Publications
148 results found
Valabhji J, 2023, The journey towards implementation of the NHS Diabetes Prevention Programme: A personal perspective., Diabet Med, Vol: 40
Valabhji J, Barron E, Pratt A, et al., 2023, Prevalence of multiple long-term conditions (multimorbidity) in England: a whole population study of over 60 million people., J R Soc Med
OBJECTIVES: To determine the prevalence of multiple long-term conditions (MLTC) at whole English population level, stratifying by age, sex, socioeconomic status and ethnicity. DESIGN: A whole population study. SETTING: Individuals registered with a general practice in England and alive on 31 March 2020. PARTICIPANTS: 60,004,883 individuals. MAIN OUTCOME MEASURES: MLTC prevalence, defined as two or more of 35 conditions derived from a number of national patient-level datasets. Multivariable logistic regression was used to assess the independent associations of age, sex, ethnicity and deprivation decile with odds of MLTC. RESULTS: The overall prevalence of MLTC was 14.8% (8,878,231), varying from 0.9% (125,159) in those aged 0-19 years to 68.2% (1,905,979) in those aged 80 years and over. In multivariable regression analyses, compared with the 50-59 reference group, the odds ratio was 0.04 (95% confidence interval (CI): 0.04-0.04; p < 0.001) for those aged 0-19 years and 10.21 (10.18-10.24; p < 0.001) for those aged 80 years and over. Odds were higher for men compared with women, 1.02 (1.02-1.02; p < 0.001), for the most deprived decile compared with the least deprived, 2.26 (2.25-2.27; p < 0.001), and for Asian ethnicity compared with those of white ethnicity, 1.05 (1.04-1.05; p < 0.001). Odds were lower for black, mixed and other ethnicities (0.94 (0.94-0.95) p < 0.001, 0.87 (0.87-0.88) p < 0.001 and 0.57 (0.56-0.57) p < 0.001, respectively). MLTC for persons aged 0-19 years were dominated by asthma, autism and epilepsy, for persons aged 20-49 years by depression and asthma, for persons aged 50-59 years by hypertension and depression and for those aged 60 years and older, by cardiometabolic factors and osteoarthritis. There were large numbers of combinations of conditions in each age group ranging from 5936 in those aged 0-19 years
Barron E, Khunti K, Wright AK, et al., 2023, Impact of the COVID-19 pandemic on new diagnoses of type 2 diabetes in England, DIABETES OBESITY & METABOLISM, ISSN: 1462-8902
Lai HTM, Chang K, Sharabiani MTA, et al., 2023, Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study, European Journal of Epidemiology, Vol: 38, Pages: 733-744, ISSN: 0393-2990
To assess 20-year retrospective trajectories of cardio-metabolic factors preceding dementia diagnosis among people with type 2 diabetes (T2D). We identified 227,145 people with T2D aged > 42 years between 1999 and 2018. Annual mean levels of eight routinely measured cardio-metabolic factors were extracted from the Clinical Practice Research Datalink. Multivariable multilevel piecewise and non-piecewise growth curve models assessed retrospective trajectories of cardio-metabolic factors by dementia status from up to 19 years preceding dementia diagnosis (dementia) or last contact with healthcare (no dementia). 23,546 patients developed dementia; mean (SD) follow-up was 10.0 (5.8) years. In the dementia group, mean systolic blood pressure increased 16-19 years before dementia diagnosis compared with patients without dementia, but declined more steeply from 16 years before diagnosis, while diastolic blood pressure generally declined at similar rates. Mean body mass index followed a steeper non-linear decline from 11 years before diagnosis in the dementia group. Mean blood lipid levels (total cholesterol, LDL, HDL) and glycaemic measures (fasting plasma glucose and HbA1c) were generally higher in the dementia group compared with those without dementia and followed similar patterns of change. However, absolute group differences were small. Differences in levels of cardio-metabolic factors were observed up to two decades prior to dementia diagnosis. Our findings suggest that a long follow-up is crucial to minimise reverse causation arising from changes in cardio-metabolic factors during preclinical dementia. Future investigations which address associations between cardiometabolic factors and dementia should account for potential non-linear relationships and consider the timeframe when measurements are taken.
