Imperial College London
Alternate

Emeritus ProfessorJonathanStoye

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor of Endogenous Retroviruses
 
 
 
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Contact

 

j.stoye Website

 
 
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Location

 

Francis Crick InstituteThe Francis Crick Institute

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Summary

 

Publications

Citation

BibTex format

@article{Kassiotis:2017:10.1098/rstb.2016.0277,
author = {Kassiotis, G and Stoye, JP},
doi = {10.1098/rstb.2016.0277},
journal = {PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES},
title = {Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer},
url = {http://dx.doi.org/10.1098/rstb.2016.0277},
volume = {372},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Like all other mammals, humans harbour an astonishing number of endogenous retroviruses (ERVs), as well as other retroelements, embedded in their genome. These remnants of ancestral germline infection with distinct exogenous retroviruses display various degrees of open reading frame integrity and replication capability. Modern day exogenous retroviruses, as well as the infectious predecessors of ERVs, are demonstrably oncogenic. Further, replication-competent ERVs continue to cause cancers in many other species of mammal. Moreover, human cancers are characterized by transcriptional activation of human endogenous retroviruses (HERVs). These observations conspire to incriminate HERVs as causative agents of human cancer. However, exhaustive investigation of cancer genomes suggests that HERVs have entirely lost the ability for re-infection and thus the potential for insertional mutagenic activity. Although there may be non-insertional mechanisms by which HERVs contribute to cancer development, recent evidence also uncovers potent anti-tumour activities exerted by HERV replication intermediates or protein products. On balance, it appears that HERVs, despite their oncogenic past, now represent potential targets for immune-mediated anti-tumour mechanisms.
AU  - Kassiotis,G
AU  - Stoye,JP
DO  - 10.1098/rstb.2016.0277
PY  - 2017///
SN  - 0962-8436
TI  - Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer
T2  - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
UR  - http://dx.doi.org/10.1098/rstb.2016.0277
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000410316600014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/61550
VL  - 372
ER  -
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