Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer in Cardiology (Cardiac MR and AI)



james.howard1 Website CV




Block B Hammersmith HospitalHammersmith Campus





Dr James Howard is a Senior Lecturer, BHF Intermediate Fellow and Honorary Consultant Cardiologist at Imperial College.

James' research focuses on using novel computational approaches to solve important problems in heart disease. His main research interest is the application of artificial intelligence (AI) to deliver individualised and efficient cardiac MRI scanning. However, he has experience in running clinical trials and applying AI in a variety of fields, including ultrasound scans, ECGs and X-rays.

His clinical and academic training has been supported by several prestigious fellowships, including an NIHR Academic Clinical Fellowship, a Wellcome Trust Clinical Research Training Fellowship, an NIHR Clinical Lectureship, and most recently a BHF Intermediate Clinical Research Fellowship. He has secured over £1 million of research funding.

He was recently awarded his PhD, “Deep Learning Using Convolutional Neural Networks in Clinical Cardiology”. He has published extensively in the field of cardiovascular medicine, particularly artificial intelligence (AI) and he was recently awarded a $40,000 prize by Facebook, Microsoft and Amazon for his work on detecting 'fake news' using AI. 

James read Clinical Medicine at Trinity College, the University of Cambridge, where he also undertook his BA in Natural Sciences. Alongside his medical training he has undertaken postgraduate qualifications in Clinical Trials from the London School of Hygiene and Tropical Medicine, and in Medical Education from the University of Cardiff. 

Why are statin side effects so common? Using smartphones to solve the mystery

James was joint first author on the SAMSON trial, published in the New England Journal of Medicine. This novel "N-of-1" trial used smartphones to assess daily symptoms in patients who were previously unable to take statins, and showed that 90% of the symptom burden our patients suffer from taking statins is also present when they take placebo. The trial received widespread international interest (BBC; Daily Mail).

SAMSON study results

Artificial intelligence in cardiac imaging

James has published numerous papers which demonstrate the ability of artificial intelligence to solve problems in clinical cardiology. His research tends to focus on the use of convolutional neural networks. He emphasises the importance of these solutions making it from "bench-to-bedside", a common problem in AI research where systems are reported to have excellent performance, but never enter clinical practice. 2 of his artificial intelligence solutions for MRI scans are available for use at Hammersmith Hospital, and another on pacemaker identification is free to use through any web browser.

Automated cardiac MRI chamber quantification - LINK

James investigated whether deep learning of the sequences acquired in the first minutes of a scan could provide an early alert of abnormal features. It does this by segmenting out slices of the heart acquired at the start of a scan, and using these to reconstruct an accurate 3D model of the patient's heart. This solution is now in clinical use on the MRI scanners at Hammersmith Hospital.

Automated MRI analysis

Pacemaker identification using neural networks - LINK

It's common for doctors to need to identify what model of pacemaker patients have during emergencies. James developed a free-to-use tool using AI which is able to accurately identify the model of pacemaker present on a chest X-ray, with far greater accuracy than that of a cardiologist.Pacemaker AI

Cardiac pressure waveforms - LINK

The identification of adverse pressure signals during an angiogram, termed "damping", is necessary to maintain safety and the accuracy of coronary physiology measurements. James developed an AI which is able to accurately monitor these signals.

Cardiac pressure waveforms

Echocardiogram interpretation - LINK

James developed a system which is able to analyse video clips taking during echocardiogram scans, to identify which anatomical structures are present. His novel approached more than halved the error rate of previous solutions.

Echocardiogram view identification

T1 and T2 mapping

T1 and T2 mapping allows quantitative analysis of tissue characteristics on cardiac MRI scans so that doctors can better identify diseases. However, these measurements can be difficult and time consuming to make. James has developed a system to automated this process and it is now in use at two Hospitals.

T1 T2 mapping

Identification of successful His pacing - LINK

James worked with Dr Ahran Arnold to develop a system to identify a novel form of cardiac pacing has been delivered successfully using ECGs.

Other work

CoPhy - Coronary physiology in Python - LINK

CoPhy free to use coronary physiology package that can calculate the common coronary physiology parameters including FFR, iFR, DFR, RFR, CFR, BSR, BMR and HMR. Parameters are given for full cycle,
diastole, systole and the wave-free period. 

Cophy - The Cardiology Trials Database - LINK

James set up and runs the popular website, which serves as an independent, up to date summary of the key trials in clinical cardiology.


BARD ECG labelling system - LINK

An open source program to allow exporting of ECGs from the proprietary ‘BARD’ electrophysiology application. The program allows labelling of ECG waveforms to allow AI solutions to be trained on clinical ECG signals.

BARD software


Dr Howard has published extensively throughout cardiovascular medicine (h-index 24), but his interest in trial design and medical statistics means he is often asked to co-author meta-analyses alongside his usual research interests. James has been responsible for the analysis in the following papers.


- Drug eluting stents versus bypass grafting - Eur. Heart J.
- Patent foramen ovale closure - Eur. Heart J.
- Influence of bias in renal denervation trial, a meta-regression - Heart & Circ. Cardiovasc. Qual. Outcomes
- Atrial fibrillation ablation - JACC Clin. Electrophysiol.
- PCI in stable and unstable CAD - Circ. Cardiovasc. Qual. Outcomes
- Pacing for hypertrophic obstructive cardiomyopathy - Eur. Heart J. Qual. Care Clin. Outcomes
- Meta regression predictors of outcome in AF ablation trials - Europace & J. Cardiovasc. Electrophysiol.
- Complete revascularisation in STEMI - J. Am. Heart Assoc.
- Cerebral embolic protection - Am. J. Cardiol.
- Renal denervation - Cardiovasc. Revasc. Med.
- Single versus dual antiplatelets in TAVI - Cardiovasc. Revasc. Med. & Open Heart



Kanagaratnam P, Francis DP, Chamie D, et al., 2023, A randomised controlled trial to investigate the use of acute coronary syndrome therapy in patients hospitalised with COVID-19: the C19-ACS trial, Journal of Thrombosis and Haemostasis, ISSN:1538-7836

Kirtane AJ, Sharp ASP, Mahfoud F, et al., 2023, Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials., Jama Cardiol, Vol:8, Pages:464-473

Reddy R, Ahmad Y, Arnold A, et al., 2023, Cerebral embolic protection devices during transcatheter aortic valve implantation: a meta-analysis of randomized controlled trials, Journal of the Society for Cardiovascular Angiography & Interventions, ISSN:2772-9303

Warisawa T, Cook CM, Kawase Y, et al., 2023, Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry., Cardiovasc Interv Ther

Whinnett ZI, Shun-Shin MJ, Tanner M, et al., 2023, Effects of haemodynamically atrio-ventricular optimized His bundle pacing on heart failure symptoms and exercise capacity: the His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) randomized, double-blind, cross-over trial, European Journal of Heart Failure, Vol:25, ISSN:1388-9842, Pages:274-283

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