Imperial College London
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ProfessorJessicaStrid

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Cellular Immunology
 
 
 
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Contact

 

+44 (0)20 3313 1475j.strid

 
 
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Location

 

9N15BCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pereira:2020:10.1038/s41590-020-0643-3,
author = {Pereira, B and De, Maeyer RPH and Covre, LP and Nehar-Belaid, D and Lanna, A and Ward, S and Marches, R and Chambers, ES and Gomes, DCO and Riddell, NE and Maini, MK and Teixeira, VH and Janes, SM and Gilroy, DW and Larbi, A and Mabbott, NA and Ucar, D and Kuchel, GA and Henson, SM and Strid, J and Lee, JH and Banchereau, J and Akbar, AN},
doi = {10.1038/s41590-020-0643-3},
journal = {Nature Immunology},
pages = {684--694},
title = {Sestrins induce natural killer function in senescent-like CD8(+) T cells},
url = {http://dx.doi.org/10.1038/s41590-020-0643-3},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aging is associated with remodeling of the immune system to enable the maintenance of life-long immunity. In the CD8+ T cell compartment, aging results in the expansion of highly differentiated cells that exhibit characteristics of cellular senescence. Here we found that CD27−CD28−CD8+ T cells lost the signaling activity of the T cell antigen receptor (TCR) and expressed a protein complex containing the agonistic natural killer (NK) receptor NKG2D and the NK adaptor molecule DAP12, which promoted cytotoxicity against cells that expressed NKG2D ligands. Immunoprecipitation and imaging cytometry indicated that the NKG2D–DAP12 complex was associated with sestrin 2. The genetic inhibition of sestrin 2 resulted in decreased expression of NKG2D and DAP12 and restored TCR signaling in senescent-like CD27−CD28−CD8+ T cells. Therefore, during aging, sestrins induce the reprogramming of non-proliferative senescent-like CD27−CD28−CD8+ T cells to acquire a broad-spectrum, innate-like killing activity.
AU  - Pereira,B
AU  - De,Maeyer RPH
AU  - Covre,LP
AU  - Nehar-Belaid,D
AU  - Lanna,A
AU  - Ward,S
AU  - Marches,R
AU  - Chambers,ES
AU  - Gomes,DCO
AU  - Riddell,NE
AU  - Maini,MK
AU  - Teixeira,VH
AU  - Janes,SM
AU  - Gilroy,DW
AU  - Larbi,A
AU  - Mabbott,NA
AU  - Ucar,D
AU  - Kuchel,GA
AU  - Henson,SM
AU  - Strid,J
AU  - Lee,JH
AU  - Banchereau,J
AU  - Akbar,AN
DO  - 10.1038/s41590-020-0643-3
EP  - 694
PY  - 2020///
SN  - 1529-2908
SP  - 684
TI  - Sestrins induce natural killer function in senescent-like CD8(+) T cells
T2  - Nature Immunology
UR  - http://dx.doi.org/10.1038/s41590-020-0643-3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000522383000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41590-020-0643-3
UR  - http://hdl.handle.net/10044/1/84728
VL  - 21
ER  -
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