Koutoukidis DA, Barron E, Stevens R, et al., 2023, Association between the month of starting a weight management program and weight change in people at high risk of type 2 diabetes: A prospective cohort study, OBESITY, Vol: 31, Pages: 1707-1716, ISSN: 1930-7381
Barron E, Bradley D, Safazadeh S, et al., 2023, Effectiveness of digital and remote provision of the Healthier You: NHS Diabetes Prevention Programme during the COVID-19 pandemic, DIABETIC MEDICINE, Vol: 40, ISSN: 0742-3071
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- Citations: 3
Holman N, Barron E, Young B, et al., 2023, Comparative Incidence of Diabetes Following Hospital Admission for COVID-19 and Pneumonia: A Cohort Study, DIABETES CARE, Vol: 46, Pages: 938-943, ISSN: 0149-5992
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- Citations: 6
Valabhji J, Kar P, 2023, Rise in type 2 diabetes shows that prevention is more important than ever, BMJ-BRITISH MEDICAL JOURNAL, Vol: 381, ISSN: 0959-535X
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- Citations: 1
Chan J, Blane D, Choudhary P, et al., 2023, Addressing health inequalities in diabetes through research: Recommendations from Diabetes UK's 2022 health inequalities in diabetes workshop, DIABETIC MEDICINE, Vol: 40, ISSN: 0742-3071
Marsden AM, Hann M, Barron E, et al., 2023, Comparison of weight change between face-to-face and digital delivery of the English National Health service diabetes prevention programme: An exploratory non-inferiority study with imputation of plausible weight outcomes, PREVENTIVE MEDICINE REPORTS, Vol: 32
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- Citations: 4
Gharibzadeh S, Razieh C, Davies M, et al., 2023, Physical effects of Covid-19 in patients with diabetes 1 year after hospitalisation in the UK: PHOSP- Covid study, Publisher: WILEY, ISSN: 0742-3071
Bakhai C, Barron E, Gorton T, et al., 2023, Early outcomes from the NHS low calorie diet programme for people with type 2 diabetes, Publisher: WILEY, ISSN: 0742-3071
Holman N, Khunti K, Wild SH, et al., 2023, Care processes in people in remission from type 2 diabetes: A cohort study using the National Diabetes Audit, DIABETIC MEDICINE, Vol: 40, ISSN: 0742-3071
Khunti K, Valabhji J, Misra S, 2023, Diabetes and the COVID-19 pandemic, DIABETOLOGIA, Vol: 66, Pages: 255-266, ISSN: 0012-186X
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- Citations: 16
Misra S, Holman N, Barron E, et al., 2023, Characteristics and care of young people with type 2 diabetes included in the national diabetes audit datasets for England, DIABETIC MEDICINE, Vol: 40, ISSN: 0742-3071
Khunti K, Aroda VR, Aschner P, et al., 2022, The impact of the COVID-19 pandemic on diabetes services: planning for a global recovery, LANCET DIABETES & ENDOCRINOLOGY, Vol: 10, Pages: 890-900, ISSN: 2213-8587
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- Citations: 9
Misra S, Gable D, Khunti K, et al., 2022, Developing services to support the delivery of care to people with early-onset type 2 diabetes, DIABETIC MEDICINE, Vol: 39, ISSN: 0742-3071
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- Citations: 1
Vamos EP, Lai H, Sharabiani M, et al., 2022, Cardio-metabolic factors and risk of dementia in people with type 2 diabetes in England: a large retrospective cohort study, DUK, Publisher: SPRINGER, Pages: S402-S403, ISSN: 0012-186X
Valabhji J, Barron E, Gorton T, et al., 2022, Associations between reductions in routine care delivery and non-COVID-19-related mortality in people with diabetes in England during the COVID-19 pandemic: a population-based parallel cohort study, LANCET DIABETES & ENDOCRINOLOGY, Vol: 10, Pages: 561-570, ISSN: 2213-8587
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- Citations: 9
Lai H, Sharma A, Chang K, et al., 2022, COMPARISON OF SEX-SPECIFIC HISTORICAL CARDIOMETABOLIC TRAJECTORIES IN T2D PATIENTS BY DEMENTIA STATUS IN ENGLAND, DUK, Publisher: BMJ PUBLISHING GROUP, Pages: A1-A2, ISSN: 0143-005X
Evans RA, Leavy OC, Richardson M, et al., 2022, Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study, The Lancet Respiratory Medicine, Vol: 10, Pages: 761-775, ISSN: 2213-2600
BackgroundNo effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge.MethodsThe Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing.Findings2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obes
