Imperial College London
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Professor James Seddon

Faculty of Medicine, Department of Infectious Disease

Professor of Global Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3179james.seddon

 
 
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Location

 

235Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wademan:2022:10.1371/journal.pone.0268560,
author = {Wademan, D and Goddinott, G and Purchase, S and Seddon, J and Hesseling, A and Garcia-Prats, A and Reis, R and Reynolds, L},
doi = {10.1371/journal.pone.0268560},
journal = {PLoS One},
pages = {1--18},
title = {Practical and psychosocial challenges faced by caregivers influence the acceptability of multidrug-resistant tuberculosis preventive therapy for young children},
url = {http://dx.doi.org/10.1371/journal.pone.0268560},
volume = {17},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Drug-resistant (DR) strains of Mycobacterium tuberculosis (M. tb) are increasingly recognised as a threat to global tuberculosis (TB) control efforts. Identifying people with DR-TB exposure/ infection and providing TB preventive therapy (TPT) is a public health priority. TB guidelines advise the evaluation of household contacts of newly diagnosed TB cases, with the provision of TPT to vulnerable populations, including young children (<5 years). Many children become infected with TB through exposure in their household. Levofloxacin is under evaluation as TPT in children exposed to M. tb strains with resistance to rifampicin and isoniazid (multidrug-resistant TB; MDR-TB).Prior to opening a phase 3 prevention trial in children <5 years exposed to MDR-TB, the pharmacokinetics and safety of a novel formulation of levofloxacin given daily was evaluated as part of a lead-in study. We conducted an exploratory qualitative study of 10 caregivers’ experiences of administering this formulation. We explored how the acceptability of levofloxacin as TPT is shaped by the broader impacts of MDR-TB on the overall psychological, social, and financial wellbeing of caregivers, many of whom also had experienced MDR-TB.Caregivers reported that the novel levofloxacin formulation was acceptable. However, caregivers described significant psychosocial challenges in the process of incorporating TPT administration to their children into their daily lives, including financial instability, withdrawal of social support and stigma. When caregivers themselves were sick, these challenges became even more acute. Although new child-friendly formulations can ameliorate some of the pragmatic challenges related to TPT preparation and administration, the overall psychosocial burden on caregivers responsible for administering TPT remains a major determinant of effective MDR-TB prevention in children.
AU  - Wademan,D
AU  - Goddinott,G
AU  - Purchase,S
AU  - Seddon,J
AU  - Hesseling,A
AU  - Garcia-Prats,A
AU  - Reis,R
AU  - Reynolds,L
DO  - 10.1371/journal.pone.0268560
EP  - 18
PY  - 2022///
SN  - 1932-6203
SP  - 1
TI  - Practical and psychosocial challenges faced by caregivers influence the acceptability of multidrug-resistant tuberculosis preventive therapy for young children
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0268560
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268560
UR  - http://hdl.handle.net/10044/1/97831
VL  - 17
ER  -
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