASTING IN MICE .7. GLYCINE REVISITED, AND THE CHROMOSOMAL LOCATION OF SAC AND SOA, GENETICAL RESEARCH, Vol: 66, Pages: 167-174, ISSN: 0016-6723

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• Citations: 88

STOYE JP, KAUSHIK N, JEREMIAH S, BEST Set al., 1995, GENETIC-MAP OF THE REGION SURROUNDING THE RETROVIRUS RESTRICTION LOCUS, FV1, ON MOUSE CHROMOSOME-4, MAMMALIAN GENOME, Vol: 6, Pages: 31-36, ISSN: 0938-8990

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• Citations: 12

KAUSHIK N, STOYE JP, 1994, INTRACISTERNAL A-TYPE PARTICLE ELEMENTS AS GENETIC-MARKERS - DETECTION BY REPEAT ELEMENT VIRAL ELEMENT AMPLIFIED LOCUS-PCR, MAMMALIAN GENOME, Vol: 5, Pages: 688-695, ISSN: 0938-8990

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• Citations: 7

CACHONGONZALEZ MB, FENNER S, COFFIN JM, MORAN C, STOYE JP, BEST Set al., 1994, STRUCTURE AND EXPRESSION OF THE HAIRLESS GENE OF MICE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 91, Pages: 7717-7721, ISSN: 0027-8424

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• Citations: 151

RINCHIK EM, STOYE JP, FRANKEL WN, COFFIN J, KWON BS, RUSSELL LBet al., 1993, MOLECULAR ANALYSIS OF VIABLE SPONTANEOUS AND RADIATION-INDUCED ALBINO (C)-LOCUS MUTATIONS IN THE MOUSE, MUTATION RESEARCH, Vol: 286, Pages: 199-207, ISSN: 0921-8262

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• Citations: 37

GROOT PC, MOEN CJA, DIETRICH W, STOYE JP, LANDER ES, DEMANT Pet al., 1992, THE RECOMBINANT CONGENIC STRAINS FOR ANALYSIS OF MULTIGENIC TRAITS - GENETIC COMPOSITION, FASEB JOURNAL, Vol: 6, Pages: 2826-2835, ISSN: 0892-6638

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• Citations: 76

FRANKEL WN, LEE BK, STOYE JP, COFFIN JM, EICHER EMet al., 1992, CHARACTERIZATION OF THE ENDOGENOUS NONECOTROPIC MURINE LEUKEMIA VIRUSES OF NZB/B1NJ AND SM/J INBRED STRAINS, MAMMALIAN GENOME, Vol: 2, Pages: 110-122, ISSN: 0938-8990

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• Citations: 51

ABBOTT CM, BLANK R, EPPIG JT, FRIEDMAN JM, HUPPI KE, JACKSON I, MOCK BA, STOYE J, WISEMAN Ret al., 1992, MOUSE CHROMOSOME-4, MAMMALIAN GENOME, Vol: 3, Pages: S55-S64, ISSN: 0938-8990

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• Citations: 29

STOYE JP, MORONI C, COFFIN JM, 1991, VIROLOGICAL EVENTS LEADING TO SPONTANEOUS AKR THYMOMAS, JOURNAL OF VIROLOGY, Vol: 65, Pages: 1273-1285, ISSN: 0022-538X

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• Citations: 154

, 1990, A Linkage Map of Endogenous Murine Leukemia Proviruses, Genetics, Vol: 125, Pages: 455-455, ISSN: 0016-6731

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FRANKEL WN, STOYE JP, TAYLOR BA, COFFIN JMet al., 1990, A LINKAGE MAP OF ENDOGENOUS MURINE LEUKEMIA PROVIRUSES, GENETICS, Vol: 124, Pages: 221-236, ISSN: 0016-6731

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• Citations: 197

FRANKEL WN, STOYE JP, TAYLOR BA, COFFIN JMet al., 1989, GENETIC IDENTIFICATION OF ENDOGENOUS POLYTROPIC PROVIRUSES BY USING RECOMBINANT INBRED MICE, JOURNAL OF VIROLOGY, Vol: 63, Pages: 3810-3821, ISSN: 0022-538X

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• Citations: 128

FRANKEL WN, STOYE JP, TAYLOR BA, COFFIN JMet al., 1989, GENETIC-ANALYSIS OF ENDOGENOUS XENOTROPIC MURINE LEUKEMIA VIRUSES - ASSOCIATION WITH 2 COMMON-MOUSE MUTATIONS AND THE VIRAL RESTRICTION LOCUS FV-1, JOURNAL OF VIROLOGY, Vol: 63, Pages: 1763-1774, ISSN: 0022-538X

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• Citations: 135

Coffin JM, Stoye JP, Frankel WN, 1989, Genetics of endogenous murine leukemia viruses., Ann N Y Acad Sci, Vol: 567, Pages: 39-49, ISSN: 0077-8923

Inbred strains of mice contain in the genome 40-60 endogenous proviruses related to murine leukemia virus. To assess the genetic and pathogenic consequences of these to the host, we have developed a strategy to distinguish among the three different host-range subgroups--xenotropic, polytropic and modified polytropic--by using oligonucleotide probes specific for a polymorphic region in env. Each of these proteins detects a relatively small number of bands in a Southern blot, thus permitting us to enumerate all individual proviruses of this group. Using this approach, we have determined the distribution of different proviruses among inbred and recombinant inbred (RI) strains congenic or coisogenic for specific mutants. Using the RI results, we have been able to place over 100 proviruses on the mouse genetic map. A number of these are closely linked to well-characterized mutations, and we have been able to establish that at least one mutation, hr (hairless), was caused by a proviral insertion. If the other close linkages also prove to reflect causality, we estimate that up to 5% of recessive mutations in the mouse might be caused by insertion of proviruses of this group. Using a similar probe strategy, we have followed the evolution of murine leukemia viruses during spontaneous leukemogenesis in AKR mice. We have found that the final leukemogenic (MCF) virus is a recombinant of three different endogenous parents; an ecotropic virus, a polytropic virus that directs the gp70 region of env, and a xenotropic virus (identified as the inducible element Bxv-1) that directs the LTR. In addition to the recombinations, all such viruses also have a reduplication of the enhancer region of the LTR, compared to the endogenous parent. MCF viruses are created by these three genetic changes, which occur in a reproducible fashion and appear in the thymus between 10 and 14 weeks of age.

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