Publications
274 results found
Pchejetski D, Nunes J, Sauer L, et al., 2010, Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer, BREAST CANCER RESEARCH AND TREATMENT, Vol: 124, Pages: 543-549, ISSN: 0167-6806
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- Citations: 6
Kirkdale R, Krell J, Brown CO, et al., 2010, The cost of a QALY, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 103, Pages: 715-720, ISSN: 1460-2725
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- Citations: 25
Sauer L, Pshezhetskiy D, Waxman J, 2010, INCREASED EXPRESSION OF SPHINGOSINE KINASE 1 MEDIATES PROSAPOSIN-INDUCED CYTOKINE PRODUCTION, 8th International Meeting of the Sphingolipid-Club, Publisher: SPRINGER, Pages: 10-10, ISSN: 0028-1298
Henry NL, Pchejetski D, A'Hern R, et al., 2010, Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study, BRITISH JOURNAL OF CANCER, Vol: 103, Pages: 291-296, ISSN: 0007-0920
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- Citations: 29
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, ONCOLOGY REPORTS, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
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- Citations: 16
Waxman J, 2010, Commentary on the paper entitled 'ICU and 6-month outcome of oncology patients in the intensive care unit.' 'How Oncology got Better', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 103, Pages: 435-435, ISSN: 1460-2725
Uysal-Onganer P, Kawano Y, Caro M, et al., 2010, Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells, MOLECULAR CANCER, Vol: 9
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- Citations: 118
Curtis AE, Murphy KG, Chaudhri OB, et al., 2010, Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer, Oncology Reports, Vol: 23, Pages: 1729-1734, ISSN: 1021-335X
Kisspeptin, the product of the KiSS-1 gene, inhibits metastasis and stimulates the hypothalamo-pituitary-gonadal axis. Kisspeptin is therefore a putative target in the treatment of hormone-sensitive malignancies. Prostatic carcinoma remains a significant cause of mortality despite improvements in therapy. The role of kisspeptin in prostatic carcinoma remains undefined. We therefore aimed to investigate release of kisspeptin by prostatic cancer cell lines; investigate expression of KiSS-1 in human prostate tissue; investigate whether patients with prostate carcinoma have elevated plasma kisspeptin. 1) Culture medium from prostatic carcinoma cell lines LNCaP, DU145 and PC3 was assayed for kisspeptin immunoreactivity (-IR). Kisspeptin-IR release was detectable from all three cell lines. The effect of hydroxy-flutamide, gefitinib and resveratrol on kisspeptin-IR release from these cell lines was also investigated. No effect of the drugs tested on release of kisspeptin-IR was observed. 2) Expression of KiSS-1 in human prostate tissue (n=4) was investigated using in situ hybridisation. Expression of KiSS-1 was detected in human prostate tissue. 3) Plasma kisspeptin-IR was compared in 92 patients with prostatic carcinoma and 73 male controls. Kisspeptin-IR was not detected in the plasma of either patients with prostate cancer or control patients. We have therefore shown for the first time the release of kisspeptin-IR by prostatic carcinoma cell lines. We have also shown that KiSS-1 is expressed in human prostate tissue, and that circulating levels of kisspeptin-IR are not elevated in patients with prostatic carcinoma. Further work is required to determine the role of kisspeptin in the prostate.
