Imperial College London

Professor James Seddon

Faculty of MedicineDepartment of Infectious Disease

Professor of Global Child Health



+44 (0)20 7594 3179james.seddon




235Norfolk PlaceSt Mary's Campus





I am a Professor of Global Child Health at Imperial, a Consultant in Paediatric Infectious Diseases at St. Mary's Hospital in London and an Associate Professor at Stellenbosch University. I divide my time between Cape Town and London. Clinical work includes the care of children with complex infectious diseases and my major area of research is that of children with tuberculosis.

I studied medicine at Corpus Christi College, Cambridge and Imperial College London and have carried out paediatric training in both the UK and Australia. Before clinical academia, I was an infantry officer in the British army, worked as a doctor for Médecins Sans Frontières in Côte d'Ivoire and spent time on an expedition in Patagonia. I undertook my PhD in Cape Town, studying drug-resistant tuberculosis in children, and have gained Diplomas in Tropical Medicine and Paediatric Infectious Diseases. During 2017 I spent six months at the Department of Global Health and Social Medicine in Harvard University on a Fulbright Scholarship evaluating different strategies to combat drug-resistant tuberculosis in children.

Between 2018 and 2022 I was funded through an MRC Clinician Scientist Fellowship to evaluate correlates of risk in children exposed to multidrug-resistant tuberculosis.

Selected Publications

Journal Articles

Gunasekera K, Seddon J, 2023, Development and validation of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis, The Lancet Child & Adolescent Health, Vol:7, ISSN:2352-4642, Pages:336-346

Ranasinghe L, Achar J, Groschel M, et al., 2022, The global impact of COVID-19 on childhood tuberculosis: analysis of notification data, The Lancet Global Health, Vol:10, ISSN:2214-109X, Pages:e1774-e1781

Turkova A, Wills GH, Wobudeya E, et al., 2022, Shorter treatment for non-severe tuberculosis in African and Indian children, New England Journal of Medicine, Vol:386, ISSN:0028-4793, Pages:911-922

Dodd P, Yuen C, Jayasooriya S, et al., 2021, Quantifying the global number of tuberculosis survivors: a modelling study, Lancet Infectious Diseases, Vol:21, ISSN:1473-3099, Pages:984-992

Yuen C, Seddon J, Keshavjee S, et al., 2020, Risk-benefit analysis of tuberculosis infection testing for household contact management in high-burden countries: a mathematical modelling study, The Lancet Global Health, Vol:8, ISSN:2214-109X, Pages:e672-e680

Snow KJ, Cruz AT, Seddon JA, et al., 2020, Adolescent tuberculosis, The Lancet Child & Adolescent Health, Vol:4, ISSN:2352-4642, Pages:68-79

Seddon J, Whittaker E, Kampmann B, et al., 2019, The evolving research agenda for paediatric tuberculosis infection, Lancet Infectious Diseases, Vol:19, ISSN:1473-3099, Pages:e323-e329

Dodd P, Yuen C, Becerra M, et al., 2018, The potential impact of household contact management on childhood tuberculosis: a mathematical modelling study, The Lancet Global Health, Vol:6, ISSN:2214-109X, Pages:e1329-e1338

Dodd P, Yuen C, Sismanidis C, et al., 2017, The global burden of tuberculosis mortality in children: amathematical modelling study, Lancet Global Health, Vol:5, ISSN:2214-109X, Pages:e898-e906

Dodd P, Sismanidis C, Seddon JA, 2016, The global burden of drug-resistant tuberculosis in children: a mathematical model, Lancet Infectious Diseases, Vol:16, ISSN:1473-3099, Pages:1193-1201

Dodd PJ, Gardiner E, Coghlan R, et al., 2014, Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study, The Lancet Global Health, Vol:2, ISSN:2214-109X, Pages:e453-e459

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