Imperial College London
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ProfessorJessicaStrid

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Cellular Immunology
 
 
 
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Contact

 

+44 (0)20 3313 1475j.strid

 
 
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Location

 

9N15BCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hayes:2020:10.7554/eLife.51862,
author = {Hayes, MD and Ward, S and Crawford, G and Castro, Seoane R and Jackson, WD and Kipling, D and Voehringer, D and Dunn-Walters, D and Strid, KJ},
doi = {10.7554/eLife.51862},
journal = {eLife},
pages = {1--24},
title = {Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth},
url = {http://dx.doi.org/10.7554/eLife.51862},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IgE is the least abundant circulating antibody class but is constitutively present in healthy tissues bound to resident cells via its high-affinity receptor, FcεRI. The physiological role of endogenous IgE antibodies is unclear but it has been suggested that they provide host protection against a variety of noxious environmental substances and parasitic infections at epithelial barrier surfaces. Here we show, in mice, that skin inflammation enhances levels of IgE antibodies that have natural specificities and a repertoire, VDJ rearrangements and CDRH3 characteristics similar to those of IgE antibodies in healthy tissue. IgE-bearing basophils are recruited to inflamed skin via CXCL12 and thymic stromal lymphopoietin (TSLP)/IL-3-dependent upregulation of CXCR4. In the inflamed skin, IgE/FcεRI-signalling in basophils promotes epithelial cell growth and differentiation, partly through histamine engagement of H1R and H4R. Furthermore, this IgE response strongly drives tumour outgrowth of epithelial cells harbouring oncogenic mutation. These findings indicate that natural IgE antibodies support skin barrier defences, but that during chronic tissue inflammation this role may be subverted to promote tumour growth.
AU  - Hayes,MD
AU  - Ward,S
AU  - Crawford,G
AU  - Castro,Seoane R
AU  - Jackson,WD
AU  - Kipling,D
AU  - Voehringer,D
AU  - Dunn-Walters,D
AU  - Strid,KJ
DO  - 10.7554/eLife.51862
EP  - 24
PY  - 2020///
SN  - 2050-084X
SP  - 1
TI  - Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.51862
UR  - https://elifesciences.org/articles/51862
UR  - http://hdl.handle.net/10044/1/76505
VL  - 9
ER  -
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