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@article{Silva-Santos:2018:10.3389/fimmu.2018.00851,
author = {Silva-Santos, B and Strid, J},
doi = {10.3389/fimmu.2018.00851},
journal = {FRONTIERS IN IMMUNOLOGY},
title = {Working in "NK Mode": Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by gamma delta T Cells},
url = {http://dx.doi.org/10.3389/fimmu.2018.00851},
volume = {9},
year = {2018}
}

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TY  - JOUR
AB  - Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes. For γδ T cells, NKRs play critical roles in discriminating stressed (transformed or infected) cells from their healthy counterparts, as proposed in the “lymphoid stress-surveillance” theory. Whereas the main physiologic role is seemingly fulfilled by natural killer group 2 member D, constitutively expressed by γδ T cells, enhancement of their therapeutic potential may rely on natural cytotoxicity receptors (NCRs), like NKp30 or NKp44, that can be induced selectively on human Vδ1+ T cells. Here, we review the contributions of NCRs, NKG2D, and their multiple ligands, to γδ T cell biology in mouse and human.
AU  - Silva-Santos,B
AU  - Strid,J
DO  - 10.3389/fimmu.2018.00851
PY  - 2018///
SN  - 1664-3224
TI  - Working in "NK Mode": Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by gamma delta T Cells
T2  - FRONTIERS IN IMMUNOLOGY
UR  - http://dx.doi.org/10.3389/fimmu.2018.00851
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000430743300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/59915
VL  - 9
ER  -

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