Imperial College London
Alternate

Professor Julian Teare

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 3312 1072j.teare

 
 
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Location

 

CL3 026St Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aldhwayan:2022:10.3390/nu14102141,
author = {Aldhwayan, MM and Al-Najim, W and Ruban, A and Glaysher, MA and Johnson, B and Chhina, N and Dimitriadis, GK and Prechtl, CG and Johnson, NA and Byrne, JP and Goldstone, AP and Teare, JP and Le, Roux CW and Miras, AD},
doi = {10.3390/nu14102141},
journal = {Nutrients},
title = {Does bypass of the proximal small intestine impact food intake, preference, and taste function in humans? An experimental medicine study using the duodenal-jejunal bypass liner},
url = {http://dx.doi.org/10.3390/nu14102141},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences.
AU  - Aldhwayan,MM
AU  - Al-Najim,W
AU  - Ruban,A
AU  - Glaysher,MA
AU  - Johnson,B
AU  - Chhina,N
AU  - Dimitriadis,GK
AU  - Prechtl,CG
AU  - Johnson,NA
AU  - Byrne,JP
AU  - Goldstone,AP
AU  - Teare,JP
AU  - Le,Roux CW
AU  - Miras,AD
DO  - 10.3390/nu14102141
PY  - 2022///
SN  - 2072-6643
TI  - Does bypass of the proximal small intestine impact food intake, preference, and taste function in humans? An experimental medicine study using the duodenal-jejunal bypass liner
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu14102141
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000801953200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/97515
VL  - 14
ER  -
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