Nunes J, Sauer I, Turner J, et al., 2010, Macrophage-mediated breast cancer cell chemotaxis: the role of sphingosine kinase-1 activation, Conference on Breast Cancer Research, Publisher: BIOMED CENTRAL LTD, Pages: S6-S6, ISSN: 1465-5411
Sauer L, Nunes J, Salunkhe V, et al., 2009, Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel, INTERNATIONAL JOURNAL OF CANCER, Vol: 125, Pages: 2728-2736, ISSN: 0020-7136
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- Citations: 47
Dart DA, Spencer-Dene B, Gamble SC, et al., 2009, Manipulating prohibitin levels provides evidence for an <i>in vivo</i> role in androgen regulation of prostate tumours, ENDOCRINE-RELATED CANCER, Vol: 16, Pages: 1157-1169, ISSN: 1351-0088
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- Citations: 43
Newsom-Davis TE, Kenny LM, Ngan S, et al., 2009, The promiscuous receptor, BJU INTERNATIONAL, Vol: 104, Pages: 1204-1207, ISSN: 1464-4096
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- Citations: 5
Castellano L, Giamas G, Jacob J, et al., 2009, The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 15732-15737, ISSN: 0027-8424
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- Citations: 282
Pshezhetskiy D, Sauer L, Nunes J, et al., 2009, Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate and breast cancer cells to docetaxel, 15th Congress of the European-Cancer-Organization/34th Multidisciplinary Congress of the European-Society-for-Medical-Oncology, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 107-107, ISSN: 1359-6349
Ngan S, Stronach EA, Photiou A, et al., 2009, Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells, ONCOGENE, Vol: 28, Pages: 2051-2063, ISSN: 0950-9232
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- Citations: 54
Castellano L, Giamas G, Jacob J, et al., 2009, Genome wide screen of estrogen receptor -\#945; regulated microRNAs reveals a negative autoregulatory feedback loop, CANCER RESEARCH, Vol: 69, ISSN: 0008-5472
Newsom-Davis T, Kenny L, Al-Shakarchi I, et al., 2009, Voodoo dolls and the cancer patient: patients do trust their doctors, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 102, Pages: 311-319, ISSN: 1460-2725
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- Citations: 8
Kawano Y, Diez S, Uysal-Onganer P, et al., 2009, Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer, BRITISH JOURNAL OF CANCER, Vol: 100, Pages: 1165-1174, ISSN: 0007-0920
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- Citations: 38
Kogianni G, Walker MM, Waxman J, et al., 2009, Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression, EUROPEAN JOURNAL OF CANCER, Vol: 45, Pages: 685-693, ISSN: 0959-8049
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- Citations: 33
King JW, Thomas S, Corsi F, et al., 2009, IL15 Can Reverse the Unresponsiveness of Wilms' Tumor Antigen-Specific CTL in Patients with Prostate Cancer, CLINICAL CANCER RESEARCH, Vol: 15, Pages: 1145-1154, ISSN: 1078-0432
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- Citations: 16
Waxman J, 2009, Japes and jackanapes: on being a junior hospital doctor in the 1970s, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 70, Pages: M29-M29, ISSN: 1750-8460
Henry NL, Charles P, Pshezhetskiy D, et al., 2009, A distinct inflammatory marker pattern in patients with aromatase inhibitor (AI)-induced musculoskeletal symptoms, 31st Annual San Antonio Breast Cancer Symposium, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 144S-145S, ISSN: 0008-5472
Waxman J, 2009, Top-up fees are not the solution, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 70, Pages: 52-52, ISSN: 1750-8460
Waxman J, 2008, Access to cancer drugs: local autonomy or local tyranny?, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 69, Pages: 537-537, ISSN: 1750-8460
Mazhar D, Waxman J, 2008, Early chemotherapy in prostate cancer, NATURE CLINICAL PRACTICE UROLOGY, Vol: 5, Pages: 486-493, ISSN: 1743-4270
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- Citations: 15
King J, Waxman J, Stauss H, 2008, Advances in tumour immunotherapy, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 101, Pages: 675-683, ISSN: 1460-2725
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- Citations: 17
Waxman J, 2008, Access to cancer drugs: local autonomy or local tyranny?, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 69, Pages: 436-437, ISSN: 1750-8460
Kogianni G, Walker MM, Waxman J, et al., 2008, Endo180 expression by tumour cells with an invasive phenotype correlates with prostate cancer progression, European Journal of Cancer Supplements, 20th Meeting of the European Association for Cancer Research, Publisher: Elsevier Ltd, Pages: 79-79
Castellano L, Waxman J, Giamas G, et al., 2008, The identification of new tumour suppressor micromas epigenetically silenced in drug resistant cancer cells, 20th Meeting of the European-Association-for-Cancer-Research, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 95-95, ISSN: 1359-6349
Pchejetski D, Doumerc N, Golzio M, et al., 2008, Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models, MOLECULAR CANCER THERAPEUTICS, Vol: 7, Pages: 1836-1845, ISSN: 1535-7163
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- Citations: 93
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