Publications
274 results found
Pike J, Holmes D, Kamalati T, et al., 2004, Silencing of androgen-regulated genes using a fusion of AR with the PLZF transcriptional repressor, ONCOGENE, Vol: 23, Pages: 7561-7570, ISSN: 0950-9232
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- Citations: 10
Michalaki V, Syrigos K, Odontiadis M, et al., 2004, The prognostic significance of serum levels of tumour necrosis factor- alpha and interleukin-6 and their association with cachexia in patients with prostate cancer., J Clin Oncol, Vol: 22
4743 Background: The complex syndrome of cancer cachexia is multifactorial in origin and several cytokines may be involved in its aetiology. The present study was undertaken to evaluate the relationship between serum tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and cachexia in patients with prostate cancer (CaP), and their prognostic significance. METHODS: The levels of TNF-α and IL-6 were determined in serum samples from 26 patients with organ-confined CaP, from 54 patients with advanced or metastatic CaP and from 38 controls. High sensitive commercially available (ELISA) assays were used to determine cytokine levels. Serum IL-6 and TNF-α levels were correlated with serum albumin levels, hemoglobin levels, body mass index, clinicopathological variables and patient survival. The prognostic significance of the above parameters was assessed using univariate and multivariate Cox's proportional hazards model analyses. RESULTS: Weight loss more than 10% over a 3-6 month period was seen in 7 of 54 patients (13%) with advanced CaP. The median levels of TNF-α and IL-6 were significantly elevated in cachectic patients with advanced prostate cancer (9.3 pg/ml and 6.7 pg/ml respectively) compared with patients with localized disease (1.3 pg/ml, and 1.9 pg/ml p< .001), or healthy subjects. The serum albumin levels, hemoglobin levels, and body mass index of the patients with elevated serum TNF-α and IL-6 levels were significantly lower (p< 0.001) than the corresponding values in patients with very low levels of both cytokines. TNF-α levels correlated with IL-6 levels, but there was no correlation between PSA levels and cytokine levels. With a median follow-up of 48 months, patients with elevated serum levels of both cytokines and cachexia had a significantly higher mortality rate (p < 0.05) than those with undetectable serum levels. CONCLUSIONS: These results suggest that TNF-α and IL-6 levels were correlated with
Michalaki V, Syrigos K, Odontiadis M, et al., 2004, The prognostic significance of serum levels of tumour necrosis factor-alpha and interleukin-6 and their association with cachexia in patients with prostate cancer, 40th Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 442S-442S, ISSN: 0732-183X
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- Citations: 1
Michalaki V, Syrigos K, Charles P, et al., 2004, Serum levels of IL-6 and TNF-α correlate with clinicopathological features and patient survival in patients with prostate cancer, BRITISH JOURNAL OF CANCER, Vol: 90, Pages: 2312-2316, ISSN: 0007-0920
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- Citations: 305
Gamble SC, Odontiadis M, Waxman J, et al., 2004, Androgens target prohibitin to regulate proliferation of prostate cancer cells, ONCOGENE, Vol: 23, Pages: 2996-3004, ISSN: 0950-9232
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- Citations: 85
Giannini A, Mazor M, Orme M, et al., 2004, Nuclear export of α-catenin:: overlap between nuclear export signal sequences and the β-catenin binding site, EXPERIMENTAL CELL RESEARCH, Vol: 295, Pages: 150-160, ISSN: 0014-4827
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- Citations: 19
Islam TA, Patel A, Kaisary AV, et al., 2004, In vitro deregulation of markers characteristic of human prostate epithelial cells, TISSUE & CELL, Vol: 36, Pages: 107-113, ISSN: 0040-8166
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- Citations: 1
Mazhar D, Waxman J, 2004, Gene therapy for prostate cancer, BJU INTERNATIONAL, Vol: 93, Pages: 465-469, ISSN: 1464-4096
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- Citations: 6
