Publications
216 results found
Seddon JA, Garcia-Prats AJ, Kampmann B, et al., 2014, Toxicity and Tolerability of Fluoroquinolone-based Preventive Therapy for Childhood Contacts of Multidrug-resistant Tuberculosis, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 33, Pages: 1098-1099, ISSN: 0891-3668
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- Citations: 5
Turkova A, Seddon JA, Nunn AJ, et al., 2014, Short intensified treatment in children with drug-susceptible tuberculous meningitis, Pediatric Infectious Disease Journal, Vol: 33, Pages: 993-993, ISSN: 1532-0987
Franck C, Seddon JA, Hesseling AC, et al., 2014, Assessing the impact of multidrug-resistant tuberculosis in children: an exploratory qualitative study, BMC INFECTIOUS DISEASES, Vol: 14
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- Citations: 29
Dodd PJ, Gardiner E, Coghlan R, et al., 2014, Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study, The Lancet Global Health, Vol: 2, Pages: e453-e459, ISSN: 2214-109X
BackgroundConfirmation of a diagnosis of tuberculosis in children (aged <15 years) is challenging; under-reporting can result even when children do present to health services. Direct incidence estimates are unavailable, and WHO estimates build on paediatric notifications, with adjustment for incomplete surveillance by the same factor as adult notifications. We aimed to estimate the incidence of infection and disease in children, the prevalence of infection, and household exposure in the 22 countries with a high burden of the disease.MethodsWithin a mechanistic mathematical model, we combined estimates of adult tuberculosis prevalence in 2010, with aspects of the natural history of paediatric tuberculosis. In a household model, we estimated household exposure and infection. We accounted for the effects of age, BCG vaccination, and HIV infection. Additionally, we tested sensitivity to key structural assumptions by repeating all analyses without variation in BCG efficacy by latitude.FindingsThe median number of children estimated to be sharing a household with an individual with infectious tuberculosis in 2010 was 15 319 701 (IQR 13 766 297–17 061 821). In 2010, the median number of Mycobacterium tuberculosis infections in children was 7 591 759 (5 800 053–9 969 780), and 650 977 children (424 871–983 118) developed disease. Cumulative exposure meant that the median number of children with latent infection in 2010 was 53 234 854 (41 111 669–68 959 804). The model suggests that 35% (23–54) of paediatric cases of tuberculosis in the 15 countries reporting notifications by age in 2010 were detected. India is predicted to account for 27% (22–33) of the total burden of paediatric tuberculosis in the 22 countries. The predicted proportion of tuberculosis burden in children for each country correlated with incidence, varying between 4% and 21%.InterpretationOur model has shown that the incidence of paediatric tuberculosis is higher than
Schaaf HS, Hesseling AC, Rautenbach C, et al., 2014, Trends in childhood drug-resistant tuberculosis in South Africa: a window into the wider epidemic?, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 18, Pages: 770-773, ISSN: 1027-3719
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- Citations: 15
Seddon JA, Padayachee T, Du Plessis A-M, et al., 2014, Teaching chest X-ray reading for child tuberculosis suspects, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 18, Pages: 763-769, ISSN: 1027-3719
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- Citations: 17
Seddon JA, Shingadia D, 2014, Epidemiology and disease burden of tuberculosis in children: a global perspective, Infection and Drug Resistance, Vol: 7, Pages: 153-165, ISSN: 1178-6973
Tebruegge M, Ritz N, Koetz K, et al., 2014, Availability and Use of Molecular Microbiological and Immunological Tests for the Diagnosis of Tuberculosis in Europe, PLOS ONE, Vol: 9, ISSN: 1932-6203
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- Citations: 29
Schaaf HS, Garcia-Prats AJ, Hesseling AC, et al., 2014, Managing multidrug-resistant tuberculosis in children: review of recent developments, CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 27, Pages: 211-219, ISSN: 0951-7375
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- Citations: 23
Seddon JA, Hesseling AC, Godfrey-Faussett P, et al., 2014, High treatment success in children treated for multidrug-resistant tuberculosis: an observational cohort study, THORAX, Vol: 69, Pages: 471-477, ISSN: 0040-6376
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- Citations: 73
Zvada SP, Denti P, Donald PR, et al., 2014, Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: <i>in silico</i> evaluation of currently recommended doses, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 69, Pages: 1339-1349, ISSN: 0305-7453
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- Citations: 52
Seddon JA, Hesseling AC, Finlayson H, et al., 2013, Preventive Therapy for Child Contacts of Multidrug-Resistant Tuberculosis: A Prospective Cohort Study, CLINICAL INFECTIOUS DISEASES, Vol: 57, Pages: 1676-1684, ISSN: 1058-4838
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- Citations: 85
Rose PC, Schaaf HS, du Preez K, et al., 2013, Completeness and accuracy of electronic recording of paediatric drug-resistant tuberculosis in Cape Town, South Africa., Public Health Action, Vol: 3, Pages: 214-219, ISSN: 2220-8372
SETTING: Cape Town, South Africa. OBJECTIVE: To assess the completeness and accuracy of electronic recording of drug-resistant tuberculosis (DR-TB) in children. DESIGN: Retrospective cohort study. All children aged <15 years treated for DR-TB during 2012 were included, with clinical data collected from routine health services. Matching was performed between clinical data and an extracted data set from an electronic register for DR-TB (EDR.web), and data sources were compared. RESULTS: Seventy-seven children were identified clinically, of whom only 49 (64%) were found in EDR.web. Most data in EDR.web were complete and accurate, but there were some internal inconsistencies for confirmed TB. Only 4.4% of all EDR.web entries were children. CONCLUSION: Only two thirds of children clinically treated for DR-TB were recorded in the electronic reporting system, suggesting under-reporting. We also found a lower than expected prevalence of childhood DR-TB, probably suggesting both under-diagnosis and under-recording of DR-TB in children. Clinicians at facility level should be able to access the electronic reporting system, and data transfer between clinical paper-based and electronic sources should be simplified. Cross-linking between electronic registers for drug-susceptible and DR-TB or consolidation of registers could improve the accuracy of recording. Improved recording and reporting of DR-TB in children is needed.
