Imperial College London
Alternate

ProfessorWisiaWedzicha

Faculty of Medicine, National Heart & Lung Institute

Consul (clinical) for the Faculty of Medicine
 
 
 
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Contact

 

j.wedzicha

 
 
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Location

 

B142Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Muro:2020:10.1111/resp.13651,
author = {Muro, S and Yoshisue, H and Kostikas, K and Olsson, P and Gupta, P and Wedzicha, JA},
doi = {10.1111/resp.13651},
journal = {Respirology},
pages = {393--400},
title = {Indacaterol/glycopyrronium versus tiotropium or glycopyrronium in long-acting bronchodilator-naïve COPD patients: a pooled analysis},
url = {http://dx.doi.org/10.1111/resp.13651},
volume = {25},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVE: Indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily (q.d.) has demonstrated greater improvements in lung function, patient-reported outcomes and lower exacerbation rates versus mono long-acting muscarinic antagonists (LAMA) in chronic obstructive pulmonary disease (COPD) patients. However, data are limited on initial treatment with IND/GLY 110/50 μg q.d. versus mono LAMA in COPD patients, not previously on maintenance treatment with long-acting bronchodilators (LABD). METHODS: A pooled analysis of ARISE, SHINE and SPARK trials was conducted to evaluate the efficacy of IND/GLY 110/50 μg q.d. versus open-label (OL) tiotropium (TIO) 18 μg q.d. and GLY 50 μg q.d. in COPD patients, not on maintenance treatment with LABD at study entry (LABD-naïve). Efficacy was assessed after 24/26 weeks of treatment. RESULTS: In total, 998 LABD-naïve patients were included (IND/GLY: 353; OL TIO: 328; GLY: 317). Patients treated with IND/GLY 110/50 μg q.d. experienced greater improvements in trough forced expiratory volume in 1 s (FEV1 ) versus OL TIO 18 μg q.d. (least squares mean treatment difference (Δ): 0.086 L) and GLY 50 μg q.d. (Δ: 0.080 L) after 24/26 weeks. Improvements in electronic diary (eDiary) symptom scores, transition dyspnoea index (TDI) focal score, St George's Respiratory Questionnaire (SGRQ) total score and rescue medication use were also greater with IND/GLY versus OL TIO and GLY. Greater proportion of patients achieved minimal clinically important difference in trough FEV1 , TDI and SGRQ with IND/GLY versus OL TIO and GLY. CONCLUSION: LABD-naïve patients treated with IND/GLY 110/50 μg q.d. achieved improvements in lung function, daily symptoms, dyspnoea, health-related quality of life and rescue medication use versus those who received single LAMA.
AU  - Muro,S
AU  - Yoshisue,H
AU  - Kostikas,K
AU  - Olsson,P
AU  - Gupta,P
AU  - Wedzicha,JA
DO  - 10.1111/resp.13651
EP  - 400
PY  - 2020///
SN  - 1323-7799
SP  - 393
TI  - Indacaterol/glycopyrronium versus tiotropium or glycopyrronium in long-acting bronchodilator-naïve COPD patients: a pooled analysis
T2  - Respirology
UR  - http://dx.doi.org/10.1111/resp.13651
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31339215
UR  - http://hdl.handle.net/10044/1/72420
VL  - 25
ER  -
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