Imperial College London

Professor Jake Baum

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Cell Biology and Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 5420jake.baum Website

 
 
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Location

 

609Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Throughout its complex lifecycle the malaria parasites, from the genus Plasmodium, must traverse tissues and invade a diversity of host cells to ensure successful propagation of their lifecycle. Each lifecycle stage is exquisitely designed for cell movement, tissue targeting and host cell invasion, yet we still do not understand the basic mechanics of how the parasite motor produces force and translates this into powerful movement or cell penetration. Unlike all other eukaryotic cells, the malaria parasites rely on an internal actin-myosin motor, linked through to the outside world through secreted surface adhesins across which it literally glides.

Our lab is focused on reconstructing Plasmodium gliding motor function in vitro, its regulation and in a cellular context exploring how the core factors that control motility are distributed. Our work covers the spectrum of scales from single molecule through to whole cell, biochemistry through structural biology and cell biology and, since moving to Imperial, the mysterious world of biophysics.

Ultimately our goal is to break apart Plasmodium motility at every level to generate fundamental understanding into parasite biology and identify potential targets to stop the parasite dead in its tracks!

Publications

Journals

Malpartida-Cardenas K, Miscourides N, Rodriguez-Manzano J, et al., 2019, Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform, Biosensors and Bioelectronics, Vol:145, ISSN:0956-5663

Eden Primary C, Straschil U, Witmer K, et al., A screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials, Archives of Disease in Childhood, ISSN:0003-9888

Del Rosario M, Periz J, Pavlou G, et al., 2019, Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion., Embo Rep

Rueda-Zubiaurre A, Yahiya S, Fischer O, et al., 2019, Structure-activity relationship studies of a novel class of transmission blocking antimalarials targeting male gametes., Journal of Medicinal Chemistry, ISSN:0022-2623

Satchwell TJ, Wright KE, Haydn-Smith KL, et al., 2019, Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements, Nature Communications, Vol:10, ISSN:2041-1723

More Publications