Seddon JA, Hesseling AC, Godfrey-Faussett P, et al., 2013, Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis: a cross-sectional study, BMC Infectious Diseases, Vol: 13, ISSN: 1471-2334
Seddon JA, Perez-Velez CM, Schaaf HS, et al., 2013, Consensus statement on research definitions for drug-resistant tuberculosis in children, Journal of the Pediatric Infectious Diseases Society, Vol: 2, Pages: 100-109, ISSN: 2048-7207
Seddon JA, Thee S, Jacobs K, et al., 2013, Hearing loss in children treated for multidrug-resistant tuberculosis, JOURNAL OF INFECTION, Vol: 66, Pages: 320-329, ISSN: 0163-4453
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- Citations: 67
Seddon JA, Hesseling AC, Schaaf HS, 2013, Retooling Existing Tuberculosis Drugs for Children, CLINICAL INFECTIOUS DISEASES, Vol: 56, Pages: 167-U210, ISSN: 1058-4838
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- Citations: 3
Rose PC, Hallbauer UM, Seddon JA, et al., 2012, Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 16, Pages: 1588-1593, ISSN: 1027-3719
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- Citations: 37
Seddon JA, Furin JJ, Gale M, et al., 2012, Caring for Children with Drug-Resistant Tuberculosis Practice-based Recommendations, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 953-964, ISSN: 1073-449X
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- Citations: 54
Schaaf HS, Seddon JA, 2012, Epidemiology and management of childhood multidrug-resistant tuberculosis, Clinical Practice, Vol: 9, Pages: 701-713, ISSN: 2044-9038
Multidrug-resistant tuberculosis (TB) in children is mainly caused by transmission of drug-resistant strains causing infection and disease (i.e., primary drug-resistant TB) and, therefore, follows adult multidrug-resistant TB trends. Diagnosis is made by culture and phenotypic or genotypic drug susceptibility testing, either from the child's or the adult source case's Mycobacterium tuberculosis isolate. Treatment is mainly with second-line anti-TB drugs, building a regimen with four effective drugs; the principles of management are the same as for adults. Monitoring for adverse events is important as second-line drugs are more toxic than first-line treatment. With early diagnosis and treatment, outcome is better than in adults. New drugs and drug combinations are in development and should also be evaluated in children. © 2012 Future Medicine Ltd.
Seddon JA, Godfrey-Faussett P, Jacobs K, et al., 2012, Hearing loss in patients on treatment for drug-resistant tuberculosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 40, Pages: 1277-1286, ISSN: 0903-1936
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- Citations: 71
Seddon JA, Donald PR, Vlok GJ, et al., 2012, Multidrug-Resistant Tuberculosis of the Spine in Children-Characteristics from a High Burden Setting, JOURNAL OF TROPICAL PEDIATRICS, Vol: 58, Pages: 341-347, ISSN: 0142-6338
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- Citations: 10
Seddon JA, Hesseling AC, Dunbar R, et al., 2012, Decentralised care for the management of child contacts of multidrug-resistant tuberculosis, Public Health Action, Vol: 2, Pages: 66-70, ISSN: 2220-8372
Zimri K, Hesseling AC, Godfrey-Faussett P, et al., 2012, Why do child contacts of multidrug-resistant tuberculosis not come to the assessment clinic?, Public Health Action, Vol: 2, Pages: 71-75, ISSN: 2220-8372
Seddon JA, Warren RM, Enarson DA, et al., 2012, Drug-resistant tuberculosis transmission and resistance amplification within families, Emerging Infectious Diseases, Vol: 18, Pages: 1342-1345, ISSN: 1080-6059
Seddon JA, Hesseling AC, Marais BJ, et al., 2012, The evolving epidemic of drug-resistant tuberculosis among children in Cape Town, South Africa, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 16, Pages: 928-933, ISSN: 1027-3719
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- Citations: 46
Seddon JA, Visser DH, Bartens M, et al., 2012, Impact of Drug Resistance on Clinical Outcome in Children With Tuberculous Meningitis, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 31, Pages: 711-716, ISSN: 0891-3668
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- Citations: 34
Seddon JA, Jordaan AM, Victor TC, et al., 2012, DISCORDANT DRUG SUSCEPTIBILITY FOR <i>MYCOBACTERIUM TUBERCULOSIS</i> WITHIN FAMILIES, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 31, Pages: 783-785, ISSN: 0891-3668
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- Citations: 3
Seddon JA, Godfrey-Faussett P, Hesseling AC, et al., 2012, Management of children exposed to multidrug-resistant <i>Mycobacterium tuberculosis</i>, LANCET INFECTIOUS DISEASES, Vol: 12, Pages: 469-479, ISSN: 1473-3099
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- Citations: 52
Ettehad D, Schaaf HS, Seddon J, et al., 2012, Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis, Lancet Infectious Diseases
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