Imperial College London
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Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3179james.seddon

 
 
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Location

 

235Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{du:2022:10.3389/fneur.2022.751133,
author = {du, Preez K and Jenkins, H and Donald, P and Solomons, R and Graham, S and Schaaf, S and Starke, J and Hesseling, A and Seddon, J},
doi = {10.3389/fneur.2022.751133},
journal = {Frontiers in Neurology},
pages = {1--9},
title = {Tuberculous meningitis in children: a forgotten public health emergency},
url = {http://dx.doi.org/10.3389/fneur.2022.751133},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculous meningitis (TBM) remains a major cause of morbidity and mortality in children with tuberculosis (TB), yet there arecurrently no estimates of the global burden of paediatric TBM. Due to frequent non-specific clinical presentation and limited andinadequate diagnostic tests, children with TBM are often diagnosed late or die undiagnosed. Even when diagnosed and treated, 20%of children with TBM die. Of survivors, the majority have substantial neurological disability with significant negative impact onchildren and their families. Surveillance data on this devastating form of TB can help to quantify the contribution of TBM to theoverall burden, morbidity and mortality of TB in children and the epidemiology of TB more broadly.Paediatric TBM usually occurs shortly after primary infection with Mycobacterium tuberculosis and reflects ongoing TBtransmission to children. In this article we explain the public health importance of paediatric TBM, discuss the epidemiology withinthe context of overall TB control and health system functioning and the limitations of current surveillance strategies. We provide aclear rationale for the benefit of improved surveillance of paediatric TBM using a TB care cascade framework to supportmonitoring and evaluation of paediatric TB, and TB control more broadly. Considering the public health implications of a diagnosisof TBM in children, we provide recommendations to strengthen paediatric TBM surveillance and outline how improved surveillancecan help us identify opportunities for prevention, earlier diagnosis and improved care to minimize the impact of TBM on childrenglobally.
AU  - du,Preez K
AU  - Jenkins,H
AU  - Donald,P
AU  - Solomons,R
AU  - Graham,S
AU  - Schaaf,S
AU  - Starke,J
AU  - Hesseling,A
AU  - Seddon,J
DO  - 10.3389/fneur.2022.751133
EP  - 9
PY  - 2022///
SN  - 1664-2295
SP  - 1
TI  - Tuberculous meningitis in children: a forgotten public health emergency
T2  - Frontiers in Neurology
UR  - http://dx.doi.org/10.3389/fneur.2022.751133
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2022.751133/full
UR  - http://hdl.handle.net/10044/1/95129
VL  - 13
ER  -
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