Imperial College London

DrJacquesBehmoaras

Faculty of MedicineDepartment of Immunology and Inflammation

Reader in Immunogenetics
 
 
 
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Contact

 

+44 (0)20 3313 2339jacques.behmoaras Website

 
 
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Location

 

9N13Commonwealth BuildingHammersmith Campus

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Summary

 

Summary

 

RESEARCH

I established my research group at Imperial College London in 2010. The group received funding from the Medical Research Council, Wellcome Trust and Kidney Research UK. Our main interest in to understand genetic variation that controls macrophage function in complex inflammatory disorders. We use animal models of inflammatory kidney disease, wound healing/fibrosis, metabolic syndrome, bone inflammation and apply systems-genetics approaches to investigate the effect of germline sequence variation on macrophage plasticity. Our recent approaches pointed towards the importance of targeting macrophage energy metabolism in inflammatory and fibrotic disease.

JB Research Team

 

COLLABORATIONS

Our main external collaborators are Dr Enrico Petretto at Duke-NUS, Singapore (https://www.duke-nus.edu.sg/content/petretto-enrico); Dr Christian Frezza at the MRC Cancer Unit, University of Cambridge (https://www.mrc-cu.cam.ac.uk/research/Christian-frezza-folder).

SELECTED RECENT PUBLICATIONS (2017-2020)

2020    Pereira M, Ko JH, Logan J, Protheroe H, Kim KB, Tan ALM, Park KS, Rotival M, Petretto E, Bassett JHD, Williams GR, and Behmoaras J. A trans-eQTL network regulates osteoclast multinucleation and bone mass. Elife. 2020 Jun 19;9:e55549. doi: 10.7554/eLife.55549.

2019    Pereira M, Chen TD, Buang N, Olona A, Ko JH, Prendecki M, Costa ASH, Nikitopoulou E, Tronci L, Pusey CD, Cook HT, McAdoo SP, Frezza C and Behmoaras J. Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo. Cell Reports. 2019 Jul 9;28(2):498-511.

2019    Bagnati M, Moreno-Moral A, Ko JH, Nicod J, Harmston N, Imprialou M, Game L, Gil J, Petretto E and Behmoaras J. Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing. JCI Insight. 2019 Jan 24;4(2)

2018    Olona A, Terra X, Ko, JH, Grau-Bové C, Pinent M, Ardevol A, Garcia Diaz A, Moreno-Moral A, Edin, M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M and Behmoaras J. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Mol Metab, 2018 May;11:18-32

2018    Moreno-Moral A, Bagnati B, Koturan S, Ko, JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, and Petretto E. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Ann Rheum Dis, 2018 Apr;77(4):596-601.

2017    Papathanassiu A, Ko JH, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C and Behmoaras J. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Nat Commun, 2017 Jul 12;8:16040.



Publications

Journals

Gisby J, Clarke C, Medjeral-Thomas N, et al., 2020, Longitudinal proteomic profiling of high-risk patients with COVID-19 reveals markers of severity and predictors of fatal disease, Medrxiv

Behmoaras J, 2020, BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages, Journal of Cell Science, ISSN:0021-9533

Pereira M, Ko J-H, Logan J, et al., 2020, A trans-eQTL network regulates osteoclast multinucleation and bone mass, Elife, Vol:9, ISSN:2050-084X

Guerrero A, Herranz N, Sun B, et al., 2019, Cardiac glycosides are broad-spectrum senolytics, Nature Metabolism, Vol:1, ISSN:2522-5812, Pages:1074-1088

Pereira M, Chen T-D, Buang N, et al., 2019, Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo, Cell Reports, Vol:28, ISSN:2211-1247, Pages:498-511.e5

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