Imperial College London
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Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3179james.seddon

 
 
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Location

 

235Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{van:2020:10.1186/s12879-020-05653-9,
author = {van, der Zalm M and Walters, E and Classsen, M and Palmer, M and Seddon, J and Demers, AM and Shaw, ML and McCollum, ED and van, Zyl GU and Hesseling, AC},
doi = {10.1186/s12879-020-05653-9},
journal = {BMC Infectious Diseases},
title = {High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis},
url = {http://dx.doi.org/10.1186/s12879-020-05653-9},
volume = {20},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe presentation of pulmonary tuberculosis (PTB) in young children is often clinically indistinguishable from other common respiratory illnesses, which are frequently infections of viral aetiology. As little is known about the role of viruses in children with PTB, we investigated the prevalence of respiratory viruses in children with suspected PTB at presentation and follow-up.MethodsIn an observational cohort study, children < 13 years were routinely investigated for suspected PTB in Cape Town, South Africa between December 2015 and September 2017 and followed up for 24 weeks. Nasopharyngeal aspirates (NPAs) were tested for respiratory viruses using multiplex PCR at enrolment, week 4 and 8.ResultsSeventy-three children were enrolled [median age 22.0 months; (interquartile range 10.0–48.0); 56.2% male and 17.8% HIV-infected. Anti-tuberculosis treatment was initiated in 54.8%; of these 50.0% had bacteriologically confirmed TB. At enrolment, ≥1 virus were detected in 95.9% (70/73) children; most commonly human rhinovirus (HRV) (74.0%). HRV was more frequently detected in TB cases (85%) compared to ill controls (60.6%) (p = 0.02). Multiple viruses were detected in 71.2% of all children; 80% of TB cases and 60.6% of ill controls (p = 0.07). At follow-up, ≥1 respiratory virus was detected in 92.2% (47/51) at week 4, and 94.2% (49/52) at week 8.ConclusionsWe found a high prevalence of viral respiratory co-infections in children investigated for PTB, irrespective of final PTB diagnosis, which remained high during follow up. Future work should include investigating the whole respiratory ecosystem in combination with pathogen- specific immune responses.
AU  - van,der Zalm M
AU  - Walters,E
AU  - Classsen,M
AU  - Palmer,M
AU  - Seddon,J
AU  - Demers,AM
AU  - Shaw,ML
AU  - McCollum,ED
AU  - van,Zyl GU
AU  - Hesseling,AC
DO  - 10.1186/s12879-020-05653-9
PY  - 2020///
SN  - 1471-2334
TI  - High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis
T2  - BMC Infectious Diseases
UR  - http://dx.doi.org/10.1186/s12879-020-05653-9
UR  - http://hdl.handle.net/10044/1/85005
VL  - 20
ER  -
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