Imperial College London
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Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3179james.seddon

 
 
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Location

 

235Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{McArdle:2020:10.5588/ijtld.19.0626,
author = {McArdle, A and Keane, D and Seddon, J and Bernatoniene, J and Paton, J and McMaster, P and Williams, A and Williams, B and Kampmann, B},
doi = {10.5588/ijtld.19.0626},
journal = {International Journal of Tuberculosis and Lung Disease},
pages = {782--788},
title = {Vitamin D deficiency is associated with tuberculosis disease in British children},
url = {http://dx.doi.org/10.5588/ijtld.19.0626},
volume = {24},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background53Basic science, epidemiological and interventional research supports a link between vitamin D and 54tuberculosis immunity, infection and disease. We evaluated the association between vitamin D 55levels and tuberculosis (TB) infection and disease in UK children recruited to the NIHR IGRA Kids 56Study (NIKS).57Methods58Children presenting between 2011-2014 were eligible if they had history of exposure to an adult 59case with sputum smear/culture-positive TB, or were referred and diagnosed with TB disease. 60Children were assessed at baseline and 6-8 weeks for immunological evidence of TB infection (IGRA 61and/or tuberculin skin test) and evidence of TB disease. Some centres routinely measured total 25-62hydroxy vitamin D levels.63Results64166 children were included. Median 25-hydroxy vitamin D levels were higher in uninfected children 65(45.5 nmol/l) compared to those with infection (36.2 nmol/l) and disease (20.0 nmol/l). The 66difference between TB infection and disease was statistically significant (p<0.001). By logistic 67regression, lower vitamin D levels were associated with TB disease among participants with 68infection/disease, with no evidence of confounding by age, sex, BCG status, ethnicity, non-contact 69referral, season or centre.70Conclusion71Children with TB disease had lower vitamin D levels than children with infection. Implications for 72prevention and treatment remain to be established.
AU  - McArdle,A
AU  - Keane,D
AU  - Seddon,J
AU  - Bernatoniene,J
AU  - Paton,J
AU  - McMaster,P
AU  - Williams,A
AU  - Williams,B
AU  - Kampmann,B
DO  - 10.5588/ijtld.19.0626
EP  - 788
PY  - 2020///
SN  - 1027-3719
SP  - 782
TI  - Vitamin D deficiency is associated with tuberculosis disease in British children
T2  - International Journal of Tuberculosis and Lung Disease
UR  - http://dx.doi.org/10.5588/ijtld.19.0626
UR  - http://hdl.handle.net/10044/1/76598
VL  - 24
ER  -
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