Powell SM, Christiaens V, Voulgaraki D, et al., 2004, Mechanisms of androgen receptor signalling via steroid receptor coactivator-1 in prostate, ENDOCRINE-RELATED CANCER, Vol: 11, Pages: 117-130, ISSN: 1351-0088
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- Citations: 62
Michalaki V, Charles P, Syrigos K, et al., 2004, Serial serum measurements of Interleukin-6 (IL-6), and Tumor Necrosis Factor-alpha (TNF-α) correlate with disease progression in patients with prostate cancer, ANNALS OF ONCOLOGY, Vol: 15, Pages: 113-113, ISSN: 0923-7534
Mazhar D, Waxman J, 2004, Diet and prostate cancer, BJU INTERNATIONAL, Vol: 93, Pages: 919-922, ISSN: 1464-4096
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- Citations: 7
Manisty C, Waxman J, 2003, For and against - Doctors should not discuss resuscitation with terminally ill patients - For, BRITISH MEDICAL JOURNAL, Vol: 327, Pages: 614-615, ISSN: 0959-535X
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- Citations: 20
Dhillon T, Waxman J, 2003, Osteoporosis and prostate cancer, BRITISH JOURNAL OF CANCER, Vol: 89, Pages: 779-780, ISSN: 0007-0920
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- Citations: 3
Mazhar D, Ali S, Buluwela L, et al., 2003, Gene ice as applied to studies of hormonally-responsive cancers, British Cancer Research Meeting 2003, Publisher: NATURE PUBLISHING GROUP, Pages: S4-S4, ISSN: 0007-0920
Syrigos KN, Harrington KJ, Karayiannakis AJ, et al., 2003, Clinical significance of heat shock protein-70 expression in bladder cancer, UROLOGY, Vol: 61, Pages: 677-680, ISSN: 0090-4295
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- Citations: 56
Waxman J, Mazhar D, 2003, How are we looking after prostate cancer?, QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, Vol: 96, Pages: 75-79, ISSN: 1460-2725
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- Citations: 4
Mazhar D, Waxman J, 2002, Prostate cancer, POSTGRADUATE MEDICAL JOURNAL, Vol: 78, Pages: 590-595, ISSN: 0032-5473
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- Citations: 17
Wang Q, Holmes DIR, Powell SM, et al., 2002, Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene, CANCER LETTERS, Vol: 175, Pages: 63-69, ISSN: 0304-3835
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- Citations: 52
Agarwal R, Waxman J, 2002, Hormone therapy of prostate cancer, Treatment options in urological cancer, Pages: 220-236, ISBN: 9780632055890
Agarwal R, Waxman J, 2002, The Endocrinology of Malignancy, Treatment of Cancer, Pages: 143-151, ISBN: 9780340759646
Nicholson S, Waxman J, 2002, Clues from Hypercalcaemia, Br J Cancer, Vol: 86, Pages: 1021-1022, ISSN: 0007-0920
Agarwal R, Waxman J, 2002, Prostate, Treatment of Cancer 4th Edition, Pages: 633-645, ISBN: 9780340759646
Wang J, Waxman J, 2002, The molecular biology of prostate cancer, Treatment Options in Urological Cancer, Pages: 141-159, ISBN: 9780632055890
Horwich A, Waxman J, Abel P, et al., 2002, Tumours of the prostate, Oxford textbook of oncology 2nd edition, Pages: 1939-1972, ISBN: 9780192629265
Wang J, Waxman J, 2001, Chemotherapy for prostate cancer, CLINICAL ONCOLOGY, Vol: 13, Pages: 453-454, ISSN: 0936-6555
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- Citations: 2
Wang J, Halford S, Rigg A, et al., 2000, Adjuvant mitozantrone chemotherapy in advanced prostate cancer, BJU INTERNATIONAL, Vol: 86, Pages: 675-680, ISSN: 1464-4096
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- Citations: 72
Syrigos KN, Deonarain DM, Karayiannakis A, et al., 2000, Epithelial mucin expression in bladder cancer: correlation with pathological and clinical parameters, UROLOGICAL RESEARCH, Vol: 28, Pages: 241-245, ISSN: 0300-5623
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- Citations: 2
Dockery F, Rajkumar C, Agarwal S, et al., 2000, Androgen deprivation in males is associated with decreased central arterial compliance and reduced central systolic blood pressure, JOURNAL OF HUMAN HYPERTENSION, Vol: 14, Pages: 395-397, ISSN: 0950-9240
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- Citations: 19
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