Publications
70 results found
Strid J, McLean WHI, Irvine AD, 2016, Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol: 136, Pages: 561-564, ISSN: 0022-202X
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- Citations: 13
Strid J, 2015, Skin perturbations, stress surveillance and atopy, 51st Congress of the European-Societies-of-Toxicology (EUROTOX), Publisher: Elsevier, Pages: S42-S42, ISSN: 0378-4274
Seoane RC, Crawford G, Strid J, 2014, The scope of skin-induced lymphoid stress-surveillance, Publisher: WILEY-BLACKWELL, Pages: 171-171, ISSN: 0019-2805
Giacomassi C, Ling GS, Strid J, et al., 2014, Complement C3 exacerbates skin inflammation in a murine model of imiquimod-induced psoriasis, IMMUNOLOGY, Vol: 143, Pages: 120-120, ISSN: 0019-2805
Crawford GH, Seoane RC, Strid J, 2014, Lymphoid stress-surveillance promotes protective IgE responses in the skin, Publisher: WILEY-BLACKWELL, Pages: 78-78, ISSN: 0019-2805
Dalessandri T, Seoane RC, Strid J, 2014, IL-13 has prominent effects on skin epithelia and significantly protects against cutaneous carcinogenesis, Publisher: WILEY-BLACKWELL, Pages: 109-109, ISSN: 0019-2805
Hayes M, Strid J, 2014, IgE effector cells accumulate in inflamed skin and IgE strongly promotes inflammation-driven skin carcinogenesis, IMMUNOLOGY, Vol: 143, Pages: 169-169, ISSN: 0019-2805
Strid KJ, Dalessandri T, 2014, Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer, Frontiers in Immunology, Vol: 5, ISSN: 1664-3224
Dalessandri T, Strid J, 2013, Epithelial stress and DNA- damage induce a rapid Type 2 immune response with high levels of IgE, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 31-31, ISSN: 0019-2805
Strid J, Sobolev O, Filler R, et al., 2012, Integration of pathways initiating early tumour-surveillance with atopic IgE responses, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 169-169, ISSN: 0019-2805
Strid J, 2012, The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy (December, pg 1293, 2011), SCIENCE, Vol: 335, Pages: 538-538, ISSN: 0036-8075
Strid J, Sobolev O, Zafirova B, et al., 2011, The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy, Science, Vol: 334, Pages: 1293-1297
Hunt B, Woolf R, Strid J, et al., 2011, Defining novel afferent signals in the lymphoid stress surveillance response, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 132-132, ISSN: 0019-2805
Sobolev O, Strid J, Hayday A, 2010, Local and systemic consequences of lymphoid stress-surveillance by gd T cells, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 151-151, ISSN: 0019-2805
Hayday A, Turchinovich G, Michel M-L, et al., 2010, The construction and operation of lymphoid stress-surveillance, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 27-27, ISSN: 0019-2805
Thompson RL, Miles LM, Lunn J, et al., 2010, Peanut sensitisation and allergy: influence of early life exposure to peanuts, BRITISH JOURNAL OF NUTRITION, Vol: 103, Pages: 1278-1286, ISSN: 0007-1145
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- Citations: 22
Thompson RL, Miles LM, Lunn J, et al., 2010, The impact of early-life exposure to food allergens on the subsequent development of sensitisation and allergy to foods, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 69, Pages: E118-E118, ISSN: 0029-6651
Zinelli C, Caffarelli C, Strid J, et al., 2009, Measurement of nitric oxide and 8-isoprostane in exhaled breath of children with atopic eczema, CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol: 34, Pages: 607-612, ISSN: 0307-6938
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- Citations: 29
Strid J, Tigelaar RE, Hayday AC, 2009, Skin immune surveillance by T cells-A new order?, SEMINARS IN IMMUNOLOGY, Vol: 21, Pages: 110-120, ISSN: 1044-5323
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- Citations: 41
Strid J, Binda E, Hayday A, 2008, Tissue-surveillance responses and the impact on adaptive immunity, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 135-135, ISSN: 0019-2805
Roberts S, Silberzahn T, Filler R, et al., 2008, Local immune influences on cutaneous carcinogenesis, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 47-47, ISSN: 0019-2805
Woodward M, Barbee SD, Mention JJ, et al., 2008, Biochemical analysis of Skint-1, a novel immunomodulatory protein expressed in thymus and skin, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 135-136, ISSN: 0019-2805
Jones HE, Strid J, Osman M, et al., 2008, The role of β<sub>2</sub> integrins and lipopolysaccharide-binding protein in the phagocytosis of dead <i>Neisseria meningitidis</i>, CELLULAR MICROBIOLOGY, Vol: 10, Pages: 1634-1645, ISSN: 1462-5814
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- Citations: 8
