Summary
PRECEPT STUDY
The PRECEPT study's aim was to assess maternal cardiovascular changes in established uteroplacental insufficiency. The study recruited women after 24 weeks gestation whose pregnancies were affected by pre-eclampsia and/or fetal growth restriction and women with normal pregnancies and compared their cardiovascular status, namely cardiac output, augmentation index, pulse wave velocity, peripheral vascular resistance and central blood pressure from diagnosis until post-delivery, to characterise changes in relation to time of diagnosis and therapy whilst assessing fetal circulatory changes using Doppler. The metabonomic and cardiovascular biomarker profiles was investigated in relation to maternal cardiovascular function.
Funding for this study was provided by Imperial College NHS Trust and Imperial College Healthcare Charities for Dr Jasmine Tay. The project is a collaboration with the Department of Clinical Pharmacology, Cambridge University.
Publications
Journals
Masini G, Foo LF, Tay J, et al., 2021, Preeclampsia has 2 phenotypes which require different treatment strategies, American Journal of Obstetrics and Gynecology, ISSN:0002-9378
Masini G, Tay J, McEniery CM, et al., 2020, Maternal cardiovascular dysfunction is associated with hypoxic cerebral and umbilical doppler changes, Journal of Clinical Medicine, Vol:9, ISSN:2077-0383, Pages:1-10
Santhirakumaran S, Tay J, Lees C, 2019, The relationship between maternal characteristics and carotid intima-media thickness using an automated ultrasound technique, Hypertension in Pregnancy, Vol:38, ISSN:1064-1955, Pages:252-259
Tay J, Lees C, 2019, RE: Tay et al, Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function, American Journal of Obstetrics and Gynecology, Vol:221, ISSN:0002-9378, Pages:291-292
Bijl RC, Valensise H, Novelli GP, et al., 2019, Methods and considerations concerning cardiac output measurement in pregnant women: recommendations of the International Working Group on Maternal Hemodynamics, Ultrasound in Obstetrics and Gynecology, Vol:54, ISSN:0960-7692, Pages:35-50