Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0728j.swann

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Caspani:2021:10.1038/s42003-021-02421-6,
author = {Caspani, G and Turecki, G and Lam, R and Milev, R and Frey, B and MacQueen, G and Muller, D and Rotzinger, S and Kennedy, S and Foster, J and Swann, J},
doi = {10.1038/s42003-021-02421-6},
journal = {Communications Biology},
title = {Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report},
url = {http://dx.doi.org/10.1038/s42003-021-02421-6},
volume = {4},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - One of the biggest challenges in treating depression is the heterogeneous and qualitative nature of its clinical presentations. This highlights the need to find quantitative molecular markers to tailor existing treatment strategies to the individual’s biological system. In this study, high-resolution metabolic phenotyping of urine and plasma samples from the CAN-BIND study collected before treatment with two common pharmacological strategies, escitalopram and aripiprazole, was performed. Here we show that a panel of LDL and HDL subfractions were negatively correlated with depression in males. For treatment response, lower baseline concentrations of apolipoprotein A1 and HDL were predictive of escitalopram response in males, while higher baseline concentrations of apolipoprotein A2, HDL and VLDL subfractions were predictive of aripiprazole response in females. These findings support the potential of metabolomics in precision medicine and the possibility of identifying personalized interventions for depression.
AU  - Caspani,G
AU  - Turecki,G
AU  - Lam,R
AU  - Milev,R
AU  - Frey,B
AU  - MacQueen,G
AU  - Muller,D
AU  - Rotzinger,S
AU  - Kennedy,S
AU  - Foster,J
AU  - Swann,J
DO  - 10.1038/s42003-021-02421-6
PY  - 2021///
SN  - 2399-3642
TI  - Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-021-02421-6
UR  - http://hdl.handle.net/10044/1/90319
VL  - 4
ER  -
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