Dr Swann is a Reader (Associate Professor) in Microbiomics and Human Development within the Division of Integrative Systems Medicine and Digestive Diseases in the Department of Surgery and Cancer. Dr Swann is responsible for leading a metabonomic-based research programme to understand the influence of gene-environment interactions on the mammalian metabolic system and their implications for health and disease. His primary interests fall under two intersecting research themes:
(1) Role of the gut microbiota (the collection of microbes residing in the gastrointestinal tract) in the mammalian metabolic system and their association with host health and disease. This includes their contribution to host endogenous and xenobiotic metabolism, the gut-brain axis and its role in neurological disorders, the carcinogenic potential of the microbiome, and environmental and host factors shaping the acquisition and composition of the gut microbiome.
(2) Impact of early-life events and exposures on mammalian development particularly microbial-host interplay, metabolism, and phenotypic outcomes. A key research area is the application of metabolic phenotyping to the field of global health. Specifically, using a metabonomic approach to characterise the biochemical consequences of undernutrition and infection in children from developing countries to better understand the contributors to the long-term sequelae of early life undernutrition, including impaired cognitive, growth and metabolic functions.
Dr Swann’s research is supported by the Bill and Melinda Gates Foundation, BBSRC, MRC, AstraZeneca, National Institutes of Health (NIH), and the Canadian Institutes of Health Research (CIHR). He is on the editorial board for the journal Microbiome and sits on numerous expert panels relating to the gut microbiota.
Blog article: http://wwwf.imperial.ac.uk/blog/imperial-medicine/2019/05/28/think-small-solving-the-global-challenge-of-malnutrition-by-looking-at-metabolites/
Current lab members:
Gordana Panic (post-doctoral research associate)
Natasa Giallourou (post-doctoral research associate)
Fahmina Fardus-Reid (post-doctoral research associate)
Adesola Bello (PhD student)
Marine Letertre (PhD student)
Yi Yang (PhD student)
Giorgia Caspani (PhD student)
Simone Zuffa (PhD student)
et al., 2021, Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report, Communications Biology, ISSN:2399-3642
et al., 2021, Gut microbial and metabolic profiling reveal the lingering effects of infantile iron deficiency unless treated with iron, Molecular Nutrition and Food Research, Vol:65, ISSN:1613-4125
et al., 2020, Considerations for the design and conduct of human gut microbiota intervention studies relating to foods, European Journal of Nutrition, Vol:59, ISSN:0044-264X, Pages:3347-3368
et al., 2020, Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome (vol 182, pg 1460, 2020), Cell, Vol:183, ISSN:0092-8674, Pages:1137-1140
et al., 2020, Intervention and mechanisms of alanyl-glutamine for inflammation, nutrition, and enteropathy: a randomized controlled trial, Journal of Pediatric Gastroenterology and Nutrition, Vol:71, ISSN:0277-2116, Pages:393-400