Imperial College London
Alternate

ProfessorJonathanWaxman

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor of Oncology
 
 
 
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Contact

 

j.waxman

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{O'Hanlon:2012:bjr/13017671,
author = {O'Hanlon, Brown C and Waxman, J},
doi = {bjr/13017671},
journal = {Br J Radiol},
pages = {S28--S40},
title = {Current management of prostate cancer: dilemmas and trials.},
url = {http://dx.doi.org/10.1259/bjr/13017671},
volume = {85 Spec No 1},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The past decade has witnessed significant advances in our understanding of the biology of prostate cancer. Androgen ablation/androgen receptor inhibition remains as the mainstay of treatment for advanced prostate cancer. Our understanding of the biology of prostate cancer has increased exponentially owing to advances in molecular biology. With this knowledge many intriguing issues have come to light, which clinicians and scientists alike strive to answer. These include why prostate cancer is so common, what drives the development of prostate cancer at a molecular level, why prostate cancer appears refractory to many families of cytotoxic chemotherapeutics, and why prostate cancer preferentially metastasizes to bone. Two clinical forms of prostate cancer have been identified: indolent organ confined disease, which elderly men often die of, and aggressive metastatic disease. A method of distinguishing between these two forms of the disease at an organ-confined stage remains elusive. Understanding the mechanisms of castrate resistance is a further issue of clinical importance. New trials of treatments, including molecular agents that target prostate cancer from a range of angles, have been instituted over the past 10-15 years. We can look at these trials not only as a chance to investigate the effectiveness of new treatments but also as an opportunity to further understand the complex biology of this disease.
AU  - O'Hanlon,Brown C
AU  - Waxman,J
DO  - bjr/13017671
EP  - 40
PY  - 2012///
SP  - 28
TI  - Current management of prostate cancer: dilemmas and trials.
T2  - Br J Radiol
UR  - http://dx.doi.org/10.1259/bjr/13017671
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23118100
VL  - 85 Spec No 1
ER  -
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