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@article{Behmoaras:2021:10.1111/febs.15682,
author = {Behmoaras, J},
doi = {10.1111/febs.15682},
journal = {The Federation of European Biochemical Societies (FEBS) Journal},
pages = {6972--6989},
title = {The versatile biochemistry of iron in macrophage effector functions},
url = {http://dx.doi.org/10.1111/febs.15682},
volume = {288},
year = {2021}
}

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TY  - JOUR
AB  - Macrophages are mononuclear phagocytes with remarkable polarization ability that allow them to have tissuespecific functions during development, homeostasis, inflammatory and infectious disease. One particular trophic factor in the tissue environment is iron, which is intimately linked to macrophage effector functions. Macrophages have a welldescribed role in the control of systemic iron levels, but their activation state is also depending on ironcontaining proteins/enzymes. Haemoproteins, dioxygenases and iron–sulphur (FeS) enzymes are ironbinding proteins that have bactericidal, metabolic and epigeneticrelated functions, essential to shape the contextdependent macrophage polarization. In this review, I describe mainly proinflammatory macrophage polarization focussing on the role of iron biochemistry in selected haemoproteins and FeS enzymes. I show how iron, as part of haem or FeS clusters, participates in the cellular control of proinflammatory redox reactions in parallel with its role as enzymatic cofactor. I highlight a possible coordinated regulation of haemoproteins and FeS enzymes during classical macrophage activation. Finally, I describe tryptophan and αketoglutarate metabolism as two essential effector pathways in macrophages that use diverse iron biochemistry at different enzymatic steps. Through these pathways, I show how iron participates in the regulation of essential metabolites that shape macrophage function.
AU  - Behmoaras,J
DO  - 10.1111/febs.15682
EP  - 6989
PY  - 2021///
SN  - 1742-464X
SP  - 6972
TI  - The versatile biochemistry of iron in macrophage effector functions
T2  - The Federation of European Biochemical Societies (FEBS) Journal
UR  - http://dx.doi.org/10.1111/febs.15682
UR  - https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15682
UR  - http://hdl.handle.net/10044/1/86360
VL  - 288
ER  -

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