Imperial College London
Alternate

DrJacquesBehmoaras

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunogenetics
 
 
 
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Contact

 

+44 (0)20 3313 2339jacques.behmoaras Website

 
 
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Location

 

9N13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Moreno-Moral:2017:10.1007/978-1-4939-6427-7_16,
author = {Moreno-Moral, A and Pesce, F and Behmoaras, J and Petretto, E},
booktitle = {Systems Genetics. Methods in Molecular Biology},
doi = {10.1007/978-1-4939-6427-7_16},
pages = {337--362},
publisher = {Humana Press},
title = {Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.},
url = {http://dx.doi.org/10.1007/978-1-4939-6427-7_16},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Systems genetics stems from systems biology and similarly employs integrative modeling approaches to describe the perturbations and phenotypic effects observed in a complex system. However, in the case of systems genetics the main source of perturbation is naturally occurring genetic variation, which can be analyzed at the systems-level to explain the observed variation in phenotypic traits. In contrast with conventional single-variant association approaches, the success of systems genetics has been in the identification of gene networks and molecular pathways that underlie complex disease. In addition, systems genetics has proven useful in the discovery of master trans-acting genetic regulators of functional networks and pathways, which in many cases revealed unexpected gene targets for disease. Here we detail the central components of a fully integrated systems genetics approach to complex disease, starting from assessment of genetic and gene expression variation, linking DNA sequence variation to mRNA (expression QTL mapping), gene regulatory network analysis and mapping the genetic control of regulatory networks. By summarizing a few illustrative (and successful) examples, we highlight how different data-modeling strategies can be effectively integrated in a systems genetics study.
AU  - Moreno-Moral,A
AU  - Pesce,F
AU  - Behmoaras,J
AU  - Petretto,E
DO  - 10.1007/978-1-4939-6427-7_16
EP  - 362
PB  - Humana Press
PY  - 2017///
SN  - 978-1-4939-6425-3
SP  - 337
TI  - Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.
T1  - Systems Genetics. Methods in Molecular Biology
UR  - http://dx.doi.org/10.1007/978-1-4939-6427-7_16
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27933533
ER  -
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