Holman N, Wild SH, Khunti K, et al., 2022, Incidence and Characteristics of Remission of Type 2 Diabetes in England: A Cohort Study Using the National Diabetes Audit, DIABETES CARE, Vol: 45, Pages: 1151-1161, ISSN: 0149-5992
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- Citations: 7
Ross JAD, Barron E, McGough B, et al., 2022, Uptake and impact of the English National Health Service digital diabetes prevention programme: observational study, BMJ OPEN DIABETES RESEARCH & CARE, Vol: 10
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- Citations: 10
Anjana RM, Oliver N, Nitika S, et al., 2022, USING MHEALTH APPS FOR BEHAVIOUR CHANGE IN URBAN AND RURAL INDIA -A PILOT STUDY, Publisher: MARY ANN LIEBERT, INC, Pages: A187-A187, ISSN: 1520-9156
Ranjani H, Avari P, Nitika S, et al., 2022, ACCEPTABILITY OF TWO NOVEL MHEALTH APPLICATIONS FOR DIABETES PREVENTION IN URBAN AND RURAL INDIA, Publisher: MARY ANN LIEBERT, INC, Pages: A186-A187, ISSN: 1520-9156
Ranjani H, Anjana RM, Valabhji J, et al., 2022, USING MHEALTH FOR TYPE 2 DIABETES RISK REDUCTION IN URBAN AND RURAL INDIA - A PILOT STUDY, Publisher: MARY ANN LIEBERT, INC, Pages: A186-A186, ISSN: 1520-9156
Sharma A, Lai H, Chang K, et al., 2022, A 20-year follow-up of cardiometabolic trajectories amongst individuals with type 2 diabetes before dementia diagnosis by ethnic group, DUK, Publisher: WILEY, ISSN: 0742-3071
Bakhai C, Gorton T, Barron E, et al., 2022, Early outcomes from the NHS Low Calorie Diet programme pilot, Publisher: WILEY, ISSN: 0742-3071
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- Citations: 1
Holman N, Wild SH, Gregg EW, et al., 2022, Comparison of mortality in people with type 1 and type 2 diabetes by age of diagnosis: an incident population-based study in England and Wales, LANCET DIABETES & ENDOCRINOLOGY, Vol: 10, Pages: 95-+, ISSN: 2213-8587
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- Citations: 6
Pearson-Stuttard J, Cheng Y, Bennett J, et al., 2022, Trends in leading causes of hospitalisation among adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records, The Lancet Diabetes and Endocrinology, Vol: 10, Pages: 46-57, ISSN: 2213-8595
BackgroundDiabetes mellitus (DM) leads to a wide range of established vascular and metabolic complications which has resulted in specific prevention programmes being implemented across high-income countries. DM has been associated with increased risk of a broader set of conditions including cancers, liver disease and common infections. We aimed to examine the trends in a broad set of cause-specific hospitalisations in individuals with DM in England from 2003-2018.MethodsWe identified 309,874 individuals with DM in the Clinical Practice Research Datalink, a well described primary care database, linked to Hospital Episode Statistics inpatient data from 2003-2018. We generated a mixed prevalence and incident DM study population through serial cross sections and follow-up over time. We used a discretised Poisson regression model to estimate annual cause-specific hospitalisation rates in men and women with DM across 17 cause groupings. We generated a 1:1 age and sex matched non-DM population to compare findings. FindingsHospitalisation rates were higher for all causes in persons with DM compared to those without throughout the study period. DM itself and Ischaemic Heart Disease (IHD) were the leading causes of excess hospitalisation in 2003, but by 2018, respiratory conditions, cancers and IHD were the most common causes of excess hospitalisation across men and women. Hospitalisation rates declined in almost all traditional DM complication groupings (IHD, stroke, DM, amputations) whilst generally increasing across broader conditions (cancers, infections, respiratory conditions). These differing trends resulted in a diversification in the cause of hospitalisation, such that the traditional DM complications accounted for more than 50% of hospitalisations in 2003, but only approximately 30% in 2018. In contrast, the portion of hospitalisations that broader conditions accounted for increased including respiratory infections being attributable for 12% of hospitalisations in 2
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