Imperial College London

DrJessicaStrid

Faculty of MedicineDepartment of Immunology and Inflammation

Reader in Cellular Immunology
 
 
 
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Contact

 

+44 (0)20 3313 1475j.strid

 
 
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Location

 

9N15BCommonwealth BuildingHammersmith Campus

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Summary

 

Overview

During my PhD study, I was among the first to demonstrate that systemic sensitization to food proteins can occur through atopic (barrier-disrupted) skin and that this can break oral tolerance. The significance being that exposure to allergens on eczematous skin may initiate ‘the atopic march’. This concept was published in a series of papers in immunology and allergy journals. These findings also led to important clinical studies in children (Du Toit-G et al., N Engl J Med 2015, 2016). I was appointed as member of the ‘expert advice’ committee commissioned by the UK Food Standard Agency that guided the government to implement new policies in 2009 (http://www.food.gov.uk/policy-advice/allergyintol/peanutspregnancy). My work also led to a successful patent on ‘skin immunization system’.

As a post-doctoral fellow, I delved deeper into skin immunity and demonstrated that skin resident T cells can be activated by sole recognition of autologous stress-molecules on epithelial cells and that intraepithelial T cells are key for host protection against cutaneous carcinogenesis (Nat Immunol 2008). These findings underpin the tumour immune-surveillance hypothesis and were a paradigm shift in the field at the time. I subsequently showed that the intraepithelial T cell response to stress-ligands also induces potent type-2 and IgE responses (Science 2011). The demonstration of links between pathways initiating early phases of tumour-surveillance and those initiating atopic IgE responses was an important conceptual breakthrough. As a result, I was awarded the Hardiman-Redon prize for outstanding contribution to cancer research.

Over the last ~ 6 years I have continued to study tissue immune-surveillance in the skin and particularly the role of type-2 immunity in tissue homeostasis, epidermal integrity, inflammation and carcinogenesis. Recent key findings include the role of IL-13 in T cell-epithelial cell cross-communication and regulation of epithelial cell transit through the skin (Nat Commun 2016); and the discovery of a novel role for IgE in protecting against epithelial cell damage caused by environmental DNA-damaging xenobiotics (Nat Immunol 2018). These findings have shed new light on the role of this ancient immunoglobulin and raised wide interest (‘News and Views, Nat Immunol; ‘Research Highlight’ Nat Review Immunol; global press coverage).

Ongoing research projects:

  • Defining initiation of 'lymphoid stress-surveillance' in the tissue and its integration with downstream innate and adaptive immunity
  • Identifying the mechanism(s) of IgE mediated tissue immune-surveillance
  • Characterising the IgE/FcεRI axis in human skin cancer
  • Investigating the role of B cells and characterising the immunoglobulin repertoire in human skin cancer
  • Understanding the function of the IL-33/ST2 pathway in skin homeostasis, epithelial repair and tissue inflammation
  • Exploring how the immune system aids DNA-repair processes
  • Characterising the role of eosinophils in tissue homeostasis and cancer
  • Identifying how complement proteins regulate tissue inflammation and cancer
  • Understanding how tissue resident immune cells communicate with epithelial cells and thus aid their differentiation, turn-over and movement through the tissue

Guest Lectures

Invited speaker at the Keystone Symposia on Skin-Immune Crosstalk, Colorado, USA, February 2021 – Cancelled due to COVID-19, 2021

Invited keynote speaker at the EAACI Immunology Winter School, Digital, 2021, 2021

Invited speaker at the Gordon Research Conference on Epithelial Differentiation and Keratinization, Barcelona, Spain, 2021 – delayed due to COVID-19, 2021

Invited speaker at the Gordon Research Conference on Food Allergy and Type 2 Immunity, California, USA, 2020, 2020

Lecture for the ‘Immunologisches Kolloquium” seminar series at Hannover Medical School, Germany, 2020, 2020

Invited speaker at the Cancer Immunology Symposium, CRICK, London, UK, 2019, 2019

Invited speaker at the ‘Type 2 Immunity in Homeostasis and Disease’ conference, Bruges, Belgium, 2019, 2019

Invited speaker at the European Academy of Allergy and Clinical Immunology Congress, Lisbon, Portugal, 2019, 2019

Invited speaker at the Nature Conference ‘Grand Challenges in Immunology: Immunotherapy for Cancer and Beyond’, Qingdao, China, 2019, 2019

Invited speaker at the ‘IIT Symposium, UCL, London, UK, 2019, 2019

Invited speaker at the ‘From Lab to Clinic: Generating New Therapeutic Targets for Unmet Needs’ meeting, Oxford, UK, 2019, 2019

Invited speaker at the ‘West of Scotland Immunology Group Showcase Event’, Glasgow, UK, 2019, 2019

Invited speaker at the Key Symposium on ‘The Origin of Cancer’, Stockholm, Sweden, 2019, 2019

