Imperial College London
Alternate

Dr Jasmine Tay

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3313 7316j.tay14

 
 
//

Location

 

Queen Charlottes and Chelsea HospitalHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Tay:2019:10.1016/j.ajog.2018.09.017,
author = {Tay, J and Masini, G and McEniery, CM and Giussani, DA and Shaw, CJ and Wilkinson, IB and Bennett, PR and Lees, CC},
doi = {10.1016/j.ajog.2018.09.017},
journal = {American Journal of Obstetrics and Gynecology},
pages = {96.e1--96.e8},
title = {Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function},
url = {http://dx.doi.org/10.1016/j.ajog.2018.09.017},
volume = {220},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe mechanism underlying fetal-placental Doppler index changes in preeclampsia and/or fetal growth restriction are unknown, although both are associated with maternal cardiovascular dysfunction.ObjectiveWe sought to investigate whether there was a relationship between maternal cardiac output and vascular resistance and fetoplacental Doppler findings in healthy and complicated pregnancy.Study DesignWomen with healthy pregnancies (n=62), preeclamptic pregnancies (n=13), preeclamptic pregnancies with fetal growth restriction (n=15), or fetal growth restricted pregnancies (n=17) from 24–40 weeks gestation were included. All of them underwent measurement of cardiac output with the use of an inert gas rebreathing technique and derivation of peripheral vascular resistance. Uterine and fetal Doppler indices were recorded; the latter were z scored to account for gestation. Associations were determined by polynomial regression analyses.ResultsMean uterine artery pulsatility index was higher in fetal growth restriction (1.37; P=.026) and preeclampsia+fetal growth restriction (1.63; P=.001) but not preeclampsia (0.92; P=1) compared with control subjects (0.8). There was a negative relationship between uterine pulsatility index and cardiac output (r2=0.101; P=.025) and umbilical pulsatility index z score and cardiac output (r2=0.078; P=.0015), and there were positive associations between uterine pulsatility index and peripheral vascular resistance (r2=0.150; P=.003) and umbilical pulsatility index z score and peripheral vascular resistance (r2= 0.145; P=.001). There was no significant relationship between cardiac output and peripheral vascular resistance with cerebral Doppler indices.ConclusionUterine artery Doppler change is abnormally elevated in fetal growth restriction with and without preeclampsia, but not in preeclampsia, which may explain the limited sensitivity of uterine artery Doppler changes for all these complications when considered in aggregate. Fur
AU  - Tay,J
AU  - Masini,G
AU  - McEniery,CM
AU  - Giussani,DA
AU  - Shaw,CJ
AU  - Wilkinson,IB
AU  - Bennett,PR
AU  - Lees,CC
DO  - 10.1016/j.ajog.2018.09.017
EP  - 1
PY  - 2019///
SN  - 0002-9378
SP  - 96
TI  - Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function
T2  - American Journal of Obstetrics and Gynecology
UR  - http://dx.doi.org/10.1016/j.ajog.2018.09.017
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454239900022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0002937818307658?via%3Dihub
UR  - http://hdl.handle.net/10044/1/68179
VL  - 220
ER  -
Download