Imperial College London
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ProfessorJamesMoore Jr

Faculty of Engineering, Department of Bioengineering

The Bagrit & RAEng Chair in Medical Device Design
 
 
 
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Contact

 

+44 (0)20 7594 9795james.moore.jr CV

 
 
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Location

 

414Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moore:2018:10.1146/annurev-fluid-122316-045259,
author = {Moore, JE and Bertram, CD},
doi = {10.1146/annurev-fluid-122316-045259},
journal = {Annu Rev Fluid Mech},
pages = {459--482},
title = {Lymphatic System Flows.},
url = {http://dx.doi.org/10.1146/annurev-fluid-122316-045259},
volume = {50},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The supply of oxygen and nutrients to tissues is performed by the blood system, and involves a net leakage of fluid outward at the capillary level. One of the principal functions of the lymphatic system is to gather this fluid and return it to the blood system to maintain overall fluid balance. Fluid in the interstitial spaces is often at subatmospheric pressure, and the return points into the venous system are at pressures of approximately 20 cmH2O. This adverse pressure difference is overcome by the active pumping of collecting lymphatic vessels, which feature closely spaced one-way valves and contractile muscle cells in their walls. Passive vessel squeezing causes further pumping. The dynamics of lymphatic pumping have been investigated experimentally and mathematically, revealing complex behaviours indicating that the system performance is robust against minor perturbations in pressure and flow. More serious disruptions can lead to incurable swelling of tissues called lymphœdema.
AU  - Moore,JE
AU  - Bertram,CD
DO  - 10.1146/annurev-fluid-122316-045259
EP  - 482
PY  - 2018///
SN  - 0066-4189
SP  - 459
TI  - Lymphatic System Flows.
T2  - Annu Rev Fluid Mech
UR  - http://dx.doi.org/10.1146/annurev-fluid-122316-045259
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29713107
VL  - 50
ER  -
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