Imperial College London
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DrJamesHoward

Faculty of Medicine, National Heart & Lung Institute

Clinical Senior Lecturer in Cardiology (Cardiac MR and AI)
 
 
 
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james.howard1 Website CV

 
 
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Location

 

Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Foley:2022:10.1016/j.jscai.2022.100349,
author = {Foley, M and Hall, K and Howard, J and Ahmad, Y and Gandhi, M and Mahboobani, S and Okafor, J and Rahman, H and Hadjiloizou, N and Ruparelia, N and Mikhail, G and Malik, I and Kanaganayagam, G and Sutaria, N and Rana, B and Ariff, B and Barden, E and Anderson, J and Afoke, J and Petraco, R and Al-Lamee, R and Sen, S},
doi = {10.1016/j.jscai.2022.100349},
journal = {Journal of the Society for Cardiovascular Angiography & Interventions},
pages = {1--6},
title = {Aortic valve calcium score is associated with acute stroke in transcatheter aortic valve replacement patients},
url = {http://dx.doi.org/10.1016/j.jscai.2022.100349},
volume = {1},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundTranscatheter aortic valve replacement (TAVR) is the treatment of choice for patients with severe aortic stenosis who are at a moderate or higher surgical risk. Stroke is a recognised and serious complication of TAVR, and it is important to identify patients at higher stroke risk. This study aims to discover if aortic valve calcium score calculated from pre-TAVR computed tomography is associated with acute stroke in TAVR patients.MethodsWe conducted a retrospective, observational cohort study of 433 consecutive patients undergoing TAVR between January 2017 and December 2019 at the Hammersmith Hospital.ResultsThis cohort had a median age of 83 years (interquartile range, 78-87), and 52.7% were male. Fifty-two patients (12.0%) had a history of previous stroke or transient ischemic attack. Median aortic valve calcium score was 2145 (interquartile range, 1427-3247) Agatston units. Twenty-two patients had a stroke up to the time of discharge (5.1%). In a logistic regression model, aortic valve calcium score was significantly associated with acute stroke (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.01-1.53; P = .02). Acute stroke was also significantly associated with peripheral arterial disease (OR, 4.32; 95% CI, 1.65-10.65; P = .0018) and a longer procedure time (OR, 1.01; 95% CI, 1.00-1.02; P = .0006).ConclusionsAortic valve calcium score from pre-TAVR computed tomography is an independent risk factor for acute stroke in the TAVR population. This is an additional clinical value of the pre-TAVR aortic valve calcium score and should be considered when discussing periprocedural stroke risk.
AU  - Foley,M
AU  - Hall,K
AU  - Howard,J
AU  - Ahmad,Y
AU  - Gandhi,M
AU  - Mahboobani,S
AU  - Okafor,J
AU  - Rahman,H
AU  - Hadjiloizou,N
AU  - Ruparelia,N
AU  - Mikhail,G
AU  - Malik,I
AU  - Kanaganayagam,G
AU  - Sutaria,N
AU  - Rana,B
AU  - Ariff,B
AU  - Barden,E
AU  - Anderson,J
AU  - Afoke,J
AU  - Petraco,R
AU  - Al-Lamee,R
AU  - Sen,S
DO  - 10.1016/j.jscai.2022.100349
EP  - 6
PY  - 2022///
SN  - 2772-9303
SP  - 1
TI  - Aortic valve calcium score is associated with acute stroke in transcatheter aortic valve replacement patients
T2  - Journal of the Society for Cardiovascular Angiography & Interventions
UR  - http://dx.doi.org/10.1016/j.jscai.2022.100349
UR  - https://www.sciencedirect.com/science/article/pii/S2772930322003337
UR  - http://hdl.handle.net/10044/1/97091
VL  - 1
ER  -
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