Strid J, Filler R, Roberts S, et al., 2008, NKG2D-ligand upregulation promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis, International Investigative Dermatology Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S179-S179, ISSN: 0022-202X
Strid J, Roberts SJ, Filler RB, et al., 2008, Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis., Nat Immunol., Vol: 9, Pages: 146-154
Yates A, Chan C, Strid J, et al., 2007, Reconstruction of cell population dynamics using CFSE, BMC Bioinformatics, Vol: 8, ISSN: 1471-2105
Strid J, Tan LA, Strobel S, et al., 2007, Epicutaneous Immunization with Type II Collagen Inhibits both Onset and Progression of Chronic Collagen-Induced Arthritis, PLOS One, Vol: 2, ISSN: 1932-6203
Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias. In this study, we investigate whether the autoimmune inflammatory response of chronic collagen-induced arthritis (CCIA) in DBA/1-TCR-beta Tg mice can be modified by epicutaneous immunization. We show that epicutaneous immunization with type II collagen (CII) inhibited development and progression of CCIA and, importantly, also ameliorated ongoing disease as indicated by clinical scores of disease severity, paw swelling and joints histology. Treated mice show reduced CII-driven T cell proliferation and IFN-gamma production, as well as significantly lower levels of CII-specific IgG2a serum antibodies. In contrast, CII-driven IL-4 production and IgE antibody levels were increased consistent with skewing of the CII response from Th1 to Th2 in treated mice. IL-4 production in treated mice was inversely correlated with disease severity. Moreover, T cells from treated mice inhibited proliferation and IFN-gamma production by T cells from CCIA mice, suggesting induction of regulatory T cells that actively inhibit effector responses in arthritic mice. The levels of CD4(+)CD25(+) T cells were however not increased following epicutaneous CII treatment. Together, these results suggest that epicutaneous immunization may be used as an immune-modulating procedure to actively re-programme pathogenic Th1 responses, and could have potential as a novel specific and simple treatment for chronic autoimmune inflammatory diseases such as rheumatoid arthritis.
Strid J, Callard R, Strobel S, 2006, Epicutaneous immunization converts subsequent and established antigen-specific T helper type 1 (Th1) to Th2-type responses, IMMUNOLOGY, Vol: 119, Pages: 27-35, ISSN: 0019-2805
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- Citations: 35
Hayday AC, Strid J, Vermijlen D, et al., 2006, The biology and clinical application of tumor surveillance by unconventional T cells., 29th Annual San Antonio Breast Cancer Symposium, Publisher: SPRINGER, Pages: S2-S2, ISSN: 0167-6806
Strid J, Strobel S, 2005, Skin barrier dysfunction and systemic sensitization to allergens through the skin., Curr Drug Targets Inflamm Allergy, Vol: 4, Pages: 531-541, ISSN: 1568-010X
Most allergic, atopic and hypersensitive reactions are associated with Th2-biased immune responses and allergen-specific IgE antibodies. Pathological allergic disorders are on an alarming increase in the industrialized world. Understanding the mechanism of primary sensitization to allergens is important in elucidating the pathogenesis of these diseases and for possibly preventing their development. In this article, we review recent information supporting that epidermal allergen exposure may contribute to systemic allergic diseases and that atopy may be secondary to skin barrier dysfunction in some dermatoses. The skin is an active immunological organ, which functions as a primary defence and biosensor to the external environment. The critical permeability barrier function is mediated by the outmost layer of the epidermis, the stratum corneum. Perturbation of the stratum corneum initiates a chain of event, which activates homeostatic responses in the underlying epidermis. Repeated barrier-disruption, whether environmentally or genetically determined, may however stimulate signaling cascades that lead to inflammation and epidermal hyperplasia. Skin barrier dysfunction may also allow entry of allergens, which can lead to primary systemic sensitization. The altered epidermal microenvironment in barrier-disrupted skin appears to be particularly well suited for the induction of potent Th2-type responses with production of allergen-specific IgE. Epidermal exposure to food antigens can prevent the normal induction of oral tolerance and also lead to airway eosinophilia following inhalation. Exposure to allergens on barrier-disrupted skin may as such serve as a natural sensitization pathway for food allergy and respiratory allergic disease.
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