Publications
74 results found
Atanur SS, Birol I, Guryev V, et al., 2010, The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance, GENOME RESEARCH, Vol: 20, Pages: 791-803, ISSN: 1088-9051
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- Citations: 74
Aitman TJ, Petretto E, Behmoaras J, 2010, Genetic Mapping and Positional Cloning, RAT GENOMICS: METHODS AND PROTOCOLS, Vol: 597, Pages: 13-32, ISSN: 1064-3745
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- Citations: 8
Behmoaras J, Cook HT, Pusey CD, 2009, Kallikreins: unravelling the genetics of autoimmune glomerulonephritis, NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol: 24, Pages: 2987-2989, ISSN: 0931-0509
Behmoaras J, Cook HT, Aitman T, 2009, Treatment of inflammatory diseases, WO 2009053683 A3
Reynolds J, Tadros S, Smith J, et al., 2008, Genetic susceptibility to experimental autoimmune glomerulonephritis in congenic rats, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 36-37, ISSN: 0019-2805
Behmoaras J, Slove S, Seve S, et al., 2008, Differential Expression of Lysyl Oxidases LOXL1 and LOX During Growth and Aging Suggests Specific Roles in Elastin and Collagen Fiber Remodeling in Rat Aorta, REJUVENATION RESEARCH, Vol: 11, Pages: 883-889, ISSN: 1549-1684
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- Citations: 48
Behmoaras J, Bhangal G, Smith J, et al., 2008, <i>Jund</i> is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility, NATURE GENETICS, Vol: 40, Pages: 553-559, ISSN: 1061-4036
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- Citations: 69
Kota L, Osborne-Pellegrin M, Schulz H, et al., 2007, Quantitative genetic basis of arterial phenotypes in the Brown Norway rat, PHYSIOLOGICAL GENOMICS, Vol: 30, Pages: 17-25, ISSN: 1094-8341
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- Citations: 11
Smith J, Lai PC, Behmoaras J, et al., 2007, Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat, J.Am.Soc.Nephrol., Vol: 18, Pages: 1816-1823
The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis. In the model of nephrotoxic nephritis (NTN) that is induced by a small dose of nephrotoxic globulin, WKY rats developed crescents in 80 +/- 2% of glomeruli at day 10, whereas no crescents were seen in Lewis rats. This was associated with marked increase in monocyte chemoattractant protein-1 synthesis in WKY glomeruli. It was posited whether susceptibility depended on circulating cells or intrinsic renal cells. Bone marrow (BM) isografts from WKY to WKY or Lewis to Lewis did not affect susceptibility to NTN. When BM was transferred from WKY to Lewis rats, crescents developed in 35 +/- 9% of glomeruli 10 d after induction of NTN, indicating that susceptibility could be transferred by BM cells. However, crescents were also seen in WKY rats that were given Lewis marrow. For assessment of the contribution of intrinsic renal cells, kidneys from WKY or Lewis rats were transplanted into F1 animals. In NTN, the ratio of crescents in the transplanted kidney to the native kidney was significantly higher for WKY-to-F1 than for Lewis-to-F1 transplants, demonstrating that the kidney itself also influences susceptibility. Mesangial cell responses were then examined in the two strains. Mesangial cells that were derived from WKY rats synthesized significantly more monocyte chemoattractant protein-1 basally and after stimulation with heat-aggregated rabbit IgG or TNF-alpha. These results show that susceptibility to NTN in the WKY rat depends on both circulating and intrinsic renal cells and that there are genetic differences between the strains in mesangial responses to inflammatory stimuli
Gauguier D, Behmoaras J, Argoud K, et al., 2005, Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta, HYPERTENSION, Vol: 45, Pages: 460-466, ISSN: 0194-911X
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- Citations: 16
Behmoaras J, Osborne-Pellegrin M, Gauguier D, et al., 2005, Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 288, Pages: H769-H777, ISSN: 0363-6135
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- Citations: 27
Kota L, Osborne-Pellegrin M, Schulz H, et al., 2004, Mapping of QTLs involved in several arterial and renal phenotypes observed in the Brown Norway rat, 9th Annual Meeting of the European Council for Cardiovascular Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 580-580, ISSN: 0194-911X
Osborne-Pellegrin M, Kota M, Schulz H, et al., 2004, Identification of QTLs involved in several arterial phenotypes observed in the Brown Norway rat, 3rd European Symposium on Elastin, Publisher: ELSEVIER SCIENCE BV, Pages: 408-408, ISSN: 0945-053X
Behmoaras J, Gauguier D, Argoud K, et al., 2004, Chromosomal mapping of quantitative trait loci controlling components of the aortic extracellular matrix in the Brown Norway rat, 3rd European Symposium on Elastin, Publisher: ELSEVIER SCIENCE BV, Pages: 394-395, ISSN: 0945-053X
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