Imperial College London
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DrJulienVermot

Faculty of Engineering, Department of Bioengineering

Reader in Development Bio-mechanochemical Signalling
 
 
 
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Contact

 

+44 (0)20 7594 8820j.vermot Website

 
 
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Location

 

B213EBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ferreira:2018:10.1016/j.celrep.2018.10.069,
author = {Ferreira, RR and Pakula, G and Klaeyle, L and Fukui, H and Vilfan, A and Supatto, W and Vermot, J},
doi = {10.1016/j.celrep.2018.10.069},
journal = {Cell Reports},
pages = {2008--2016.e4},
title = {Chiral Cilia orientation in the left-right organizer},
url = {http://dx.doi.org/10.1016/j.celrep.2018.10.069},
volume = {25},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chirality is a property of asymmetry between an object and its mirror image. Most biomolecules and many cell types are chiral. In the left-right organizer (LRO), cilia-driven flows transfer such chirality to the body scale. However, the existence of cellular chirality within tissues remains unknown. Here, we investigate this question in Kupffer’s vesicle (KV), the zebrafish LRO. Quantitative live imaging reveals that cilia populating the KV display asymmetric orientation between the right and left sides, resulting in a chiral structure, which is different from the chiral cilia rotation. This KV chirality establishment is dynamic and depends on planar cell polarity. While its impact on left-right (LR) symmetry breaking remains unclear, we show that this asymmetry does not depend on the LR signaling pathway or flow. This work identifies a different type of tissue asymmetry and sheds light on chirality genesis in developing tissues.
AU  - Ferreira,RR
AU  - Pakula,G
AU  - Klaeyle,L
AU  - Fukui,H
AU  - Vilfan,A
AU  - Supatto,W
AU  - Vermot,J
DO  - 10.1016/j.celrep.2018.10.069
EP  - 2016
PY  - 2018///
SN  - 2211-1247
SP  - 2008
TI  - Chiral Cilia orientation in the left-right organizer
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2018.10.069
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000450794200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S2211124718316735?via%3Dihub
UR  - http://hdl.handle.net/10044/1/74558
VL  - 25
ER  -
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