Imperial College London
Alternate

Dr Jasmine Tay

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3313 7316j.tay14

 
 
//

Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tay:2018:10.1016/j.preghy.2018.05.001,
author = {Tay, J and Costanzi, A and Basello, K and Piuri, G and Ferrazzi, E and Speciani, AF and Lees, CC},
doi = {10.1016/j.preghy.2018.05.001},
journal = {Pregnancy Hypertension},
pages = {58--61},
title = {Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies},
url = {http://dx.doi.org/10.1016/j.preghy.2018.05.001},
volume = {13},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesThe objective of this study was the analysis of B-Cell Activating Factor (BAFF) levels in pregnancies affected by PE, and in pregnancies affected by fetal growth restriction without Hypertensive disorders and its possible correlation with pulse wave velocity and cardiac output.Study designProspective study of 69 women at 24–40weeks gestation. Haemodynamic function was assessed in those with Pre-eclampsia (PE, n=19), fetal growth restriction (FGR, n=10) and healthy pregnancies (n=40). Maternal venous BAFF levels at recruitment were measured using ELISA. We analysed the relationship between BAFF and cardiac output (CO), and BAFF and PWV (pulse wave velocity); the gold standard for assessing arterial stiffness. PWV was measured with an oscillometric device and CO using inert gas rebreathing technique. PWV and CO were converted to gestation adjusted indices (z scores).Main outcome measuresThe association between BAFF levels in PE and FGR, and the relationship of BAFF with PWV and CO.ResultsBAFF was higher in PE (p=0.03) but not in FGR (p=0.83) when compared to healthy pregnancies. There was a positive correlation between BAFF levels and z score PWV (r=0.25, p=0.04), but not CO (r=−0.01, p=0.91). BAFF levels did not change with gestational age. (r=0.012, p=0.925).ConclusionsThese findings provide evidence of a possible contribution of BAFF to both maternal inflammation and arterial dysfunction associated with PE. Though no relationship was found with another disorder of placentation: normotensive FGR, this condition is not thought to be associated with maternal inflammation.
AU  - Tay,J
AU  - Costanzi,A
AU  - Basello,K
AU  - Piuri,G
AU  - Ferrazzi,E
AU  - Speciani,AF
AU  - Lees,CC
DO  - 10.1016/j.preghy.2018.05.001
EP  - 61
PY  - 2018///
SN  - 2210-7789
SP  - 58
TI  - Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies
T2  - Pregnancy Hypertension
UR  - http://dx.doi.org/10.1016/j.preghy.2018.05.001
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443326700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68182
VL  - 13
ER  -
Download