Invited speaker at the British Society for Immunology Congress, Liverpool, UK, 2019, 2019

Invited speaker at the ‘ 120th International Titisee Conference’ on ‘Evolution of immune defence mechanisms’, Titisee, Germany, 2019, 2019

Invited speaker at EMBO workshop ‘Perspectives on skin cancer prevention’, Les Diablerets, Switzerland, 2018, 2018

Invited Chair for keynote lecture, European Congress of Immunology, Amsterdam, 2018, 2018

Lecture at the CRICK, London, UK, 2018, 2018

Lecture at the Institute of Infection and Immunity at St George's, University of London, UK, 2018, 2018

Lecture at the Manchester Immunology Group BSI seminar series, University of Manchester, UK, 2018, 2018

Lecture at the Edinburgh Immunology Group seminar series, University of Edinburgh, UK, 2018, 2018

Lecture at the CRICK for postdocs on ‘careers’, London, UK, 2018, 2018

Lecture at the South Wales Immunology Group seminar series, Cardiff, UK, 2018, 2018

Lecture at the Blizard Institute, Queen Mary University of London, London, UK, 2018, 2018

Lecture at the ‘Immunology North East’ seminar series group at Newcastle University, UK, 2018, 2018

Lecture at seminar series, University of Surrey, UK, 2018, 2018

Lecture at the ‘LEO Foundation Skin Immunology Research Center’, University of Copenhagen, Denmark, 2018, 2018

Lecture at the Wellcome’s Researcher Meeting on Immunology and Infection Biology, UK, 2018, 2018

Lecture at the BSI Immunology seminar series, Institute of Immunology and Immunotherapy, University of Birmingham, UK, 2017, 2017

Invited speaker at the Medical Research Club, London, UK, 2017, 2017

Lecture at the International Center for Infectiologie Research (CIRI), Inserm, Lyon, France, 2017, 2017

Invited speaker at the British Society for Immunology Congress, Brighton, UK, 2017, 2017

Invited Chair for 2 sessions at the British Society for Immunology Congress, Brighton, UK, 2017, 2017

Public seminar at Imperial College London Festival, London, UK, 2016, 2016

Lecture at the Cancer Sciences Seminar Series, University of Southampton, Southampton, UK, 2016, 2016

Invited Chair for 2 sessions at the British Society for Immunology Congress, Brighton, UK, 2016, 2016

CRUK lab tour and talk for sponsors, Imperial College London, London, UK, 2016, 2016

Lecture at CRUK Cancer Immunology workshop, Imperial College London, London, UK, 2016, 2016

Invited speaker at the European Society for Dermatological Research Congress, Rotterdam, Holland, 2015, 2015

Lecture at the Tayside Immunology Group/Cell signalling and Immunology Division Seminar Series, Dundee, UK, 2015, 2015

Invited speaker at the British Society for Rheumatology Congress, Manchester, UK, 2015, 2015

Lecture at the ‘Wright-Fleming Institute Seminar Series’, St Mary, Imperial College London, UK, 2015, 2015

Invited speaker at the Congress of European Societies of Toxicology, EUROTOX, Porto, Portugal, 2015, 2015

Lecture at the Wellcome Trust’s Researcher Meeting in ‘cell biology and physiology in health and disease’, Edinburgh, UK, 2015, 2015

Lecture at ‘Stem Cells @ Lunch’, King’s College London, UK, 2014, 2014

Lecture at the Division of Asthma, Allergy & Lung Biology, King’s College London, UK, 2014, 2014

Lecture at the ‘Immune Systems Seminars’ at Barts and the London Medical School, Queen Mary College, UK, 2014, 2014

Keynote speaker at ‘Immunobiology Symposium’, Glasgow University, Glasgow, UK, 2014, 2014

Lecture at the ‘Instituto De Medicina Molecular’, Lisbon, Portugal, 2013, 2013

Lecture at London Research Institute, Cancer Research UK, 2013, 2013

Lecture at the ‘Bristol Immunology Group’, Bristol, UK, 2013, 2013

Lecture at the Immunology Section, Glasgow University, Glasgow, UK, 2013, 2013

Lecture at CRICK Symposium, Wellcome Trust, London, UK, 2012, 2012

Lecture at the ‘John Humphrey Seminar Series, Imperial College London, UK, 2012, 2012

Lecture at the London Research Institute 10 year anniversary Symposium, Royal College of Surgeons, London, UK, 2012, 2012

Invited speaker at the European Network of Immunology Institutes summer school in Advanced Immunology, Capo Caccia, Sardinia, Italy, 2011, 2011

Lecture at ‘Immunobiology seminar series’, Institute of Child Health, UCL, UK, 2008, 2008

Lecture at ‘Immunology seminar series’, Bristol, UK, 2007, 2007

Invited speaker at the XXIIIrd Congress of the European Academy of Allergology and Clinical Immunology, Amsterdam, The Netherlands, 2004, 2004