Publications
67 results found
Murray JW, Rudiño-Piñera E, Owen RL, et al., 2005, Parameters affecting the X-ray dose absorbed by macromolecular crystals, JOURNAL OF SYNCHROTRON RADIATION, Vol: 12, Pages: 268-275, ISSN: 0909-0495
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- Citations: 68
Southworth-Davies RJ, Murray JW, Owen R, et al., 2005, The Effects of Temperature and Radiation on Holo and Apo Ferritin Crystals, Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C228-C229, ISSN: 2053-2733
Murray JW, Garman EF, Ravelli RBG, 2004, X-ray absorption by macromolecular crystals: the effects of wavelength and crystal composition on absorbed dose, JOURNAL OF APPLIED CRYSTALLOGRAPHY, Vol: 37, Pages: 513-522, ISSN: 0021-8898
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- Citations: 171
Garman E, Murray JW, 2003, Heavy-atom derivatization, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Vol: 59, Pages: 1903-1913, ISSN: 2059-7983
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- Citations: 49
Murray J, Garman E, 2002, Investigation of possible free-radical scavengers and metrics for radiation damage in protein cryocrystallography, JOURNAL OF SYNCHROTRON RADIATION, Vol: 9, Pages: 347-354, ISSN: 0909-0495
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- Citations: 107
Nieduszynski CA, Murray J, Carrington M, 2002, Whole-genome analysis of animal A- and B-type cyclins, Genome Biology, Vol: 3, Pages: research0070.1-research0070.8.
BACKGROUND: Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene. Complete sequencing of several animal genomes has allowed us to determine the size of the mitotic cyclin gene family and therefore to start to address this issue. RESULTS: We analyzed the Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens genomes to identify known and novel A- and B-type cyclin genes and distinguish them from related pseudogenes. We find only a single functional A-type cyclin gene in invertebrates but two in vertebrates. In addition to the single functional cyclin A gene, the C. elegans genome contains numerous cyclin A pseudogenes. In contrast, the number and relationship of B-type cyclins varies considerably between organisms but all contain at least one cyclin B1-like gene and a cyclin B3 gene. CONCLUSIONS: There are three conserved families of mitotic cyclins in animals: A-, B3- and B-type. The precise number of genes within the A- and B-type families varies in different organisms, possibly as an adaptation to their distinct developmental strategies.
Murray JW, Garman EF, 2002, INVESTIGATION OF POSSIBLE FREE RADICAL SCAVENGERS IN PROTEIN CRYOCRYSTALLOGRAPHY, Publisher: INT UNION CRYSTALLOGRAPHY, Pages: C279-C279, ISSN: 2053-2733
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