Imperial College London
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ProfessorJessicaStrid

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Cellular Immunology
 
 
 
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Contact

 

+44 (0)20 3313 1475j.strid

 
 
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Location

 

9N15BCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gaya:2017:10.1016/j.cell.2017.11.036,
author = {Gaya, M and Barral, P and Burbage, M and Aggarwal, S and Montaner, B and Warren, Navia A and Aid, M and Tsui, C and Maldonado, P and Nair, U and Ghneim, K and Fallon, PG and Sekaly, R-P and Barouch, DH and Shalek, AK and Bruckbauer, A and Strid, J and Batista, FD},
doi = {10.1016/j.cell.2017.11.036},
journal = {Cell},
pages = {517--533.e20},
title = {Initiation of antiviral B cell Immunity relies on innate signals from spatially positioned NKT cells},
url = {http://dx.doi.org/10.1016/j.cell.2017.11.036},
volume = {172},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - B cells constitute an essential line of defense from pathogenic infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although this process is known to be regulated by follicular helper T (TfH) cells, the mechanism by which B cells initially seed germinal center reactions remains elusive. We found that NKT cells, a population of innate-like T lymphocytes, are critical for the induction of B cell immunity upon viral infection. The positioning of NKT cells at the interfollicular areas of lymph nodes facilitates both their direct priming by resident macrophages and the localized delivery of innate signals to antigen-experienced B cells. Indeed, NKT cells secrete an early wave of IL-4 and constitute up to 70% of the total IL-4-producing cells during the initial stages of infection. Importantly, the requirement of this innate immunity arm appears to be evolutionarily conserved because early NKT and IL-4 gene signatures also positively correlate with the levels of neutralizing antibodies in Zika-virus-infected macaques. In conclusion, our data support a model wherein a pre-TfH wave of IL-4 secreted by interfollicular NKT cells triggers the seeding of germinal center cells and serves as an innate link between viral infection and B cell immunity.
AU  - Gaya,M
AU  - Barral,P
AU  - Burbage,M
AU  - Aggarwal,S
AU  - Montaner,B
AU  - Warren,Navia A
AU  - Aid,M
AU  - Tsui,C
AU  - Maldonado,P
AU  - Nair,U
AU  - Ghneim,K
AU  - Fallon,PG
AU  - Sekaly,R-P
AU  - Barouch,DH
AU  - Shalek,AK
AU  - Bruckbauer,A
AU  - Strid,J
AU  - Batista,FD
DO  - 10.1016/j.cell.2017.11.036
EP  - 533
PY  - 2017///
SN  - 0092-8674
SP  - 517
TI  - Initiation of antiviral B cell Immunity relies on innate signals from spatially positioned NKT cells
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2017.11.036
UR  - http://hdl.handle.net/10044/1/55577
VL  - 172
ER  -
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