Imperial College London
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DrJulienVermot

Faculty of Engineering, Department of Bioengineering

Reader in Development Bio-mechanochemical Signalling
 
 
 
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Contact

 

+44 (0)20 7594 8820j.vermot Website

 
 
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Location

 

B213EBessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Steed:2016:10.1038/ncomms11646,
author = {Steed, E and Faggianelli, N and Roth, S and Ramspacher, C and Concordet, J-P and Vermot, J},
doi = {10.1038/ncomms11646},
journal = {Nature Communications},
title = {klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis},
url = {http://dx.doi.org/10.1038/ncomms11646},
volume = {7},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The heartbeat and blood flow signal to endocardial cell progenitors through mechanosensitive proteins that modulate the genetic program controlling heart valve morphogenesis. To date, the mechanism by which mechanical forces coordinate tissue morphogenesis is poorly understood. Here we use high-resolution imaging to uncover the coordinated cell behaviours leading to heart valve formation. We find that heart valves originate from progenitors located in the ventricle and atrium that generate the valve leaflets through a coordinated set of endocardial tissue movements. Gene profiling analyses and live imaging reveal that this reorganization is dependent on extracellular matrix proteins, in particular on the expression of fibronectin1b. We show that blood flow and klf2a, a major endocardial flow-responsive gene, control these cell behaviours and fibronectin1b synthesis. Our results uncover a unique multicellular layering process leading to leaflet formation and demonstrate that endocardial mechanotransduction and valve morphogenesis are coupled via cellular rearrangements mediated by fibronectin synthesis.
AU  - Steed,E
AU  - Faggianelli,N
AU  - Roth,S
AU  - Ramspacher,C
AU  - Concordet,J-P
AU  - Vermot,J
DO  - 10.1038/ncomms11646
PY  - 2016///
SN  - 2041-1723
TI  - klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms11646
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000376667900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 7
ER  -
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