Imperial College London
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ProfessorJamesMoore Jr

Faculty of Engineering, Department of Bioengineering

The Bagrit & RAEng Chair in Medical Device Design
 
 
 
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Contact

 

+44 (0)20 7594 9795james.moore.jr CV

 
 
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Location

 

414Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Moore:2018:10.1016/j.cobme.2018.03.001,
author = {Moore, Jr JE and Brook, B and Nibbs, RJB},
doi = {10.1016/j.cobme.2018.03.001},
journal = {Current Opinion in Biomedical Engineering},
pages = {90--95},
title = {Chemokine transport dynamics and emerging recognition of their role in immune function},
url = {http://dx.doi.org/10.1016/j.cobme.2018.03.001},
volume = {5},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood.  These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.
AU  - Moore,Jr JE
AU  - Brook,B
AU  - Nibbs,RJB
DO  - 10.1016/j.cobme.2018.03.001
EP  - 95
PY  - 2018///
SN  - 2468-4511
SP  - 90
TI  - Chemokine transport dynamics and emerging recognition of their role in immune function
T2  - Current Opinion in Biomedical Engineering
UR  - http://dx.doi.org/10.1016/j.cobme.2018.03.001
UR  - http://hdl.handle.net/10044/1/58041
VL  - 5
ER  -
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