Imperial College London

Professor Jake Baum

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Cell Biology and Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 5420jake.baum Website

 
 
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Location

 

609Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

OVERVIEW

Malaria parasites are obligate intracellular parasites that must invade human cells to complete their development. During the blood stages of parasite infection this is undertaken by the merozoite form of the parasite – one of the smallest known eukaryotic cells – that rapidly enters the human erythrocyte in a process that lasts less than 30 seconds. But how does the parasite get into the human cell? In the last few years, insights into the mechanics of parasite invasion have started to be dissected following improvements in our ability to image the events of invasion, capturing and freezing parasites mid way in. Whilst, this has permitted detailed dissection of the molecular architecture of invading parasites and the localization of core molecular components of the invasion machinery by fixed microscopy, we still know very little about the dynamics of live invasion beyond simple black and white wide-field microscopy.