Imperial College London
Alternate

ProfessorJonathanWaxman

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor of Oncology
 
 
 
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Contact

 

j.waxman

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gorroño-Etxebarria:2019:10.3390/cancers11070908,
author = {Gorroño-Etxebarria, I and Aguirre, U and Sanchez, S and González, N and Escobar, A and Zabalza, I and Quintana, JM and Vivanco, MD and Waxman, J and Kypta, RM},
doi = {10.3390/cancers11070908},
journal = {Cancers},
title = {Wnt-11 as a potential prognostic biomarker and therapeutic target in colorectal cancer},
url = {http://dx.doi.org/10.3390/cancers11070908},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The expression of the secreted factor Wnt-11 is elevated in several types of cancer, includingcolorectal cancer, where it promotes cancer cell migration and invasion. Analysis of colorectalcancer gene expression databases associated WNT11 mRNA expression with increased likelihood ofmetastasis in a subset of patients. WNT11 expression was correlated with the expression of the Wntreceptors FZD6, RYK, and PTK7, and the combined expression of WNT11, FZD6 and RYK or PTK7was associated with an increased risk of 5-year mortality rates. Immunohistochemical analysis ofWnt-11 in a cohort of 357 colorectal cancer patients found significantly higher Wnt-11 levels in tumors,compared with benign tissue. Elevated Wnt-11 levels occurred more frequently in rectal tumors thanin colonic tumors and in tumors from women than men. In univariate analysis, increased Wnt-11expression was also associated with tumor invasion and increased 5-year mortality. High Wnt-11levels were not associated with high levels of nuclear β-catenin, suggesting Wnt-11 is not simplyan indicator for activation of β-catenin-dependent signaling. Expression of Wnt-11 in colorectalcancer cell lines expressing low endogenous Wnt-11 inhibited β-catenin/Tcf activity and increasedATF2-dependent transcriptional activity. WNT11 gene silencing and antibody-mediated inhibitionof Wnt-11 in colorectal cancer cell lines expressing high Wnt-11 reduced their capacity for invasion.Together, these observations suggest that Wnt-11 could be a potential target for the treatment ofpatients with invasive colorectal cancer.
AU  - Gorroño-Etxebarria,I
AU  - Aguirre,U
AU  - Sanchez,S
AU  - González,N
AU  - Escobar,A
AU  - Zabalza,I
AU  - Quintana,JM
AU  - Vivanco,MD
AU  - Waxman,J
AU  - Kypta,RM
DO  - 10.3390/cancers11070908
PY  - 2019///
SN  - 2072-6694
TI  - Wnt-11 as a potential prognostic biomarker and therapeutic target in colorectal cancer
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers11070908
UR  - http://hdl.handle.net/10044/1/71704
VL  - 11
ER  -
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