The PRECEPT study's aim was to assess maternal cardiovascular changes in established uteroplacental insufficiency. The study recruited women after 24 weeks gestation whose pregnancies were affected by pre-eclampsia and/or fetal growth restriction and women with normal pregnancies and compared their cardiovascular status, namely cardiac output, augmentation index, pulse wave velocity, peripheral vascular resistance and central blood pressure from diagnosis until post-delivery, to characterise changes in relation to time of diagnosis and therapy whilst assessing fetal circulatory changes using Doppler. The metabonomic and cardiovascular biomarker profiles was investigated in relation to maternal cardiovascular function.
Funding for this study was provided by Imperial College NHS Trust and Imperial College Healthcare Charities for Dr Jasmine Tay. The project is a collaboration with the Department of Clinical Pharmacology, Cambridge University.
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